Sanitary Protection of the Territory: Specific Aspects of the Dynamics and Intensity of the Spread of Viral Respiratory Infections in the Rostov Region in 2005–2022

Introduction: The epidemic process of acute viral respiratory infections, including influenza and the novel coronavirus disease, is characterized by seasonality and depends on the spectrum of circulating viruses and social factors in a particular area.

Objective: To identify characteristics of the dynamics and intensity of manifestations of the epidemic process of viral respiratory infections typical of certain groups of administrative territories of the Rostov Region.

Materials and methods: We analyzed annual and monthly (over the season and long-term) incidence rates for 17 years (2005–2022) based on federal statistical observation data (Forms 1 and 2, Information on infectious and parasitic diseases) about cases of acute viral respiratory infections and influenza among the population of the Rostov Region, infectious or parasitic disease notifications (Form 058/u), and reports of the Office of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) in the Rostov Region (State Reports on the sanitary and epidemiological wellbeing of the population of the Rostov Region) on disease rates. Statistical data analysis was performed using Statistica 12 (StatSoft Inc., Tulsa, OK, USA). Retrospective and clinical epidemiology methods were used.

Results: We established that children under 14 years of age were most vulnerable to novel respiratory viruses: in the 2010–2011 and 2019–2020 seasons, the incidence rates of viral respiratory infections in them were 81,902.9 %000 and 51,095.2 %000, respectively. The etiological analysis showed that in September to November, 87.9 % of all cases were induced by non-influenza respiratory viruses. The development of the epidemic process was determined by socio-economic characteristics of different groups of administrative territories. Based on incidence rates, the administrative territories of the Rostov Region were divided into three groups: the city of Rostov-on-Don, the Rostov urban agglomeration, and the Rostov agricultural agglomeration, the latter consisting of 36 municipal districts. Importation of pathogens into the administrative center and urban agglomeration led to the rapid spread of diseases among the urban population, while in the agricultural agglomeration, they manifested themselves within local foci.

Conclusion: The established specifics of the spread of infections in different groups of territories can be used to predict and model the epidemiological situation, including in cases of emergence of new viruses.

1. Slis SS, Kovalev EV, Kononenko AA, et al. Features of the long-term dynamics of morbidity of the population of the Rostov region with acute respiratory viral infections and influenza. Public health and habitat. 2021;1:63-70. (In Russ.) doi: 10.35627/2219-5238/2021-334-1-63-70

2. Belichenko TN, Chuchalin AG. Morbidity and mortality of the Russian population from acute respiratory viral infections, pneumonia and vaccine prophylaxis. Therapeutic Archive. 2018;90(1): 22-26. (In Russ.) doi: 10.26442/terarkh201890122-26

3. Karetkina G.N. Influenza, ARVI: problems of prevention and treatment. Infectious diseases: news, opinions, training. 2015;4:25-34. (In Russ.)

4. Zhigarlovsky BA. Temporary disability in influenza and SARS in the Russian Federation and Moscow. Epidemiology and Vaccination Prevention. 2019;18(3):4–12. (In Russ.) doi: 10.31631/2073-3046-2019-18-3-4-12

5. Semenenko TA, Akimkin VG, Burtseva EI, et al. Features of the epidemic situation for acute respiratory viral infections, taking into account the pandemic spread of COVID-19. Epidemiology and Vaccination Prevention. 2022;21(4):4-15. (In Russ.) doi:10.31631/2073-3046-2022-21-4-4-15

6. Trilla A, Trilla G, Daer C. The 1918 “Spanish Flu” in Spain. Clin Infect Dis. 2008; 47 (5): 668–73. doi:10.1086/590567

7. Monto AS, Fukuda K. Lessons from influenza pandemics of the last 100 years. Clin Infect Dis. 2020; 70 (5): 951–7. doi:10.1093/cid/ciz803

8. Erkoreka A. Origins of the Spanish Influenza pandemic (1918-1920) and its relation to the First World War. J Mol Genet Med. 2009 Nov 30;3(2):190-4. doi: 10.4172/1747-0862.1000033. PMID: 20076789; PMCID: PMC2805838

9. Morozova OM, Troshina TI, Morozova EN, Morozov AN. The Spanish flu pandemic of 1918 in Russia. Questions a hundred years later. Journal of Microbiology, Epidemiology and Immunobi-ology. 2021;98(1):113–124. (In Russ.) doi.org/10.36233/0372-9311-98

10. Briko NI. 100 years of the "Spanish flu" pandemic. The evolution of the influenza virus and the development of influenza vaccines. Epidemiology and Vaccination Prevention. 2018;17(4): 68–97. (In Russ.) doi:10.31631/2073-3046-2018-17-4-68-97

11. Tsvetkov VV, Deeva EG, Danilenko DM. et al. Molecular genetic factors of pathogenicity of influenza A(H1N1)pdm09 virus. Epidemiology and infectious diseases. 2014;19(4): 4-11

12. Noskov AK, Vishnyakov VA, Chesnokova MV. et al. Population Migration as a Risk Fac-tor of Transboundary Importation of Dangerous Infectious Diseases in the Siberian and Far Eastern Federal Districts. Epidemiology and Vaccinal Prevention. 2015;14(6):35-42. (In Russ.) doi.org/10.31631/2073-3046-2015-14-6-35-42

13. Ignat’Eva ME, Samoilova IYu, Budatsyrenova LV. et al. Peculiarities of the influenza epi-demics during 2015-2016, 2016-2017 and 2017-2018 seasons in the Republic of Sakha (Yaku-tia). Public Health and Life Environment. 2019;(5):28-33. (In Russ.)

14. Soboleva EG, Kovalev EV, Slis SS. et al. Features of the spread of a new coronavirus infec-tion in the territory of municipalities of the Rostov region. Journal of Microbiology, Epidemiology and Immunobiology. 2022;99(4):410–419. (In Russ.) doi.org/10.36233/0372-9311-195

15. Ermolenko OD, Ermolenko VP. Agriculture of the Rostov region during the agrarian re-form: the current state and prospects of development. Scientific Journal of the Russian Research Institute of Land Reclamation Problems. 2017;25(1): 244-255. (In Russ.)

16. Karpova LS, Burtseva EI, Popovtseva NM, Stoliarova TP. Comparison of influenza epi-demics in Russia in 2009 and 2011 caused by the pandemic influenza A(H1N1) virus. Epidemiolo-gy and Vaccination Prevention. 2011;5(60):6-15. (In Russ.)

17. Karpova LS, Pelikh MYu, Stolyarov KA. et al. The flu pandemic in Russia as part of the global spread of influenza A(H1N1)pdm09 in 2009-2011. Questions of virology. 2012; 6: 26–30. (In Russ.)

18. Karpova LS, Sominina AA, Burtseva EI. et al. Comparison of influenza epidemics in Rus-sia caused by the pandemic influenza A(H1N1)pdm09 virus in the period from 2009 to 2013. Questions of virology. 2015; 60(3): 19–24. (In Russ.)

19. Slis SS, Kovalev EV, Ianovich EG. et al. The main risks of the formation of an emergency epidemic situation associated with new respiratory viruses. Epidemiology and Vaccination Preven-tion. 2022;21(2):74-82. (In Russ.) doi.org/10.31631/2073-3046-2022-21-2-74-82

20. Popova AIU, Ezhlova EB, Melnikova AA. et al. On the preliminary results of the 2015-2016 epidemic season for influenza and acute respiratory viral infections in the Russian Federation. Consilium Medicum. 2016; 18 (3): 8–11

21. Kovalev EV, Slis SS, Nenadskaia SA. et al. Experience in carrying out organizational and preventive measures in the Rostov region during the 2015-2016 flu epidemic season. Epidemiology and Vaccination Prevention. 2017. 16 (2). 88–95. (In Russ.) doi.org/10.31631/2073-3046-2017-16-2-88-95

22. Iаtsyshina SB, Mamoshina MV, Elkina MA. et al. The prevalence of pathogens of AR-VI, influenza and COVID-19 in people without symptoms of respiratory infection. Journal of Mi-crobiology, Epidemiology and Immunobiology. 2021;98(4):383–396. (In Russ.) doi.org/10.36233/0372-9311-152

23. Kovalev EV, Slis SS, Yanovich EG. et al. Some features of the epidemic spread of a new coronavirus infection (COVID-19) in the Rostov region. Medical Bulletin of the South of Russia. 2020;11(4):99-106. (In Russ.) doi: 10.21886/2219-8075-2020-11-4-99-106

24. Akimkin VG, Popova AYu, Ploskireva AA. et al. COVID-19: the evolution of the pan-demic in Russia. Message I: Manifestations of the epidemic process COVID-19. Journal of Micro-biology, Epidemiology and Immunobiology. 2022;99(3):269–286. (In Russ.) doi.org/10.36233/0372-9311-276.

25.