We studied the solar radiation effect on the morbidity of malignant skin neoplasms and mortality from them in the Irkutsk region population as one of risk factors. It is established that population's morbidity rates of skin melanoma from 3.3 ± 0.3 to 5.0 ± 0.4 per 100 thousand and other malignant skin neoplasms from 26.0 ± 0.9 to 32.4 ± 0.9 per 100 thousand increased; the mortality rates from them became respectively from 1.6 ± 0.2 to 1.8 ± 0.2 per 100 thousand and from 0.2 ± 0.1 to 0.5 ± 0.1 per 100 thousand in the region during the 2007-2017 period. According to the results of the correlation-regression analysis we found the effect on the morbidity of malignant skin neoplasms for such parameters as direct solar radiation on a horizontal surface, total solar radiation, radiation balance and longwave radiation balance; direct and measured solar radiation influenced mortality from malignant skin neoplasms. To reduce the morbidity of malignant skin neoplasms of the Irkutsk region population, it is necessary to widely educate the population about the dangers of excessive exposure to ultraviolet radiation and inform about local levels of solar radiation according to quality monitoring data.

The paper presents the analysis results of the anthropometric and functional indicators of children between the ages of 7 and 12 years who permanently reside in Surgut. All surveyed schoolchildren (181 persons - 95 boys and 86 girls) were divided by age and sex. The main anthropometric and functional indicators of the cardiovascular system were analyzed. We established that the growth and development of the examined boys and girls corresponded to general biological patterns. It was found that most of the boys have various deviations from normal body weight: the presence of overweight and obesity were recorded in 50 per cent of cases, body weight deficit was determined in 12 per cent of cases. Normal body weight was recorded most often in the group of girls (85 per cent). The stress adaptation mechanisms was characteristic of every third pupil. We found a high percentage of the stress occurrence frequency in all schoolchildren, but girls had it more common than boys. The obtained data once again confirmed the importance of early diagnosis of the cardiovascular system state for determining the organism adaptation level to adverse social and climatic conditions.

We studied manifestation peculiarities of 17-hydroxyprogestron in the morning blood of children in the early neonatal period of development. An assessment of the hormone parameters variation depending on the time of their birth in the implementation of genetic and environmental factors effects was carried out. The intergroup differences in 17-OHProgesterone concentration determined by them were not always associated with the somatic growth indices variability. We presented data indicating that this dependence was regulated at the level of growing organism integrating systems.

The paper presents the physiological researches results of nine migrant professional groups who arrived from south republics of Central Asia to Moscow region of the Russian Federation. We studied the characteristics of adaptation process in labour migrants by the parameters of the cardiovascular and neuromuscular systems. Peculiarities of regulation for heart rate variability (HRV) (changes in the stress-index Sl, AMo values, VLF spectrum power, PARS index) in migrants depending on the neuro-emotional nature of labour activity and the amount of muscle loads are revealed. A pronounced decrease in dynamometric indices of endurance and maximum performance of arms, body and legs muscles by the end of work process has been established. We have developed a method to determine the adaptation process stages with the combined effects of physical severity and neuro-emotional labour intensity, at the same time, poor adaptation increases health disorders risks.

The purpose of the research study was the identification and quantitative assessment of ambient air pollution with risk assessment to public health on the territories of the Orenburg region, bordering the Republic of Kazakhstan. A hygienic assessment of thirteen border municipalities of the Orenburg region was carried out in the paper. We conducted an ambient air analysis for 23 substances, which are under long-term dynamic observation and a non-carcinogenic risk to public health was calculated. It was established that the Western and Central parts of the border territories differing in the qualitative composition of pollutants have the highest level of anthropogenic air pollution. At the same time, the qualitative composition of pollutants in the Western part of the border territory is mainly represented by substances that originate from gas and oil refining facilities. Priority pollutants in the Central part of the border territory are substances that originate from non-ferrous and ferrous metallurgy facilities. Climatic data analysis in the study territory has shown that conditions for the transboundary transfer of atmospheric pollution, both from Kazakhstan and from the Russian Federation can be created with certain meteorological parameters. Non-car cino genic health risk analysis showed the probability of adverse effects development on organs and systems, as well as the probability of malignant neoplasms occurrence in the population living on the border territories. The study justifies and confirms the need to develop a system for monitoring and to assess the probability for transboundary transport of atmospheric pollution, as well as practical recommendations and preventive measures to reduce anthropogenic load.

The paper presents the comparative studies' results of the snow cover quality in the intracity districts of Samara and its surrounding areas at a distance of up to 1000 m from the oil refinery during 2017-2018. We have identified a high extent of pollution on a set of indicators caused by anthropo-technogenic influence (the content of hydrocarbons, suspended solids, difficult-to-oxidize organic matter (by chemical oxygen demand), some metals, etc.). Many important sanitary and hygienic indicators (a significant part of hydrocarbons, benzo[a]pyrene) were not found in filtered snow water, but ones were determined in suspended solids. Comparative analysis for the chemical composition of snow cover on the territory close to the oil refinery and on the streets in Samara revealed no significant differences. In this regard, it is possible to assume a significant contribution of motor vehicles to anthropo-technogenic environmental pollution. It is important to take into account that when snow is melting it can be a source of secondary pollution of soil, waste- and groundwater, therefore it is necessary to periodically monitor the snow cover quality as an integral part of monitoring environment state and take measures to prevent adverse effects of human activities (redistribution of traffic flow of transit heavy vehicle, notification of industrial enterprises in order to reduce noxious emissions for the period of forecasting adverse weather conditions).

We studied the microflora structure and resistance gathered from the biomaterial of patients and the environment objects of various departments at the National hospital of Pediatrics in Hanoi. 140 clinical samples of biomaterials from 74 patients treated in the intensive care unit, the infectious diseases and the gastroenterology departments were studied. A systematic approach including microbiological, epidemiological and statistical research methods was used in carrying out the study. Bacteria of the Enterobacteriaceae family (38.5 per cent) prevailed in the biomaterial of intensive care unit patients. Non-fermentative Gram-negative bacteria (46.5 per cent) occupied the leading positions in the infectious diseases department and Gram-positive bacteria (39.3 per cent) were in the gastroenterology department. Gram-positive flora (60.2 per cent in the intensive care unit and 50.7 per cent in the infectious diseases department) prevailed in the microflora structure gathered from hospital environment objects. We identified the prevalence of bacteria of the genus Enterobacteriaceae and non-fermentative Gram-negative bacteria with a wide spectrum of resistance in the departments of the National Hospital of Pediatrics.

We analyzed time series with tick-borne encephalitis morbidity data and vaccination against it in West Siberia. The study showed the presence of cointegration for time series belonging to different administrative regions of the territory.This implies the existence of common determining factors affecting the epidemic process development of tick-borne encephalitis in the regions of West Siberia.

We studied the effect of the substance acetyl-N-cysteine-L on cholera Vibrio. Its minimum inhibitory concentration for the strains of Vibrio cholerae El Tor O1 and O139 serogroup was 1-2.5 mg/ml in solid nutrient media - Martin's agar (pH 7.6) and LB (pH 7.2), while in Bhascaran synthetic medium, using glucose (0.1per cent) as the sole carbon source, N-acetyl-β-D-glucosamine (0.05 per cent) or colloidal chitin (0.027 per cent) it was reduced to 50-250 μg/ml. The ability of the substance acetyl-N-cysteine-L substance to suppress the activity of the purified enzyme N-acetyl-β-D-glucosaminidase (chitobiasis) was found. Antibacterial effect detected of the substance acetyl-N-cysteine-L against the strains of Vibrio cholerae El Tor O1 and O139 serogroups with different epidemic significance (presence / absence of ctxAB and tcpA genes) indicates the advisability of considering the issue on the possibility of including this substance in composition of solution components used in the rehydration therapy of diarrheal diseases cases

We examined of the oral cavity of 174 HIV-infected patients who are on dispensary supervision and treatment in the Bryansk Center for the prevention and control of AIDS and infectious diseases with the implementation of a complex of bacteriological and parasitological studies. The predominance of non-albican species, as well as mixed infections with two or more species of fungi of the genus Candida were shown.

The paper presents the analysis of Vibrio cholerae El Tor strains antibiotic resistance gathered from environmental objects on the territory of the Russian Federation during 2007-2016. We determined the sensitivity of 268 strains of V. cholerae El Tor to 12 antibacterial drugs by the method of serial dilutions in a dense nutrient medium. The strains showed resistance to 1-7 antibacterial drugs. The emergence of quinolone resistance in polyresistant strains of V. cholerae El Tor limits the choice of effective etiotropic therapy and aggravates the unfavorable prognosis for cholera.