The article describes the stages of formation and publication of the journal «Population Health and Life Environment - PH&LE».

The article reflects the principal objectives and activities of the journal «Population Health and Life Environment - PH&LE» at the present time. An analysis of main issues highlighted in it has been conducted. A characteristic has been given to the journal in light of basic requirements to peer-reviewed scientific publications.

This work describes the development of the analytical methodology for determining fipronil and metabolite of a fipronil-sulfone residues in eggs, products egg dry food (eggs power), meat, offal of a poultry by gas chromatography with two detecting systems: electron-capture detection (GC-ECD) and mass spectrometry (GC-MS). Two approaches of sample preparation are presented: it agrees to the first -substances extract mix acetone acetonitrile, clear an aliquot of extract the adsorptive chromatography on silica gel and the florisil. The second approach includes extraction of analytes the acetonitrile containing 1% of acetic acid in the presence of MgSO4 and NaCl, cleaning with dispersive solid-phase extraction with use of mix of sorbents (C18, PSA, GCB). LOQ: 0,002-0,005 mg/kg, recovery - 82-104 %, RSD repeatability - 5,9-13,0 %.

On the basis of mathematical modeling of links in the system "environment - human health - control and supervisory actions of Rospotrebnadzor", were obtained data on reliable dependences of mortality and morbidity rates of the population in Russian regions on the frequency of violations of hygienic standards for the content of harmful chemical and biological substances in the air, drinking water and soils of urban and rural settlements. It is shown that in Russia in 2017 harmful influence of environment factors is probabilistically associated with almost 64.9 thousand deaths and more than 5.1 million cases of diseases of children and adults. Rospotrebnadzor prevented about 48.1 thousand deaths and more than 7 million cases of infectious diseases, respiratory diseases, digestion, tumors, skin and subcutaneous tissue diseases, etc., associated mainly with unsatisfactory quality of drinking water and atmospheric air. Over 43.27 million days of economically inactivity have been prevented. The transition to risk-based surveillance increases targeting of control measures and allows to minimize the risks of environmental pollution, to prevent the violation of hygienic requirements of standards by business entities and, accordingly, to substantially reduce the medical and demographic losses associated with the factors of the country's habitat.

The article presents approaches to the establishment of criteria (requirements) of radiation safety to the decontaminated areas of the territory, buildings and decommissioned facilities of use of atomic energy and other types of practical activities with sources of ionizing radiation. The main directions of further use of the decontaminated areas of the territory, buildings, and constructions, including 5 scenarios of restricted and unrestricted use, are determined; the criteria of radiation safety in the term of a dose constraint of a critical group of the population in 0.3 mSv/year living or working on decontaminated objects are established; the controlled parameters of the radiation situation and their levels, as well as the list of radionuclides subject to control are justified. The article presents the values of specific activity (Bq/kg) of residual radioactive contamination of soils and materials of buildings and structures, the radiation dose to the population in which will not exceed 0.3 mSv/year. Based on the presented data, draft sanitary rules and guidelines have been developed.

For the purpose of the development of novel approaches during the commission stage, the hygienic assessment of conditions of training in specially constructed innovative building of SKOLKOVO International Gymnasium was performed. Hygienic examination of innovative architectural and planning solutions, learning conditions and hygienic modeling of the optimal placement of furniture and equipment in multi-faceted educational facilities with panoramic glazing made it possible to predict the provision of the gymnasium with an optimal level of sanitary and epidemiological well-being of students. This is achieved by the innovative layout of the gymnasium building and its territory. Hygienic specification of zoning of both buildings and premises of the educational institution, include the requirements to satisfy the hygienic criteria on children education, motor activity, organization of proper nutrition, and using the building as a center for family leisure. Hygienic modeling of educational furniture and equipment provides optimal conditions (viewing angle) for visual work of students in all multifaceted classes. The obtained data are the basis for amendments to the state sanitary and epidemiological rules and regulations in the field of organization of education and upbringing of children.

As a result of complex hygienic assessment of health of schoolchildren it was found that by the modern schoolchildren has increased the volume and complexity of an academic load, gadgets have strongly entered realities of life, availability of sports sections and groups to overall physical conditioning occupations has decreased, physical activity has decreased, the problem of physiological cost of the academic load significantly exceeding the anatomical and physiological and reduced functionality of the modern schoolchildren. In modern conditions schoolchildren became more sensitive to an adverse effect of environment factors that against the background of a training intensification at the existing problems with ensuring sanitary and epidemiologic wellbeing at schools, insufficiently accurate regulation of admissible levels of influence of innovative factors, has led to formation of risks to health of schoolchildren. At the same time, some of the risks are corrected by preventive measures, while other part requires a system state approach in solving of problematic issues. Results of the work determine the need of correction of the main legislative, organizational and administrative acts on the section of health protection of children and adolescents.

The paper presents the results of a 10-year monitoring of the health of a group of students, totaling more than three thousand people. Methods of research were: full-time, corre-spondence questioning using the «Health» test, which allowed to assess the level of health in terms of health indicators, adaptation, physical condition, and psycho-emotional status. The priority risk factor for the development of diseases is the unsatisfactory physical state. The results of the health program aimed at increasing physical endurance and general nonspecific adaptive reactions of the body. Recommendations for optimization of medical and sanitary services for students of higher educational institutions are grounded.

The article deals with the issues of assessing the health risk of the population from the emissions of the aircraft plant into the atmosphere. According to the results of the first study, high levels of risk were obtained, requiring the implementation of measures to reduce emissions. After the modernization of the plant, the levels of carcinogenic and non-carcinogenic risks decreased by 6,7 and 8,6 times, respectively, to acceptable values, which is confirmed by the results of the second study. The applied methodology of risk assessment, allowed making management decisions to ensure the well-being of the population living in close proximity to the aviation plant.

The article discusses the current problems of preventing of health care-associated infections (HAIs) that arise at the present stage, in particular the spread of antibiotic resistance. It is noted that at present, in terms of reducing the risk of development of resistance of pathogenic microorganisms, it is necessary to take into account the phenomenon of bacterial antibiotic tolerance, which is associated with a decrease in the level of metabolism, cessation of cell growth and shutdown of targets for antibiotics. Similar persistent forms (persisters) of microorganisms ensure the survival of the bacterial population, but not reproduction in the presence of lethal doses of antimicrobial agents. This kind of phenotypic resistance is not inherited, associated with such specific forms as growth in biofilms, and its carriers (persisters) are a reservoir of the spread of resistance genes. The article presents modern possibilities of avoiding the accumulation of persistent forms of HAIs pathogens, including the creation of antibiotic compositions and substances that block the adaptive reactions of the microorganism. A separate chapter is devoted to bacteriophages and the possibilities of their use for the therapy and prevention of HAIs. Modern methods of indicating the pathogens of HAIs, existing on the objects of the hospital environment in the form of biofilms, as well as new methodological approaches to the destruction of such biofilms are proposed.

Annually in Siberia and at the Far East natural disasters cause adverse epidemiological effects that require emergency response of the Supervisory Activities and specialized anti-epidemic teams (SAET) of Rospotrebnadzor. In this connection, the need for objective assessment of various factors and conditions influencing on epidemiological situation in the emergency area occurs. Application of the risk assessment methodology in epidemiology resulted in the four-step algorithm of monitoring of possible epidemiological consequences of natural disasters in the Subjects of the Russian Federation permitting to develop a project of specific operative response of the SAETs in the area of its responsibility. This plan will ensure high level of targeted readiness of Rospotrebnadzor's Regional Activities and SAETs to operate efficiently in the emergency area.

The review presents data on epidemiological risks concerning worldwide spread of enterovirus infection due to intensified migration flows. Outbreak incidence of the most frequently registered forms of enterovirus infection - hand, foot and mouth disease (HFMD) -was analyzed. At the present time, Coxsackievirus A6 plays ever-greater significance in HFMD incidence. The article summarizes currently available scientific data on atypical Coxsackievirus A6-infection clinical manifestations. Details on the tense epidemiological situation concerning Enterovirus D68 that can be the cause of acute flaccid paralysis/myelitis are presented. According to latest recommendations, the molecular genetic techniques are the «golden standard» in diagnostics of enterovirus infection.