Results analysis of the current system of providing medical care to workers of industrial enterprises of the Perm Krai revealed its insufficient effectiveness in terms of risks communication to employees health. The purpose of risk communication to employees is to provide them with reliable and scientifically based information about health risk factors associated with harmful chemical factors, risk levels, necessary and implemented risk management measures, as well as about ways and means of individual prevention of health problems. A survey of enterprises employees, medical staff of health centers and medical organizations showed that more than half of the respondents did not know about the features of the production process of the enterprise, harmful occupational factors at workplaces and occupational risks. It seems expedient to improve the process of risk communication to the health of all interested parties, and when preparing materials about the risks to the workers' health, one must take into account the peculiarities of perception of this type of information.

High levels of industrial development of the region's areas caused long-term and continuous of habitat objects pollution. Based on socio-hygienic monitoring data, over 70 per cent of the Sverdlovsk Region population is exposed to a set of various chemicals, and children constitute the most sensitive risk group. Lead, cadmium and arsenic are priority contaminants of the habitat in industrial cities and towns of the region. According to the integral estimates, chemical contamination of the habitat by these toxicants forms non-carcinogenic risks to public health. The established non-carcinogenic health risks are confirmed by social and hygienic monitoring indicators of the children chronic morbidity level in organized groups and indicate a statistically significant excess compared with the average regional indicators. According to the mathematical modeling data, statistically significant interrelations were found between the content of lead, cadmium, arsenic in environmental objects and the biomonitoring results.

We analyzed the characteristics of the immunoregulatory parameters of the child population (94 people) aged 5 to 10 years exposed to aluminum. The control group included 45 children, matched by age and sex, living in areas not exposed to aluminum. The study consisted of determining the content of IgG specific to aluminum, total IgE (hypersensitivity indicators) and phagocytic-active cells. A study of CD-markers of cell differentiation and intracellular markers for assessing the apoptosis system (absolute and relative suppressor T-cell receptors CD127-, Bax, anti-apoptotic protein Bcl-2 and proapoptotic cell death receptor CD95+) was performed. As a result of the research, it was reliably established that in the examined child population there are violations of the cellular immunity, which manifest themselves in a decrease in phagocytic activity by the criterion of absolute phagocytosis (42 per cent), relative phagocytosis (56 per cent) and phagocytic number (75 per cent) (for example, decrease in phagocytic activity of cells compared with control was 1.2-1.5 times), activation of absolute and relative suppressor T-cell receptors CD127-, Bax deficiency, antiapoptotic protein Bcl -2 and the proapoptotic cell death receptor CD95+ (p < 0.05) responsible for apoptosis, relative to the reference values. There is a significant increase compared with the norm of specific IgG to aluminum in 44 per cent of children of the observed group and an increase in the level of total IgE by more than 1.4 times compared to the control group (p < 0.05)

We studied the functional state of the cardiovascular system in 997 schoolchildren of Ufa and 597 students of the Bashkir State Medical University with different levels of physical activity. All subjects were divided into 3 groups depending on the level of physical activity: the first group (control) consisted of schoolchildren and students, which do not involve in sports outside the school and university programs, with the lowest physical activity compared with other groups; the second group included persons with an average level of physical activity, who in addition to physical education classes independently engage in physical culture: running, walking, outdoor games and daily morning exercises; the third group consisted of schoolchildren and students regularly engaged in sports clubs and sections, having the highest level of physical activity. The following hemodynamic parameters were calculated: systolic blood volume, minute blood volume, pulse pressure, fatigue coefficient, blood circulation efficiency ratio, Robinson index. The data obtained for each group were subjected to statistical analysis separately for males and females in the age aspect. We have established the positive influence of regular physical education and sports on the metabolic and energy processes in the heart, which in turn leads to an improvement in the main indicators of the cardiovascular system. Thus, among schoolchildren and students regularly engaged in physical culture and sports, significantly lower values of minute blood volume, blood circulation efficiency ratio, endurance coefficient, Robinson index and high values of systolic blood volume, pulse pressure were noted. The presence of reliable direct correlation of the weak degree of physical culture and sports with the majority of studied hemodynamic parameters was revealed.

The paper presents the study results of the dynamics in the erythroid indices of peripheral blood in children of the early postnatal period ontogenesis. All of them were healthy, showed no developmental defects. Based on the results of biometric analysis of the data obtained, the significance of genetic and environmental factors in the identified dynamics was determined. It was largely caused by the influence of natural factors caused by cosmophysical processes during children's development years, such as an increase in the indicators of various types of radiation and basic indexes of solar activity. We conducted a quantitative assessment of their influence on the variability of all erythrocyte indices.

We presented the data on the study of the working conditions of female workers engaged during concentrating on non-ferrous metal ores at the mining and processing plant, the frequency of gynecological pathology, as well as the retrospective analysis results of the course of pregnancy and labor. It has been established that the working conditions during concentrating on non-ferrous metal ores increase the risk of gynecological diseases and complications in the course of pregnancy and labor. Key

We conducted an analysis of occupational bronchial asthma prevalence among workers in various economic sectors of the Republic of Bashkortostan.The most cases of occupational bronchial asthma are registered among workers of healthcare and the provision of social services, manufacturing, production and distribution of electricity, gas and water, etc.

Polymeric fibrous ion-exchange materials based on polyacrylonitrile matrix, produced in the form of cation-exchanger KN-1 and anion-exchanger AS-1 were the object of the study. We studied the sorption properties of these materials to heavy metal salts and products of their chemical transformation with flotation reagents. According to obtained results, exchange processes have high speed and materials are characterized by high value of absorption - up to 250 mg/g. The introduction of a cascade filtration scheme ensures the treatment of highly contaminated multicomponent industrial wastewater to levels that comply with the hygienic requirements. The advantages of the materials under study are the possibility of their repeated regeneration (by acid and alkali) without losing their original properties and the possibility of concentrating the desorbed metals for the purpose of their recycling again.

We presented the assessment results of the potential epidemic risk level (PERL) of conditions for centralized drinking water supply and recreational water use, as potential epidemiological risks for 85 subjects of the Russian Federation. High level of potential epidemic risk of centralized drinking water supply conditions for 21 subjects of the Russian Federation and increased level taking into account water quality, water supply of the population, isolation of pathogenic bacteria, virus markers and registration of the morbidity rate of acute intestinal infections with the implementation of water factor of pathogens transmission for 60 subjects have been established. When assessing recreational water use, a high level of potential epidemic risk was determined in 39 subjects, an increased level of potential epidemic risk was determined in 30 subjects, which indicates the probability of the waterway for the spread of the cholera pathogen and other acute intestinal infections of bacterial and viral etiology. It is planned to use in conjunction with other data in determining the epidemic potential of the subject.

We conducted a comparative analysis of the parenteral viral hepatitis B and C (HBV and HCV) prevalence and their molecular genetic characteristics among prisoners of persons diagnosed with HIV infection (41 samples), HIV-positive free citizens (187 samples) and «conditionally healthy population» with the lack of information about the presence of a diagnosis of chronic viral hepatitis of any etiology and HIV infection (231 samples). Immunological and molecular biological research methods were used. Obtained data analysis showed that the prevalence of infection markers with viruses of parenteral hepatitis was significantly higher in the groups of HIV-positive individuals (imprisoned and freemen). The HBsAg-negative form of the disease was determined among the HIV-positive free population and in the «conditionally healthy population». Over the past 10 years (2009-2018), the proportion of HIV-positive prisoners in custody of people with HCV monoinfection doubled, HBV was increased in 8.7 times. Significant decrease in the combined infection of HBV and HCV of this contingent was found. Given this decrease in the penitentiary system in HIV-positive individuals, the overall burden of HBV infection (both in mono form and coinfection with HCV) significantly (5.3 times) decreased, which can be attributed to successful widespread vaccination against hepatitis B in Russia. The most common HCV genotypes among HIV-positive individuals were 1b and 3a, genotypic structure of HBV prevailed genotype D.

We described the results of studying the stability of the main indicators of medicalnroduct quality for in vitro diagnostics - diagnostic fluorescent tularemia dry immunoglobulins RIF-Tul-StavNIPCHI, developed on the basis of Stavropol Anti-Plague Institute of Rospotrebnadzor to justify the shelf life and recommended storage conditions when used on a real scale time and accelerated research methods. At the same time, one of the main criteria for the study of stability is its study during sample storage not only in the primary packaging of an industrial output, but also after the first opening of the package, during the use period of the reconstituted preparation. On the basis of data obtained in both long-term and accelerated trials, a shelf life of three years is recommended. It was experimentally proved that during this period of time, the quality indicators of the drug remain at a level one that complies with the requirements of technical and operational documentation. In the course of application the recovered product demonstrates stability of its biological and physical-and-chemical properties within 5 days at a storage temperature of 2 to 8°С.