The prevalence of different variants of Helicobacter pylori genotypes in families of patients with helicobacter-associated diseases
K. M. Perfilova,
I. V. Shutova,
N. V. Neumoina,
M. V. Neumoina,
T. A. Troshina,
T. Y. Butina,
I. V. Kuznetsova https://doi.org/10.35627/2219-5238/2019-321-12-66-70
Abstract
The article presents the results of the examination of relatives of the patients with chronic H. pylori-assoe ciated gastritis. The genes of H. pylori pathogenicity were investigated by PCR to determine possible intrafamilial transmission of the infection. We established that in families of the patients with chronic gastritis, H. pylori was found in more than 60 % of relatives. The most similar spectrum of the genes of H. pylori pathogenicity was found in the samples of spouses, as well as in the mothers and the children. The study of H. pylori genovariant helps es-a tablish the mechanisms and ways of transmission of the infection, identify people infected with the microorganism with the most pronounced pathogenic potential and requiring therapy.
About the Authors
K. M. Perfilova
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
I. V. Shutova
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
N. V. Neumoina
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
M. V. Neumoina
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
T. A. Troshina
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
T. Y. Butina
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
I. V. Kuznetsova
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
References
1. Барановский А.Ю., Беляев А.М., Кондрашина Э.А Показатели заболеваемости и смертности от болезней органов пищеварения в СЗФО России и меры, принимаемые по их снижению // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2019. Т. 29. № 1. С. 36-46.
2. Бордин Д.С., Войнован И.Н., Колбасников С.В., Эмбутниекс Ю.В. Методы диагностики инфекции Helicobacter pylori в клинический практике // Терапевтический архив. 2018. № 12. С. 133-139.
3. Здравоохранение в России. 2017: Статистический сборник / Под ред. Г.К. Оксенойт М.: Росстат, 2017. С. 29.
4. Ивашкин В.Т., Маев И.В., Лапина Т.Л., Шептулин А.А., Трухманов А.С., Баранская Е.К., Абдулхаков Р.А, Алексеева О.П., Алексеенко С.А, Дехнич Н.Н., Козлов Р.С., Кляритская И.Л., Корочанская Н.В., Курилович С.А., Осипенко М.Ф., Симаненков В.И., Ткачев А.В., Хлынов И.Б., Цуканов В.В. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018. Т. 28. № 1. С. 55-70.
5. Исаева Г.Ш., Валиева Р.И. Биологические свойства и вирулентность H. pylori // Клиническая микробиология и антимикробная химиотерапия. 2018. Т. 20. № 1. С. 14-23.
6. Лазебник Л.Б., Ткаченко Е.И., Абдулганиева Д.И., Абжулхаков Р.А. и др. VI национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacter pylori заболеваний (VI Московские соглашения) // Экспериментальная и клиническая гастроэнтерология. 2017. № 2 (138). С. 3-21.
7. Маев И.В., Самсонов А.А., Андреев Д.Н. Инфекция Helicobacter pylori / М.: ГЭОТАР-Медиа, 2016. 256 с.
8. Основные показатели здоровья населения и деятельности государственных медицинских организаций Нижегородской области за 2014 год: Сборник (ред. А.А. Коновалов, Л.Е. Варенова). Нижний Новгород, 2015. 232 с.
9. Шептулин А.А. Основные положения Киотского согласительного совещания по проблеме гастрита, ассоциированного с инфекцией Helicobacter pylori // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016. № 1. С. 53-64
10. Chey WD, Lontiadis GI, Howden CW, et al. ACG Clinical Guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol advance online publication. 10 January 2017. DOI: 10.1038/ajg.2016.563. http://www.nature.com/ajg. (accessed: 25.04.2017).
11. Dadashzadeh K, Ortezamilani M, Somi MH. The prevalence of Helicobacter pylori CagA and IceA genotypes and possible clinical outcomes. Acta medica mediterranea. 2015; 31:1345-1349.
12. Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017; 153:420-429.
13. Lee YC, Chiang TH, Chou CK, et al. Association between Helicobacter pylori eradication and gastric cancer incidence: a systematic review and meta-analysis. Gastroenterology. 2016; 5(150):1113-1124.
14. Mahachai V, Vilaichone R, Pittayanon R, et al. Helicobacter pylori management in ASEAN: The Bangkok consensus report. Focus on clinical aspects of H. pylori infection in Asia and recommendations for clinical management. J Gastroenterol Hepatol. 2018; 1(33):37-56. Available at: https://doi.org/10.1111/jgh.13911. (accessed: 15.06.2018).
15. Malfertheiner P. Helicobacter pylori treatment for gastric cancer prevention. N Engl J Med. 2018; 12(378):1154-1156. https://doi. org/10.1056/NEJMe1800147. (accessed: 19.02.2019).
16. Malfertheiner Р, Venerito М, Schulz С. Helicobacter pylori infection: new facts in clinical management. Curr Treat Options Gastroenterol. 2018; 4(16):605-615.
17. Mamishi S, Eshaghi H, Mahmoudi S, et al. Intrafamilial transmission of Helicobacter pylori: genotyping of faecal samples. Br J Biomed Sci. 2016; 1(73):38-43. DOI: 10.1080/09674845.2016.1150666.
18. Mentis А, Lehours Р, Megraud F. Epidemiology and diagnosis of Helicobacter pylori infection. Helicobacter. 2015; 1(20):1-7.
19. Miftahussurur M, Sharma RP, Shrestha PK, et al. Molecular epidemiology of Helicobacter pylori infection in Nepal: specific ancestor root. PLoS ONE. 2015; 7(10):1-16. Available at: https:// doi.org/10.1371/journal.pone.0134216. (accessed: 30.01.2016).
20. Sedaghat H, Moniri R, Jamali R, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2, and oipA genotypes in patients with upper gastrointestinal diseases. Iranian J Microbiology. 2014; 1(6):14-21.
21. Sugano K, Tack J, Kuipers JE. Kyoto global consensus report on Helicobacter pylori gastritis. GUT. 2015; 9(64):1353-1367.
22. Venerito М, Goni E, Malfertheiner P. Helicobacter pylori screening: options and challenges. Expert Rev Gastroent. 2015; 4(10):28-32.
23. Venneman K, Huybrechts I, Gunter MJ, et al. The epidemiology of Helicobacter pylori infection in Europe and the impact of lifestyle on its natural evolution toward stomach cancer after infection: a systematic review. Helicobacter. 2018; 3(23):e12483. https://doi. org/10.1111/hel.12483. (accessed: 12.03.2019).
24. Yokota SI, Konno M, Fujiwara SI. Intrafamilial, preferentially mother-to-child and intraspousal, Helicobacter pylori infection in Japan determined by mutilocus sequence typing and random amplified polymorphic DNA fingerprinting. Helicobacter. 2015; 5(20):334-342.
Review
For citations:
Perfilova K.M., Shutova I.V., Neumoina N.V., Neumoina M.V., Troshina T.A., Butina T.Y., Kuznetsova I.V. The prevalence of different variants of Helicobacter pylori genotypes in families of patients with helicobacter-associated diseases. Public Health and Life Environment – PH&LE. 2019;(12):66-70. (In Russ.) https://doi.org/10.35627/2219-5238/2019-321-12-66-70
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