Correlations between Elemental Status and Indicators of Oxidative Metabolism in Residents of the Khanty-Mansi Autonomous Okrug with Its Poor-Quality Water Treatment

   Introduction: Trace elements found in natural drinking water can play a key role in making up the chemical composition of the human body in the area of residence.
   Objective: To study the relationship between indicators characterizing the elemental status and oxidative metabolism of residents of the Khanty-Mansi Autonomous Okrug and poor-quality tap water treatment.
   Materials and methods: Hair concentrations of iron, manganese, calcium, magnesium, zinc, and selenium were established in 155 regional residents using atomic emission and inductively coupled plasma mass spectrometry. Contents of the products of lipid peroxidation (lipid hydroperoxide and thiobarbituric acid reactive substances) and antioxidant defense of the body (total antioxidant capacity and thiol status) were determined in blood serum using test kits. The oxidative stress index was calculated as lipid hydroperoxide × thiobarbituric acid reactive substances / total antioxidant capacity × thiol status.
   Results: The residents of the northern Russian cities notorious for poor-quality water treatment have elevated hair levels of Fe and Mn (p < 0.001) and a decreased Se concentration (p = 0.012) combined with a statistically higher level of lipid hydroperoxides, thiobarbituric acid reactive substances, oxidative stress index (p < 0.001), and a low level of antioxidant defense of the body (p < 0.001–0.002). We established a direct correlation between selenium levels in hair and indicators of antioxidant defense status (r = +0,784 ... r = +0,531) and an inverse correlation with lipid peroxidation parameters (r = –0,679 ... r = –0,465). Accumulation of iron and manganese in the human body is closely related to activation of lipid peroxidation (r = +0,472 ... r = +0,413) and suppression of the antioxidant defense status (r = –0,521 ... r = –0,379).
   Conclusion: The observed relationships between the parameters of oxidative metabolism give evidence of a weakening of antioxidant protection and activation of lipid peroxidation in the population of the cities of the Khanty-Mansi Autonomous Okrug supplied with poor-quality tap water.

1. Rakhmanin Yu. A. Actualization of methodological problems of reglamentation of chemical pollutions on the environment. Gigiena i Sanitariya. 2016; 95 (8): 701-707. (In Russ.) doi: 10.18821/0016-9900-2016-95-8-701-707

2. Elpiner L. I. Medical hydrogeology is an independent interdisciplinary branch of the science about groundwater. Gigiena i Sanitariya. 2016; 95 (9): 800-805. (In Russ.) https://cyberleninka.ru/article/n/meditsinskaya-gidrogeologiya-mezhdistsiplinarnyy-razdel-nauki-o-podzemnyh-vodah?

3. Yakubova I. Sh., Mel’tser A. V., Erastova N. V., Bazilevskaya E. M. Hygienic evaluation of the delivery of physiologically wholesome drinking water to the population of St. Petersburg. Gigiena i Sanitariya. 2015; 94 (4): 21-25. (In Russ.)

4. Nelson L., Valle J., King G., et al. Estimating the proportion of childhood cancer cases and costs attributable to the environment in California. Am J Public Health. 2017; 107 (5): 756-762. doi: 10.2105/AJPH.2017.303690

5. Tsunina N. M., Zhernov Yu. V. Health risk assessment of the population in Samara associated with chemical contamination of drinking water. Zdorov’e Naseleniya i Sreda Obitaniya. 2018; (11 (308)): 22-26. (In Russ.) https://www.elibrary.ru/item.asp?id=36498188&

6. Allaire M., Wu H., Lall U. National trends in drinking water quality violations. Proc Natl Acad Sci U S A. 2018; 115 (9): 2078-2083. doi: 10.1073/pnas.1719805115

7. Bouchard M. F., Sauvé S., Barbeau B., et al. Intellectual impairment in school-age children exposed to man - ganese from drinking water. Environ Health Perspect. 2011; 119 (1): 138-143. doi: 10.1289/ehp.1002321

8. Eggers M. J., Doyle J. T., Lefthand M. J., et al. Community engaged cumulative risk assessment of exposure to inorganic well water contaminants, Crow Reservation, Montana. Int J Environ Res Public Health. 2018; 15 (1): 76. doi: 10.3390/ijerph15010076

9. Golubkina N. A., Korchina T. Ya., Merkulova N. N. [Provision of selenium to residents of Surgut, Tyumen region.] Ekologicheskie Sistemy i Pribory. 2004; (3): 48-51. (In Russ.)

10. Ding Z., Hu X. Ecological and human health risks from metal(loid)s in peri-urban soil in Nanjing, China. Environ Geochem Health. 2014; 36 (3): 399-408. doi: 10.1007/s10653-013-9568-1

11. Ngole-Jeme V. M., Fantke P. Ecological and human health risks associated with abandoned gold mine tailings contaminated soil. PLoS One. 2017;12 (2): e0172517. doi: 10.1371/journal.pone.0172517

12. Notova S. V., Kiyaeva E. V., Radysh I. V., Laryushina I. E., Blagonravov M. L. Element status of students with different levels of adaptation. Bull Exp Biol Med. 2017;163 (5): 590-593. doi: 10.1007/s10517-017-3855-2

13. Rapant S., Cvečková V., Fajčíková K., Dietzová Z., Stehlíková B. Chemical composition of groundwater/drinking water and oncological disease mortality in Slovak Republic. Environ Geochem Health. 2017; 39 (1): 191-208. doi: 10.1007/s10653-016-9820-6

14. Korchina T. Ya., Minyaylo L. A., Korchin V. I. Excessive concentration of manganese in drinking water and risk to the health of the population of the northern region. Zdorov’e Naseleniya i Sreda Obitaniya. 2018; (2 (299)): 28-33. (In Russ.) https://cyberleninka.ru/article/n/izbytochnaya-kontsentratsiya-margantsa-v-pitievoy-vode-i-risk-dlya-zdorovya-naseleniya-severnogo-regiona?

15. Mazhaeva T. V., Dubenko S. E., Chirkova I. A. Antioxidants level assessment in the diet of workers contacting with heavy metals at industrial enterprise. Gigiena i Sanitariya. 2016; 95 (2): 165-167. (In Russ.) URL: https://cyberleninka.ru/article/n/izbytochnaya-kontsentratsiya-margantsa-v-pitievoy-vode-i-risk-dlya-zdorovya-naseleniya-severnogo-regiona?

16. Menezes-Filho J. A., de Carvalho-Vivas C. F., Viana G. F., et al. Elevated manganese exposure and school-aged children’s behavior: a gender-stratified analysis. Neurotoxicology. 2014; 45: 293-300. doi: 10.1016/j.neuro.2013.09.006

17. Torres-Agustín R., Rodríguez-Agudelo Y., Schilmann A., et al. Effect of environmental manganese exposure on verbal learning and memory in Mexican children. Environ Res. 2013; 121: 39-44. doi: 10.1016/j.envres.2012.10.007

18. Chiuve S. E., Korngold E. C., Januzzi J. L. Jr., Gantzer M. L., Albert C. M. Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr. 2011; 93 (2): 253-260. doi: 10.3945/ajcn.110.002253

19. Fischer V., Haffner-Luntzer M., Amling M., Ignatius A. Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur Cell Mater. 2018; 35: 365-385. doi: 10.22203/eCM.v035a25

20. Gammoh N. Z., Rink L. Zinc in infection and inflammation. Nutrients. 2017; 9 (6): 624. doi: 10.3390/nu9060624

21. Gröber U., Schmidt J., Kisters K. Magnesium in prevention and therapy. Nutrients. 2015; 7 (9): 8199-8226. doi: 10.3390/nu7095388

22. Kim H. J., Kim N. K., Park H. K., et al. Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area. Eur J Nutr. 2017; 56 (3): 965-971. doi: 10.1007/s00394-015-1144-2

23. Martínez de Victoria E. [Calcium, essential for health]. Nutr Hosp. 2016; 33 (Suppl 4): 341. (In Spanish.) DOI: 10.20960/nh.341

24. Momčilović B. On decoding the syntax of the human hair bioelement metabolism. Mikroelementy v Meditsine. 2017; 18 (2): 54-55. URL: https://journal.microelements.ru/uploads/2017_2/54_18(2)_2017.pdf?v1

25. Skalny A. V., Skalnaya M. G., Tinkov A. A., et al. Hair concentration of essential trace elements in adult non-exposed Russian population. Environ Monit Assess. 2015; 187 (11): 677. doi: 10.1007/s10661-015-4903-x

26. Karpova M. V., Zemlyanova M. A., Mazunina D. L. Biomarkers of cytogenetic disorders under the external environmental isolated exposure of manganese and stable strontium from drinking water. Gigiena i Sanitariya. 2016; 95 (1): 102-105. (In Russ.) URL: https://cyberleninka.ru/article/n/biomarkery-tsitogeneticheskih-narusheniy-pri-vneshnesredovoy-izolirovannoy-ekspozitsii-naseleniya-margantsem-stabilnym-strontsiem?

27. Michalska-Mosiej M., Socha K., Soroczyńska J., Karpińska E., Łazarczyk B., Borawska M. H. Selenium, zinc, copper, and total antioxidant status in the serum of patients with chronic tonsillitis. Biol Trace Elem Res. 2016; 173 (1): 30-34. doi: 10.1007/s12011-016-0634-2

28. Rayman M. P. Selenium and human health. Lancet. 2012; 379 (9822): 1256-1268. doi: 10.1016/S0140-6736(11)61452-9

29. Ercal N., Gurer-Orhan H., Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem. 2001; 1 (6): 529-539. doi: 10.2174/1568026013394831

30. Korchina T. Ya., Korchin V. I. Analysis of glutathione part of the antioxidant protective system of males of the northern region with various levels of human induced pressures. Tekhnologii Zhivykh Sistem. 2019; 16 (3): 47-55. (In Russ.) URL: http://radiotec.ru/ru/journal/14/number/2019-3/article/20082

31. Zhu Y., Carvey P. M., Ling Z. Altered glutathione homeostasis in animals prenatally exposed to lipopoly-saccharide. Neurochem Int. 2007; 50 (4): 671-680. doi: 10.1016/j.neuint.2006.12.013

32. Hatfield D. L., Tsuji P. A., Carlson B. A., Gladyshev V. N. Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem Sci. 2014; 39 (3): 112-120. doi: 10.1016/j.tibs.2013.12.007

33. Halliwell B. Free radicals and antioxidants: updating a personal view. Nutr Rev. 2012; 70 (5): 257-265. doi: 10.1111/j.1753-4887.2012.00476.x

34. Sobiecki J. G., Appleby P. N., Bradbury K. E., Key T. J. High compliance with dietary recommendations in a cohort of meat eaters, fish eaters, vegetarians, and vegans: results from the European Prospective Investigation into Cancer and Nutrition – Oxford study. Nutr Res. 2016; 36 (5): 464-477. doi: 10.1016/j.nutres.2015.12.016

35. Shikh E. V., Makhova A. A. Role of ascorbic acid and tocopherol in the prevention and treatment of diseases from the standpoint of evidence-based medicine. Terapevticheskiy Arkhiv. 2015; 87 (4): 98-102. (In Russ.) doi: 10.17116/terarkh201587498-102

36.