Issues of Safety of Herb Mixes and Food Supplements Contaminated with Tropane Alkaloids: A Review

   Background: Nutritional supplements, herbal assemblages, and herbal teas are of particular interest in the global market of specialized food products, with the issues of a safe use becoming particularly relevant in the light of the reports on their potential contamination with tropane alkaloids, which content ranges from 0.01 % to 3 % depending on the type of raw materials.
   Objective: Analysis of the safety of dietary supplements, herbs and herbal teas contaminated with tropane alkaloids, based on data currently presented in domestic and international scientific publications.
   Materials and methods: We did a review of Russian and English language scientific literature published in 2001–2021, found on Scopus, PubMed and RSCI databases for tropane alkaloids. The initial sample included 49 articles, of which 19 articles were excluded following a primary analysis. The selection criteria included the presence of classification of tropane alkaloids, their contents in herbs and foods, methods of detection, and potential human health effects. We selected 30 full-text publications meeting the above criteria. The study results were systematized by the type of intervention.
   Results: The analysis showed that the content of tropane alkaloids in some herbal teas by the sum of atropine and scopol-amine can exceed the established level of a single safe intake (0.016 µg/kg body weight). Since scopolamine is a derivative of hyoscyamine (atropine), safety of foods and raw materials should be assessed by their content of atropine that will allow effective monitoring of contamination with tropane alkaloids of all types of the specified food products for the purpose of their safe use.
   Conclusion: For the safe use of herbal preparations and plant-based dietary supplements, it is recommended to monitor these types of food products for the presence of tropane alkaloids in them. It is advisable to develop a method for their analysis using high-performance liquid chromatography coupled with mass spectrometry.

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