There were established physiological criteria of adaptation of migrant workers in relation to different levels of the neuron-emotional and physical stress under their combined effect and the social and psychological conditions of the environment, for the development of medical and social support of migrant workers.

There were studied the working conditions of duck-rearing workers. It is proved that occupational hazards are presented by a combined effect of the dust of plants and animals, as well as biological factor of microbial contamination of the air in the working area. There was identified presence of leading occupational hazards, which is the cause of bronchopulmonary diseases.

There were offered scientific and methodical bases of health risk assessment to schoolchildren, the organization of monitoring of education and training conditions at regional and municipal levels based on results of 1000-point system of assessment of sanitary and epidemiologic wellbeing level of the educational organizations with the subsequent transfer of results of point assessment in indicators of risk of damage to the health, having a dimensional interval from 0 to 1. For each value of risk of damage to health expected indicators of number of cases of violations of health, additional to background size, are defined. It is recommended to use number of additional cases of violations of health of the children and adolescents caused by low level of sanitary welfare of the educational organizations as one of criteria of overall performance of executive authorities of territorial subjects of the Russian Federation, municipalities, educational organizations, class teachers and tutors. The relevance of the results of the work is emphasized with the entry of the Russian Federation in 2018 in a decade of the childhood defining that the family and the childhood remain priorities of our state and society for the long term.

The indicators of the physical development of 3225 schoolboys from St. Petersburg from 7 to 17 years old were studied. Assessment of the level and harmony of physical development was carried out in accordance with the WHO standards («WHO Growth Reference 2007») using the program «WHO AnthroPlus». The asymmetry of body length indices with a significant representation of tall school children (1.9-10.9 %) is established. The high level of disharmonious variants of physical development, caused by overweight and obesity (16.4-38.2%) was revealed in the schoolchildren surveyed. The necessity of developing a complex of preventive programs aimed at the formation of a healthy lifestyle, balanced nutrition and increasing the motor activity of the younger generation is substantiated.

There were conducted biometric studies and quantitative assessment of variability of indexes of white blood cell count of healthy children of the first year of life (data of the biometric analysis are presented in graphic form). It was revealed that the total number of white blood cells in 78,7 % cases was determined genetically, defining differences in variability of indexes at boys and girls. At the same time cells of a granulocytes row expressed such feature only in 12,2 % of cases. Change in the content of granulocyte row cells in the peripheral blood of children of the first year of life in the conditions of the non-ionizing radiation of natural origin demonstrates the formation of a response of adaptation system components. The data on dynamics of the relations of granulocytes and lymphocytes (indexes) obtained by authors have a theoretical and applied significance for development of criteria for evaluation the functional condition of adaptation system and health of children.

The performed analysis of the effect of chemical factors on the sufficiency of adaptive responses of children showed that high-level exposure to chemical xenobiotics leads to inadequate adaptive response. It is represented by 16,5 % increase of children with insufficient adaptation level and 4,3 % increase of children with adaptation failure. Children, exposed to the high level of chemical xenobiotics, had high activity of phase I-II detoxification enzymes, especially cytochrome CYP1A1 and glutathione S-transferases (GSTMI and GSTTI). Large percentage of children had heterozygous deletion of these above-mentioned genes.

An analysis of the concentration of Mn in drinking water samples collected 425 of the Khanty-Mansiysk autonomous region: 228from localities with high-quality drinking water purification and 198-with poor quality. Overstepping the MPC in most water samples with poor-quality clean it up. Content of Mn in investigated hair 468 adult residents of Khanty-Mansiysk autonomous region. Overstepping the average values of the element concentrations in hair of all those surveyed, significantly (p = 0.005) higher among residents of settlements with poor-quality drinking water purification. Excessive accumulation of Mn in human body, along with other factors, can potentiate the development of disease pathogenesis based on oxidative stress (primarily, cardiovascular), as well as thyroid disease, musculoskeletal system, iron deficiency anemia, etc.

The article is devoted to the evaluation of the level of pollution of snow cover in a large industrial city. There were identified priority pollutants that form a health risk. There was presented the dynamic of changes of pollution level of priority pollutants. In the long-term dynamics was shown that these indicators continue to contribute to anthropogenic pollution of the city. Melting snow can act as a source of secondary contamination of soil, wastewater and groundwater, therefore periodic monitoring its status is an integral part of monitoring the state of the environment.

There was considered the approach, combining the use of the cyanobacteria Synechococsus SP. PCC 6301 culture diffusion and biotesting method by identifying structural changes of cellular proteins (Ap index) at various external influences and recorded by internal reflection infrared spectroscopy. This approach allows to evaluate the quality of the water medium in environmental monitoring as natural watercourses in situ and in the laboratory conditions.

In 2016 and 2017 the study and analysis of the prevalence of opportunistic pathogenic microorganisms (OPM), resistant to antibacterial drugs in the water reservoirs of Rostov-on-Don were carried out. 1522 strains were isolated and 101 species of microorganisms were identified. In 2016 the percentage of nonfermentative microorganisms (NFM) was 45,9 %o, Enterobacteriaceae - 28,6 % and Aeromonadaceae - 24,9 %. In 2017 dominating were the representatives of Aeromonadaceae (39,1 %) and Enterobacteriaceae (37,5 %), the portion of NFM amounted to 23,0 %. The results of OPM antibiotic resistance study demonstrate that in 2017 the proportion of sensitive and monoresistant bacteria considerably decreased, and the number of strains with multiple antibiotic resistances increased. The resistant strains isolated from the external environment should be considered as possible sources of threats to biological security.

The unstable epidemiologic situation regarding enterovirus infection against the background of strong international interaction increases the risk of importation of the pathogens in the Russian Federation. The aim of the research was to evaluate the epidemiologic risks of importation of the enterovirus infection in the Khabarovsk region. Molecular epidemiologic analysis was performed for 481 samples obtained from sewage as well as clinical material from patients with enterovirus infection and exposed persons. The phylogenetic reconstruction was performed according with the Bayesian modeling approach. The molecular epidemiologic research has shown that in the Khabarovsk region enteroviruses of group B (Coxsackievirus B4, B5, ECHO 6, ECHO 9, ECHO 30) were dominant. The molecular-clock analysis used in order to evaluate evolutionary distances highlighted the epidemiologic connection between the cases of enterovirus infection diagnosed in the Khabarovsk region and other regions of the Russian Federation, China, Netherlands and India. The study revealed a potential risk of introduction of the following enteroviruses in the Khabarovsk region - Coxsackievirus B4, B5, ECHO 6, ECHO 9, ECHO 30 from countries of the Asian-Pacific Region, Europe and other regions of the Russian Federation.

New technologies based on remote sensing, has been actively developing now for the increasing the effectiveness of nature plague foci monitoring. The unmanned aerial vehicle (UAV) «GeoScan-101» was used for monitoring and for orthophoto creating. The monitoring was carried out at Caspian nature plague focus on a stationary square 4 ha. The accounting of rodents' holes had been implemented previously. Gerbils Meriones tamariscinus is the host of plague microbe in the Caspian natural plague focus. The monitoring using UAV allows identifying 78,26 % of Meriones tamariscinus holes as well as Microtus socialis and Ellobius talpinus. The comprehensive using remote sensing from space and data from drone (a high-resolution picture in real time) for elaboration data of remote sensing allows increasing the effectiveness of nature plague foci survey, where the hosts have the holes small diameter: the gerbils' genus Meriones and the voles genus Microtus.