Hygienic assessment of chemicals' level in food products and health risk assessment of the population in Arkhangelsk region were carried out. Levels of heavy metal contamination of certain food groups do not exceed allowable hygienic standards. Non-cancer risk was high for a hormonal system (HI = 3,9), nervous (HI = 3,4) and immune (HI = 3,2) systems, skin (HI = 3,2). The priority pollutants of food products were arsenic and lead. Total cancer risk was high (CR = 1,4 х 10^-3) and could be associated with fish contamination by inorganic arsenic (44,0 %).

It was established that 77,72 ± 1,38 % of students have normal nutritional status, 13,50 ± 2,57 % -inadequate nutritional status, and of 8,78 ± 2,70 % - redundant power status. A significant part of the diets account for bakery and confectionery products, at the same time revealed a low consumption of such basic foods as milk and dairy products, meat, fish. The energy value of the diets of the students were below the physiological norms by reducing the income of protein and carbohydrates. Students are also experiencing a shortage of virtually all vitamins and most minerals. It was established that the quality of life of students with different nutritional status differs, girls have reduced quality of life when excess nutritional status, in boys - while insufficient.

Vitamin deficiency among children in Russia is urgently issue. Chemical substances of technogenic origin are considered as a significant factor affecting the level of vitamin provision for children. The study aimed to analyze vitamin A, C, D, B₆ and B₁₂ level in the blood of 188 children aged 6 years attending pre-school educational institution located in the territory of a large industrial centre with determined concentration content of organic substances of technogenic origin (phenol, formaldehyde, ethylbenzene and chlorinated organic compounds) exceeding the hygienic standards in the ambient air, the air in pre-school educational institution and drinking water. Child diet was assessed. Besides, sampling and assessment of the quality of atmospheric air, indoor air and drinking water in pre-school educational institution were carried out. It was found that more than 75 % of children have a reduced level of vitamins in the blood, even under the provision of nutrition with vitamins at the level of physiological requirements and diet balance. The relation between the decrease in the vitamin level provision for children and high level of organic compounds in the blood of the children examined was revealed. A long-term intake of organic compounds with air and water leads to disorders of the antioxidant system, as evidenced by the decrease in the level of antioxidant enzymes (succinate dehydrogenase and glutathione peroxidase) and the level of total antioxidant activity of blood serum among children examined. Under chronic entering of chemical substances of technogenic origin and decrease in functional activity of the oxidative-antioxidant system enzyme link, the role of non-enzymatic reactions of antioxidant protection supported by vitamins increases that leads to their increased consumption. The vitamin deficiency is caused by their increased consumption under chronic toxicant load that requires a new approach when developing a set of measures aimed at preventing hypovitaminosis in children living under sanitary and hygienic disadvantage caused by the organic compound complex of technogenic origin in environmental objects.

The leading unfavorable factors of the educational environment and the educational process that contributed to the development of myopia in students were the irrational distribution of the educational load in accordance with the difficulty of subjects and the dynamics of student performance, the pronounced intensity of the learning process due to sensory loads as a result of the considerable stress of the visual analyzer in classrooms, against background insufficient artificial lighting and unfavorable air-thermal conditions in classrooms. Every third student has a visual impairment, with the leading pathology being middle degree myopia, which by the end of the 10th grade increased by 2.7 times.

The article presents the results of assessing the functional status of female students participating in the implementation of the standards of the GTO complex (Ready for Labor and Defense complex). Morphofunctional indices, hemodynamic features and parameters of the vascular bed were analyzed. Differences in the adaptability of students participating in the implementation of the standards of GTO complex have been established.

Indicators of systemic hemodynamics were evaluated. Those were blood pressure (BP), shock volume of the blood (SVB), peripheral vascular resistance (PVR), cardiac index (CI) and others. They were evaluated in 41 students. Their age was between 21 and 26 years. It was determined that the majority of central hemodynamics indicators importantly depend on the character of differences of actual frequency of heart rates and their meanings. The most important indicators of hemodynamics such as shock volume of the blood and heart index were lower and diastolic arterial blood pressure and peripheral vascular resistance were higher in people with heart rates higher than required normal heart rates. Important peculiarities of correlative interconnections between parameters of central hemodynemics depending on heart rates were revealed. The above peculiarities of hemodynemics depending on the character of differences of actual and normal heart rates confirm the importance of evaluation and understanding of such a simple parameter.

The purpose of the work was to justify the system of preventive measures to ensure hygienic and epidemiological safety of the population in the context of the impact of natural and technogenic factors in the Don water basin. The objects were the Don River, its tributaries, sources of drinking water supply. The water quality was assessed by hygienic and epidemiological safety indicators. The peculiarities of the formation of water quality in the Don River under the influence of technogenically altered tributaries within the industrialized city are revealed, which consist in reliable deterioration of sanitary, chemical and microbiological indicators. The monitoring system has been improved. On the basis of an assessment of the degree of sanitary and epidemiological reliability of water supply to the population, priority factors and indicators that significantly affect the quality of drinking water supplied to the consumer are identified. Based on the results of the research, a scientific substantiation of a set of measures for reducing the technogenic load on the Don River and ensuring the normative quality of drinking water was carried out.

The unfavorable sanitary-epidemiological situation in the conditions of natural disasters and man-made disasters testifies to the need to improve the activities of the sanitary-epidemiological service as one of the most important links in ensuring the safety of the environment for public health. In an emergency situation related to the unfavorable flood situation in the Tuapse district of Krasnodar region in 2012 and 2014, an increase in the incidence of the sum of acute intestinal infections (AH) in the post-flood periods was registered, which exceeded the average long-term morbidity rate by 33.3 % and 20.9 °%, respectively. Mostly recorded All bacterial etiology to 53.8 %, caused by conditionally pathogenic microflora. The peculiarity of the situation was an increase in the population of intestinal infections of viral etiology by 20 times and caused by pathogenic microorganisms by 2 times compared to the preplant period. The share of water factor in the transmission of All cases was 34.8 % in 2012, 14.7 % in 2014, the leading pathway of infection - contact and household. The implementation of sanitary-hygienic and anti-epidemic measures provided the operational management of the system of life support of the population during the natural disaster.

The article presents the materials on the study of stability of the major quality parameters of five experimental series of standard sample of magnosorbent from Stavropol Antiplague Institute of Rospotrebnadzor (registration No. 007-9388-2015). Persistence of stability of the magnosorbent standard sample parameters has been confirmed, without changes in appearance and without loss of absorption intensity through the whole period of observations. Applying a standard sample of magnosorbent as a magnetic matrix will allow to optimize the production process obtaining precise and comparable results, considerably improving the biological parameters of newly-developed or already produced magnoimmunosorbent products for diagnostics. The results of the performed study of stability of the assessed parameters in the process of storage allow to recommend a 3-year warranty shelf life of the magnosorbent standard sample.

The objective of research was to study the genotypes of noroviruses, that caused outbreaks and sporadic incidence of norovirus infection in the Khabarovsk region in 2015-2018. The analysis of outbreaks due to norovirus infection in the Khabarovsk Region in 2015-2018 was performed. The molecular genetic study of samples from 60 patients from three norovirus outbreaks in the Khabarovsk Region and from 164 children with sporadic acute gastroenteritis in Khabarovsk region was performed. Genotype of noroviruses was determined by sequencing method, phylogenetic analysis of the obtained nucleotide sequences was carried out. The norovirus genotypes GII.17, GII.4 Sydney_2012 and GII.6 had caused the outbreaks of norovirus infection in the Khabarovsk region in 2015-2018. Sporadic cases of acute gastroenteritis in children in Khabarovsk in 2016 were due to GII.4 Sydney_2012, GII.3 and GII.6 norovirus genotypes. Detection of the GII.4 Sydney_2012 strain in both outbreaks and sporadic norovirus infection cases in the Khabarovsk region in 2016 evidenced of active circulation of this variant type during this period. The genotype GII.6 had been identified in Khabarovsk from 2016 to 2018.

Bronchial asthma, which is a problem all around the world, has relevance also in Russia and in the Republic of Mordovia in particular. In the Republic reveals a growing number of cases of this disease. The incidence of asthma is more pronounced in areas with higher levels of air pollution.

The article considers problematic practical moments of compliance with the rules and methods of research of safety indicators of non-food products in accordance with the requirements of the Technical Regulations of the Customs Union. The authors give examples of the inconsistency of the measurement procedures presented in the lists, indicated in the lists of various technical regulations for the study of non-food products, directly affects the work of laboratories and limits their ability to conduct research. Using the example of methods for determining the concentration of formaldehyde in air extracts indicated in different technical regulations for non-food products, it is shown that in practice there are situations when the same safety index for different groups of goods is investigated according to different measurement methods. It has been shown that until now in the lists of documents in the field of standardization, containing rules and methods of research (testing) and measurements, there are methods that do not meet the sensitivity requirements specified in the same technical regulations, as well as certain documents that have become invalid. Proposals on synchronization of rules and methods for researching the safety indicators of non-food products for timely provision of sanitary and epidemiological surveillance with objective data on valid up-to-date documents have been developed.

To assess the informative value of the expansion of the laboratory tests complex in conducting biological monitoring of lead exposure to the organism, in workers of a lead recycling plant there were determined iron and ferritin levels for the analysis of the association of iron metabolism disorders with chronic exposure to lead, polymorphisms of the hemochromatosis gene as a risk factor for increased lead absorption, erythrocytes and reticulocytes parameters for the detection of early signs of toxic effects of lead on erythropoiesis. There was determined an importance of an estimation of an iron metabolism in workers exposed to lead for detecting risk groups of conditions connected with an iron overload. To assess the early signs of the toxic effect of lead on erythropoiesis, it is informative not only to determine the amount of reticulocytes, but also to estimate the ratio of reticulocyte fractions. The determination of the polymorphism of the hemochromatosis gene can be used to assess the individual risk of developing lead poisoning.