Experimental assessment of the nanoparticles toxicity of nickel oxide in two sizes in the subchronic experiment
Abstract
We conducted a comparative assessment of the nickel oxide nanoparticles toxicity (NiO) of two sizes (11 and 25 nm) according to a number of indicators of the body state after repeated intraperitoneal injections of these particles suspensions. At equal mass doses, NiO nanoparticles have been found to cause various manifestations of systemic subchronic toxicity with a particularly pronounced effect on liver, kidney function, the body's antioxidant system, lipid metabolism, white and red blood, redox metabolism, spleen damage, and some disorders of nervous activity allegedly related to the possibility of nickel penetration into the brain from the blood. The relationship between the diameter and toxicity of particles is ambiguous, which may be due to differences in toxicokinetics, which is controlled by both physiological mechanisms and direct penetration of nanoparticles through biological barriers and, finally, unequal solubility.
About the Authors
M. P. Sutunkova
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
B. A. Katsnelson
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
L. I. Privalova
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
S. N. Solovyeva
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
V. B. Gurvich
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
I. A. Minigalieva
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
S. V. Klinova
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
T. V. Bushueva
Ekaterinburg Medical Research Center for Prevention and Health Promotion of Industrial Workers of Rospotrebnadzor
Russian Federation
Russian Federation
V. Ya. Shur
Ural Federal University named after the first President of Russia B.N. Yeltsin
Russian Federation
Russian Federation
I. E. Valamina
Ural State Medical University of the Russian Ministry of Health
Russian Federation
Russian Federation
A. E. Tsaregorodtseva
Ural State Medical University of the Russian Ministry of Health
Russian Federation
Russian Federation
E. V. Shishkina
Ural Federal University named after the first President of Russia B.N. Yeltsin
Russian Federation
Russian Federation
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Review
For citations:
Sutunkova M.P., Katsnelson B.A., Privalova L.I., Solovyeva S.N., Gurvich V.B., Minigalieva I.A., Klinova S.V., Bushueva T.V., Shur V.Ya., Valamina I.E., Tsaregorodtseva A.E., Shishkina E.V. Experimental assessment of the nanoparticles toxicity of nickel oxide in two sizes in the subchronic experiment. Public Health and Life Environment – PH&LE. 2018;(12):30-35. (In Russ.)
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