Peculiarities of adaptive response and genetic polymorphism in children under the effect of different chemical factors
Abstract
The performed analysis of the effect of chemical factors on the sufficiency of adaptive responses of children showed that high-level exposure to chemical xenobiotics leads to inadequate adaptive response. It is represented by 16,5 % increase of children with insufficient adaptation level and 4,3 % increase of children with adaptation failure. Children, exposed to the high level of chemical xenobiotics, had high activity of phase I-II detoxification enzymes, especially cytochrome CYP1A1 and glutathione S-transferases (GSTMI and GSTTI). Large percentage of children had heterozygous deletion of these above-mentioned genes.
About the Authors
A. G. Setko
Orenburg State Medical University of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
N. P. Setko
Orenburg State Medical University of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
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Review
For citations:
Setko A.G., Setko N.P. Peculiarities of adaptive response and genetic polymorphism in children under the effect of different chemical factors. Public Health and Life Environment – PH&LE. 2018;(2):25-27. (In Russ.)
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