The article points out the importance of methodical approaches development for laboratory support of mass international events from the standpoint of hygienic safety of.

The research subject is chronic hepatites B and C incidence amongst the Samara region population. We discussed the related social aspects of these infections in the article. The research was carried out on the basis of statistical data on infectious diseases statistical data for 2000-2014, provided by the Department of The Federal Service for Supervision of Consumer Rights Protection and Human Well-Being (Rospotrebnadzor) of Samara region. The data for 2015-2017 have been analyzed from annually published State Reports «The state of sanitary and epidemiological welfare of the population in Samara region». During the research, we analyzed the epidemic situation of the diseases and outlined comparative description about the Samara region and Russian Federations incidence rates. We analyzed the ratio of urban and rural population incidence rates and described the age structure of the population incidence in the region. We analyzed the morbidity in three main population groups: younger than working age, working age and older than working age. Comparative analysis of the morbidity was carried out the subjects of Samara region with a high and low level of socio-economic well-being. We gave the degree evaluation of socioeconomic damage from chronic hepatitis B and C and reflected the social significance of these diseases for society. We also offer the ways for problem solution and optimization of the health authorities costs aimed to the decreasing of hepatites incidence.

The article presents the results analysis of preventive medical examination for adults in the Shpakovsky region of Stavropol region for 2015-2017. In the disease structure cardiovascular diseases ranks first, endocrine disorders has the second highest rate of incidence, genitourinary system diseases ranked third. The main risk factor for the chronic non-communicable diseases is unbalanced diet (35,74 °%). Low physical activity ranks second accroding to the results of questionnaire (31,23 %) and high blood pressure ranked third (24,45 %). Frequency rate of chronic non-comminicable risk factors detection had been decreased during the years.

The basic tendencies in development of modern education are defined. In the article we defined the main trends of modern education development and outlined the main problems of technotronic education. We presented the scientific data of information technologies impact on children and defined the potential IT-related risks for children health and development. The following solution for the problems related to education digitalization have been suggested.

The article presents the results of rate hygienic assessment for sambo-practicing athletes, and shows the expediency of amateur combative sport involving students of higher educational institutions as an alternative or an elective course to traditional approaches is showny. During the research, 2 experienced groups were formed from among the students of Barnaul at the age of 19-21 years, engaged in sambo on an amateur level for 2-3 years, engaged mainly in anaerobic load, aimed at increasing muscle mass and as a control group, students, not engaged in any kind of sport, while related to the main group of health. As a result, it was found that physical performance and physical fitness indicators in most cases are statistically significantly higher in the experimental groups, compared to students who do not engage in any kind of sport, while belonging to the main group of health in relation to physical training, somatometric and somatoscopic the indices determined in the two control and experimental groups showed that students of sambo-wrestlers do not have pathology of the arch of the foot. Physiometric parameters reflecting the functioning of the cardiovascular and respiratory systems of the organism showed great training of the systems in the representatives of the first control group, which was reflected in the optimal values of arterial pressure and statistically significantly greater vital capacity of the lungs, which is due to prolonged aerobic and intermittent physical exertion. Thus, it seems promising to introduce the training process of fighting sambo in the physical activity of student youth.

We carried out the nutrition ration hygienic assessment in two groups of students who are getting an education to become drillers in an oil-gas exploration college. The first group involved students aged 1517, 2nd group - students aged 18-20. The diet for students from both groups is intake in below of principles quantitative and qualitative characteristics of balanced diet. The diet of 15-17 years old students (1st group) is described below by the following indicators: fat content is reduced by 40,6 % rate, potassium - by 45,9 %, iodine - by 47,9 %, phosphorus - by 10,1 %, and iron content raised by 35,3% from the physiological norm; in the diet of the 2nd group reduction of fat content by 20,8 %, iodine by 54,9 %, calcium by 35,1 % and overlimited concentration of proteins by 49,3 %, carbohydrates by 28,9 %, iron by 102,9 %, phosphorus by 102,5 % was also found.

The influence of speed and temperature of the air was evaluated in various combinations in Dagestan. At height of 4m above sea level, the risk of hyperthermia became plausible during 7, the risk of hypothermia became plausible with combinations of minimum temperature with average (January) and maximum wind - 5 months. In the period from October to March, there was a moderate or critical risk of frostbite. At the height of 1 661 m, the risk of hyperthermia became significant during 3-6 months, the risk of hypothermia was possible during 3-7 months; during winter period with the combinations of minimum temperature and maximum wind, the risk of freezing injury was critical.

In experimental conditions, an assessment was given on the efficiency of active chlorine effect on the viability of microorganisms having a sanitary-epidemiological significance. It was shown that in conditions of intensive water source contamination of maximum load using treatment facilities with double chlorination (chlorine dose 5 mg/l) after 30 minutes of contact, only E.coli died, at the same time, conditionally pathogenic and pathogenic microorganisms, the infective dose of which was within the same limits (50 000 CFU/l), were inactivated by 99,9 %; with an increase in the applied dose of 10 and 100 times, the degree of inactivation decreased in Salmonella to 99,5 %, in Pseudomonas aeruginosa to 99,2 %, Klebsiella remained at the same level of 99,9 %. This predetermines the possibility of their appearance in drinking water, which can lead to the emergence of acute intestinal infections among the population.

The aim of the study was to analyze the expression of V. cholerae genes that are part of the VcB island by means of full-genomic sequencing of the transcriptome. The VcB island is localized on the second chromosome in all toxigenic vibrios studied and is absent in the atoxigenic apiliated strains. Two strains of V. cholerae O1 ctxA+ tcpA+ and one strain V. cholerae O1 ctxA- tcpA- were studied. The pool of total RNA vibrios was isolated by a technique based on differential precipitation in the presence of lithium ions. In the total pool of sequenced RNA, RNA encoded in the order of 3 500 by known cholera vibrio genes was identified. In a pool of total RNA from two ctx + tcpA + strains RNA transcripts were found for the five genes included in the VcB island, excluding the VCA0282 gene, previously identified as the ISVch5-transposase. In the the pool of total RNA from the ctx- tcpA- strain no transcripts of the two genes previously described as VCA0282-transposase and VCA0283 were detected. A possible explanation may be the existence of copies of these genes in other parts of the genome of the ctxA- tcpA-V. cholerae.

The results of the study of the acoustic safety of professional activities of the maneuverable aviation flight crew showed that the noise working conditions corresponded to the «harmful» class, and the infrasound to the «acceptable» class. At the same time, the majority of acoustic conditions in maneuverable aircraft cockpits are in close proximity to the maximum permissible levels, which necessitates the implementation of a hygienic monitoring system for the working conditions of the flying maneuver aircraft with an acoustic factor and the carrying out of preventive measures.

In this article the issue with transition from the Russian system of labor protection of absolute safety to a professional risk assessment is discussed. The main directions of improvement of legal mechanisms of providing a priority of prevention of risks of violations of health of workers in the course of work on the near-term outlook are presented.

In this article an analysis of the changing manifestations of the epidemic process of infectious mononucleosis (IM) for the period 2000-2016 is presented. In the course of retrospective epidemiological analysis the territorial heterogeneity of the manifestations of the epidemic process with a growth trend of the incidence rate across all subjects of the Russian Federation is established. The epidemic threshold has been exceeded by 49.4 % of the country's territory. It is noted that in the structure of infections with an aspiration mechanism of transmission since 2010 was ranked number 2 (excluding respiratory tract infections with an incidence of more than 100,0 100 thousand of us.). The conducted research allows to state that in the territory of Russia the difficult epidemic situation was formed infectious mononucleosis.

During the research we identified the MLVA-types of Vibrio cholerae O1 and Vibrio cholerae non O1/O139 strains that were isolated during environmental monitoring and patients with acute intestinal infections (AII) at various territories of the Caucasus and Trancaucasian region. Analysis of the dendrograms based on the MLVA-typing of 25 non-toxigenic Vibrio choleraе O1 and Vibrio cholerae non O1/O139 strains on 4 loci isolated from environmental samples and 3 toxigenic of V. cholerae isolated from humans on 5 loci has revealed various degree of phylogenetic relations strains isolated within various territories in different taking into account during the cholera agents monitoring in environmental samples at a certain territory.