sredobPublic Health and Life Environment – PH&LEЗдоровье населения и среда обитания – ЗНиСО2219-52382619-0788ФБУЗ ФЦГиЭ Роспотребнадзора10.35627/2219-5238/2022-30-5-7-14sredob-967Research ArticleCOMMUNAL HYGIENEКОММУНАЛЬНАЯ ГИГИЕНАHealth Risk Factors of Emissions from Internal Combustion Engine Vehicles: An Up-to-Date Status of the ProblemФакторы риска нарушений здоровья от транспортных выбросов двигателей внутреннего сгорания: современное состояние проблемыhttps://orcid.org/0000-0003-1687-2244МоргуновБ. А.MorgunovB. A.
Моргунов Борис Алексеевич – д.г.н., директор, Институт экологии
Покровский бульвар, д. 11, стр. 2-Е, г. Москва, 101000
Boris A. Morgunov, Dr. Sci. (Geog.), Director, Institute of Ecology
11 Pokrovsky Boulevard, Moscow, 101000
bmorgunov@hse.ruhttps://orcid.org/0000-0002-2600-0522ЧащинВ. П.ChashchinV. P.
Чащин Валерий Петрович – д.м.н., профессор, Институт экологии; главный научный сотрудник; профессор кафедры профилактической медицины
Покровский бульвар, д. 11, стр. 2-Е, г. Москва, 1010002-я Советская улица, д. 4, г. Санкт-Петербург, 191036ул. Кирочная, д. 41, г. Санкт-Петербург, 195067
Valerii P. Chashchin, Dr. Sci. (Med.), Professor, Institute of Ecology; Chief Researcher; Professor, Department of Preventive Medicine
11 Pokrovsky Boulevard, Moscow, 1010004, 2nd Sovetskaya Street, Saint Petersburg, 19103641 Kirochnaya Street, Saint Petersburg, 195067
valerych05@mail.ruhttps://orcid.org/0000-0001-5923-0941ГудковА. Б.GudkovA. B.
Гудков Андрей Борисович – д.м.н., профессор, зав. кафедрой экологии человека
Троицкий пр., д. 51, г. Архангельск, 163061
Andrei B. Gudkov, Dr. Sci. (Med.), Professor, Head of the Department of Human Ecology
51 Troitsky Avenue, Arkhangelsk, 163061
gudkovab@nsmu.ruhttps://orcid.org/0000-0001-6759-5481ЧащинМ. В.ChashchinM. V.
Чащин Максим Валерьевич – д.м.н., старший научный сотрудник, Институт экологии; заведующий НИЛ арктической медицины
Покровский бульвар, д. 11, стр. 2-Е, г. Москва, 101000ул. Кирочная, д. 41, г. Санкт-Петербург, 195067
Maxim V. Chashchin, Dr. Sci. (Med.), Senior Research Fellow, Institute of Ecology; Head of the Research Laboratory of Arctic Medicine
11 Pokrovsky Boulevard, Moscow, 10100041 Kirochnaya Street, Saint Petersburg, 195067
max.chashchin@gmail.comhttps://orcid.org/0000-0002-0135-4594ПоповаО. Н.PopovaO. N.
Попова Ольга Николаевна – д.т.н., д.м.н., профессор кафедры экологии человека
Троицкий пр., д. 51, г. Архангельск, 163061
Olga N. Popova, Dr. Sci. (Tech.), Dr. Sci. (Med.); Professor, Department of Human Ecology
51 Troitsky Avenue, Arkhangelsk, 163061
popova_nsmu@mail.ruhttps://orcid.org/0000-0003-3335-4721НикановА. Н.NikanovA. N.
Никанов Александр Николаевич – к.м.н., руководитель клиники профессиональных заболеваний
2-я Советская улица, д. 4, г. Санкт-Петербург, 191036
Aleksandr N. Nikanov, Cand. Sci. (Med.), Head of Occupational Disease Clinic
4, 2nd Sovetskaya Street, Saint Petersburg, 191036
Томассен Ингвар – к.х.н., старший советник отдела химической и биологической рабочей среды
Pb 5330 Majorstuen, 0304 Осло
Yngvar Thomassen, PhD (Chem.), Senior Adviser, Department of Chemical and Biological Work Environment
Pb 5330 Majorstuen, 0304, Oslo
yngvar.thomassen@stami.noНИУ ВШЭРоссияHigher School of EconomicsRussian FederationНИУ ВШЭ; ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора; ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава РоссииРоссияHigher School of Economics; North-West Public Health Research Center; I.I. Mechnikov North-Western State Medical UniversityRussian FederationФГБОУ ВО «Северный государственный медицинский университет» Минздрава РоссииРоссияNorthern State Medical UniversityRussian FederationНИУ ВШЭ; ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава РоссииРоссияHigher School of Economics; I.I. Mechnikov North-Western State Medical UniversityRussian FederationФБУН «Северо-Западный научный центр гигиены и общественного здоровья» РоспотребнадзораРоссияNorth-West Public Health Research CenterRussian FederationНациональный институт гигиены трудаНорвегияNational Institute of Occupational Health (STAMI)Norway20221006202205714Copyright © Morgunov B.A., Chashchin V.P., Gudkov A.B., Chashchin M.V., Popova O.N., Nikanov A.N., Thomassen Y., 20222022Моргунов Б.А., Чащин В.П., Гудков А.Б., Чащин М.В., Попова О.Н., Никанов А.Н., Томассен Ю.Morgunov B.A., Chashchin V.P., Gudkov A.B., Chashchin M.V., Popova O.N., Nikanov A.N., Thomassen Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://zniso.fcgie.ru/jour/article/view/967
Introduction: Motor transport with internal combustion engines powered by diesel fuel and gasoline is one of the main sources of ambient air pollution since its emissions pose an urgent medical and environmental challenge.The objective of the study was to identify priority types of pollutants from emissions of motor vehicles powered by internal combustion engines based on the results of a systematic review in order to substantiate the main preventive strategy to mitigate the associated public health adverse effects.Methods: We did keyword search for relevant publications in several electronic databases, such as the Russian Science Citation Index, CyberLeninka, Scopus, and WoS. Research papers published in 2000–2021 were selected for the analysis. Out of 103 topical full-text publications, 59 works met the criteria for inclusion in the systematic review.Results: We observed that atmospheric emissions of internal combustion engines represent a complex agglomeration of gases, vapors, and particulate matter. The chemicals present in the emissions impair the oxygen transport function by inhibiting cellular respiration, cause irritation of mucous membranes, have mutagenic and carcinogenic effects, contribute to the occurrence of acid rains and to global warming. The biological effect of airborne particles largely depends on their size. It has been established that an increase in the number of airborne particles with an aerodynamic diameter less than 10 μm is associated with the risk of endothelial inflammation, thrombosis, increased cell permeability, and DNA methylation. It has been also demonstrated that a 5 µg/m3 increment in ambient concentrations of fine particles (< 2.5 μm) causes a 7 % increase in the mortality rate. At the same time, PM2.5 exposure-related risks of excess deaths from cardiovascular diseases are twice as high as those posed by exposure to PM10.Conclusions: Diesel and gasoline engine exhausts are a significant risk factor for human health. An effective preventive strategy should be aimed at replacing heavy hydrocarbon motor fuels by compressed gas using hydrogen cells and electric motors.
Введение. Автомобильный транспорт с дизельными и бензиновыми двигателями внутреннего сгорания (ДВС), выбросы которых представляют актуальную медико-экологическую проблему, является одним из основных источников загрязнения атмосферного воздуха.Целью исследования является выявление по результатам систематического обзора приоритетных видов загрязняющих веществ в выбросах автотранспорта с двигателями внутреннего сгорания с целью определения общей стратегии по снижению связанных с ними неблагоприятных последствий для здоровья населения.Методы. Поиск релевантных публикаций осуществлялся по ключевым словам, размещенным в базах данных и информационных системах, в том числе таких электронных базах данных, как РИНЦ, КиберЛенинка, Scopus, WoS. Для анализа были выбраны научные работы, опубликованные за период 2000–2021 гг. По результатам целевого поиска выявлено 103 полнотекстовые публикации, из них 59 полностью соответствуют критериям включения в систематический обзор.Результаты. Показано, что выбросы ДВС в атмосферу представляют собой сложную агломерацию газов, паров и взвешенных частиц. Химические вещества, присутствующие в выбросах, нарушают кислородтранспортную функцию, подавляя тканевое дыхание, вызывают раздражение слизистых оболочек, проявляют мутагенное и канцерогенное действие, способствуют возникновению кислотных дождей и глобальному потеплению. Биологическое действие взвешенных в воздухе частиц во многом зависит от их размера. Установлено, что увеличение количества частиц с аэродинамическим диаметром менее 10 мкм в воздухе связано с риском воспаления эндотелия, тромбоза, повышения проницаемости клеток, метилирования ДНК. Показано, что увеличение концентрации в воздухе частиц размером менее 2,5 мкм на каждые 5 мкг/м3 приводит к увеличению смертности на 7 %. При этом риски дополнительных случаев смерти от сердечно-сосудистых заболеваний при воздействии этих частиц в 2 раза выше по сравнению с частицами большего размера (PM10).Заключение. Выбросы автомобилей с дизельными и бензиновыми двигателями внутреннего сгорания являются значительным фактором риска для здоровья населения. Эффективная стратегия предотвращения их неблагоприятного воздействия должна быть направлена на замену тяжелых углеводородных моторных топлив сжатым газом с использованием водородных элементов и электродвигателей для транспортных средств.
автомобильный транспортвыбросы двигателей внутреннего сгораниязагрязнение воздухариск для здоровьяroad transportinternal combustion engine exhaustsair pollutionhealth riskСтатья подготовлена при поддержке Министерства науки и высшего образования Российской Федерации в рамках исследовательского гранта (ID гранта: 075-15-2020-978).The article was prepared within the framework of a research grant funded by the Ministry of Science and Higher Education of the Russian Federation (Grant ID: 075-15-2020-978).
The use of mineral fuel in internal combustion engines (ICE) of motor vehicles is the largest source of air pollution [1–3], which is a major public health concern worldwide [4–8]. Emissions from road transport account for at least 60 % of the total air pollution in the United States, Germany and France. Annual combustion of 31.2 billion tons of motor fuel in 106 billion tons of atmospheric oxygen generates 137.2 billion tons of additional waste [9]. Cars and trucks contribute major percent to road transport exhaust [10].
Exhaust fumes contain from 200 to 300 pollutants and their compounds [11][12]. At the same time, the term “exhaust fumes” cannot be considered completely correct, since engine emissions include both gases (gas phase) and fine particulate matter (particulate phase).
The objective of the study was to identify, based on the results of a systematic review, priority types of pollutants from emissions of motor vehicles powered by internal combustion engines in order to substantiate the main preventive strategy to mitigate the associated public health adverse effects
Methods. We searched for publications on emissions from internal combustion engine vehicles in several electronic databases, such as the Russian Science Citation Index, CyberLeninka, Scopus, and WoS using the following keywords and phrases: “road transport”, “internal combustion engines”, “air pollution”, and “health risks”.
The main criteria for including the results of published works into the systematic analysis were:
Research papers published in 2000–2021 were selected for the analysis, and 59 of 103 topical fulltext publications met the criteria of inclusion in the systematic review.
Results. Emissions produced by internal combustion engines powered by hydrocarbon fuels, such as gasoline, diesel, and fuel oil, are a complex mixture of gas-, vapor-, and fine particulate-phase materials. Their major pollutants include carbon dioxide (CO2), carbon monoxide (CO), nitrogen oxides (NOx), hydrocarbons, fine, ultrafine and nano-sized carbonaceous particulate matter (PM), hydrofluorocarbon-134a (HFC-134a), methane (CH4), nitrous oxide (N2O), ozone (O3), and other chemicals classified as “hazardous air pollutants” [13][14].
To date, characteristics of the major types of airborne contaminants coming from internal combustion engines utilizing fuels produced from heavy hydrocarbon raw materials, products of their transformation in atmospheric air, and types of exposure-related adverse human health effects have been established (see Table).
Table. Components of internal combustion engine emissions and their potential adverse human health effects
Таблица. Эмиссионные компоненты двигателей внутреннего сгорания и их возможные вредные эффекты на организм человека
Judging by the results of recent national and international research, special attention is paid to aerosol particulate matter (PM) when analyzing ICE emissions [15][16]. This is due to the fact that numerous studies have proven a negative impact of fine particle on human health, including the incidence [17–20] and mortality [21][22] from diseases of cardiovascular and respiratory systems. Contained fine particles include nickel, vanadium, sulfates, nitrates, and silicon compounds [23]. The proportion of nickel in particulate matter is a marker of air pollution with ICE vehicle emissions [24]. Fine PM consists of various airborne objects, such as dust, dirt, soot, smoke, and liquid droplets [25][26].
It has been demonstrated that human health effects of fine particles are largely determined by their aerodynamic diameter: particles smaller than 10 micrometers (PM10) are able to pass through the bronchial tree and accumulate in the lung tissue; particles smaller than 2.5 μm (PM2.5) reach the alveoli, and those smaller than 0.1 μm (PM0.1) penetrate the blood flow [27–30].
Suspended particles smaller than 10 µm (PM10) have no safe exposure threshold and are considered priority pollutants in terms of public health impact [31]. The proportion of such particles in ambient air of industrial cities ranges from 30 % to 60 % of TSP [32–36] and is mainly attributed to motor vehicle exhausts, tire and road surface wear, contribution of which to emissions ranges from 30 % to 40 % [37]. Transport-related PM2.5 was found to induce more pronounced systemic inflammation than industrial particles of similar composition [38]. Diesel exhaust is the major source of PM10 and PM2.5 [39]. Up to 90 % of solid particles emitted by internal combustion engines powered by hydrocarbon fuels are fine particles (PM2.5). They are usually used as the most informative marker of transport-related air pollution intensity produced by internal combustion engines, including for assessing the benefits of using various types of motor fuel, for example, liquefied natural gas compared to diesel or gasoline as regards their potential adverse effects on public health [40].
The analysis of big data arrays, cohort studies and meta-analysis has shown correlations between PM10 air pollution and stoke hospitalizations [41–43] as well as PM2.5 air levels and the risk of stroke [44] and deaths from ischemic and hemorrhagic stroke [45]. It has also revealed that nanoparticles are able to penetrate alveoli [46] and cause inflammation in cellular endothelium [47], which induces increased cell permeability [48] and DNA methylation [49]; arterial fibrillation [50] and autonomous disturbances [8] are observed, leading to higher mortality rates in the population. Thus, every 5 μg/m3 of increment of ambient PM2.5 level accounts for a 7 % increase in the mortality rate [51]. At the same time, the risks of additional deaths from cardiovascular diseases related to PM2.5 exposure are twice as high as those associated with РМ10 [28].
It is assumed that ultrafine fractions of carbonaceous particulate matter pose the most serious health challenge compared to other ICE pollutants [52–55]. Human exposure to the latter usually occurs in the form of a three-phase system: “gas – liquid – particulate matter”, where liquid and partially gaseous phases are absorbed by solid carbon particles, resulting in the phenomenon of deep penetration of liquid and gaseous pollutants to alveoli, the most vulnerable part of the respiratory system [56–58]. It should be noted that ICE pollutants, when not carried in the absorbed form by carbon ultrafine particles, are almost completely absorbed in the upper respiratory tract.
Fine and nano-sized fractions of carbon particles are capable of agglomeration and agglutination, which significantly increases their sorption potential (Figure).
Figure. Agglomeration of airborne carbon and silicon nanoparticles in the vicinity of open-pit mines in Kola Peninsula [59]
Рисунок. Агломерационный комплекс витающих в воздухе наночастиц углерода и кремния в районе размещения открытых карьеров горнодобывающих предприятий Кольского региона [59]
Due to certain biological inertness, elemental carbon particles that have reached the alveoli are capable of accumulation in pulmonary tissue, thus increasing the risk of diseases in the etiology of which carbon black plays an important role as age and duration of employment increase.
Thus, both gaseous and especially particulate phases of emissions from internal combustion engine vehicles are significant public health risk factors.
Conclusions. Gaseous and aerosol air pollution attributed to motor vehicles with internal combustion engines is one of the most important risk factors for non-communicable diseases in the population. The gaseous phase of exhaust fumes mainly affects the respiratory system causing mucous membrane irritation and gas exchange disturbances. Certain gaseous emission components have potential or proven mutagenic and carcinogenic properties and suppress immunity. In addition, gas-phase components of vehicle emissions contribute to acid rains and global warming. Health effects of particulate matter emitted by internal combustion engines are determined by the aerodynamic diameter of particles that can accumulate in pulmonary tissue (PM10), reach the alveoli (PM2.5), and penetrate into the blood flow (PM0.1). Airborne particles affect not only lungs, but also the cardiovascular system and increase risks of death from ischemic and hemorrhagic strokes.
ReferencesМонгуш А., Монгуш С. Ч. Влияние транспортного средства на окружающую среду // Техника и технология транспорта. 2021. № 4 (23). Доступно по: http://transport-kgasu.ru/files/N23-24ET421.pdf. Ссылка активна на 17.11.2021.Mongush A, Mongush SCh. Impact of vehicle for the environment. Tekhnika i Tekhnologiya Transporta. 2021;(4(23)):24. (In Russ.) Accessed May 16, 2022. http://transport-kgasu.ru/files/N23-24ET421.pdfМусихина С.А., Степанова В.Г., Мусихина Е.А. Санитарно-гигиеническая характеристика атмосферного воздуха основных транспортных магистралей промышленного города. Здоровье населения и среда обитания. 2021. № 1(334). С. 49–53. doi: 10.35627/2219-5238/2021-334-1-49-53Musikhina SA, Stepanova VG, Musikhina EA. Sanitary and hygienic characteristics of the ambient air of major roads in an industrial city. Zdorov’e Naseleniya i Sreda Obitaniya. 2021;(1(334)):49-53. (In Russ.) doi: 10.35627/2219-5238/2021-334-1-49-53Акулов К.А. Воеводин Е.С. Автомобилизация и ее воздействие на экологию Красноярского края // Техника и технология транспорта. 2021. № 2(21). Доступно по: http://transport-kgasu.ru/files/N21-24IT221.pdf. Ссылка активна на 16.05.2022.Akulov KA, Voevodin ES. Motorization and its impact on the ecology of the Krasnoyarsk Territory. Tekhnika i Tekhnologiya Transporta. 2021;(2(21)):24. (In Russ.) Accessed May 16, 2022. http://transport-kgasu.ru/files/N21-24IT221.pdfРакитский В.Н., Авалиани С.Л., Новиков С.М., Шашина Т.А., Додина Н.С., Кислицин В.А. Анализ риска здоровью при воздействии атмосферных загрязнений как составная часть стратегии уменьшения глобальной эпидемии неинфекционных заболеваний // Анализ риска здоровью. 2019. № 4. С. 30–36. doi: 10.21668/health.risk/2019.4.03Rakitskii VN, Avaliani SL, Novikov SM, Shashina TA, Dodina NS, Kislitsin VA. Health risk analysis related to exposure to ambuent air contamination as a component in the strategy aimed at reducing global non-infectious epidemics. Health Risk Analysis. 2019;(4):30-35. doi: 10.21668/health.risk/2019.4.03.engBrook RD, Rajagopalan S, Pope CA 3rd, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-2378. doi: 10.1161/CIR.0b013e3181dbece1Brook RD, Rajagopalan S, Pope CA 3rd, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-2378. doi: 10.1161/CIR.0b013e3181dbece1Гироу М., Рейс Ж. Инсульт и загрязнение воздуха как общемировая проблема здравоохранения // Анализ риска здоровью. 2020. № 3. С. 19–22. doi: 10.21668/health.risk/2020.3.02Giroud M, Reis J. Stroke and air pollution. A worldwide public health problem. Health Risk Analysis. 2020;(3):19-21. doi: 10.21668/health.risk/2020.3.02.engSamarasekera U. New EU health programme comes into force. Lancet. 2021;397(10281):1252-1253. doi: 10.1016/S0140-6736(21)00772-8Samarasekera U. New EU health programme comes into force. Lancet. 2021;397(10281):1252-1253. doi: 10.1016/S0140-6736(21)00772-8Graber M, Mohr S, Baptiste L, et al. Air pollution and stroke. A new modifiable risk factor is in the air. Rev Neurol (Paris). 2019;175(10):619-624. doi: 10.1016/j.neurol.2019.03.003Graber M, Mohr S, Baptiste L, et al. Air pollution and stroke. A new modifiable risk factor is in the air. Rev Neurol (Paris). 2019;175(10):619-624. doi: 10.1016/j.neurol.2019.03.003RSW. Transport as one of the main causes for environmental pollution. September 30, 2019. Accessed May 16, 2022. https://rsw-systems.com/news/environmental-pollutionRSW. Transport as one of the main causes for environmental pollution. September 30, 2019. Accessed May 16, 2022. https://rsw-systems.com/news/environmental-pollutionAllen MR, Frame DJ, Huntingford C, et al. Warming caused by cumulative carbon emissions towards the trillionth tonne. Nature. 2009;458(7242):1163-1166. doi: 10.1038/nature08019Allen MR, Frame DJ, Huntingford C, et al. Warming caused by cumulative carbon emissions towards the trillionth tonne. Nature. 2009;458(7242):1163-1166. doi: 10.1038/nature08019Reif K, ed. Dieselmotor-Management im Überblick: Einschließlich Abgastechnik. 2nd ed. Springer Vieweg Wiesbaden; 2014. doi: 10.1007/978-3-658-06555-3Reif K, ed. Dieselmotor-Management im Überblick: Einschließlich Abgastechnik. 2nd ed. Springer Vieweg Wiesbaden; 2014. doi: 10.1007/978-3-658-06555-3U.S. EPA. Health Assessment Document for Diesel Engine Exhaust (Final 2002). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, EPA/600/8-90/057F, 2002. Accessed May 16, 2022. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=29060U.S. EPA. Health Assessment Document for Diesel Engine Exhaust (Final 2002). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, EPA/600/8-90/057F, 2002. Accessed May 16, 2022. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=29060Wallington TJ, Sullivan JL, Hurley MD. Emissions of CO2, CO, NOx, HC, PM, HFC-134a, N2O and CH4 from the global light duty vehicle fleet. Meteorol Z. 2008;17(2):109-116. doi: 10.1127/0941-2948/2008/0275Wallington TJ, Sullivan JL, Hurley MD. Emissions of CO2, CO, NOx, HC, PM, HFC-134a, N2O and CH4 from the global light duty vehicle fleet. Meteorol Z. 2008;17(2):109-116. doi: 10.1127/0941-2948/2008/0275Maryland Department of the Environment. Diesel emissions health and environmental effects. Accessed May 15, 2022. https://mde.maryland.gov/programs/air/mobilesources/pages/dieselhealthandenvironmentaleffects.aspxMaryland Department of the Environment. Diesel emissions health and environmental effects. Accessed May 15, 2022. https://mde.maryland.gov/programs/air/mobilesources/pages/dieselhealthandenvironmentaleffects.aspxJiang S, Bo L, Gong C, et al. Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. Int Arch Occup Environ Health. 2016;89(6):911-921. doi: 10.1007/s00420-016-1129-3Jiang S, Bo L, Gong C, et al. Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. Int Arch Occup Environ Health. 2016;89(6):911-921. doi: 10.1007/s00420-016-1129-3Вильк М.Ф., Сачкова О.С., Леванчук Л.А., Латынин Е.О. Особенности оценки профессионального риска здоровью работников, контактирующих с аэрозолями мелкодисперсных пылевых частиц // Анализ риска здоровью. 2020. № 4. С. 106–112. doi: 10.21668/health.risk/2020.4.12Vil’k MF, Sachkova OS, Levanchuk LA, Latynin EO. Peculiarities in assessing occupational health risks for workers who are in contact with aerosols containing fine-dispersed dust particles. Health Risk Analysis, 2020;(4):107-112. doi: 10.21668/health.risk/2020.4.12.engPolichetti G, Cocco S, Spinali A, Trimarco V, Nunziata A. Effects of particulate matter (PM( 10 ), PM( 2.5 ) and PM(1)) on the cardiovascular system. Toxicology. 2009;261(1-2):1-8. doi: 10.1016/j.tox.2009.04.035Polichetti G, Cocco S, Spinali A, Trimarco V, Nunziata A. Effects of particulate matter (PM( 10 ), PM( 2.5 ) and PM(1)) on the cardiovascular system. Toxicology. 2009;261(1-2):1-8. doi: 10.1016/j.tox.2009.04.035Künzli N, Kaiser R, Medina S, et al. Public-health impact of outdoor and traffic-related air pollution: a European assessment. Lancet. 2000;356(9232):795-801. doi: 10.1016/S0140-6736(00)02653-2Künzli N, Kaiser R, Medina S, et al. Public-health impact of outdoor and traffic-related air pollution: a European assessment. Lancet. 2000;356(9232):795-801. doi: 10.1016/S0140-6736(00)02653-2Wang W, Yu T, Ciren P, Jiang P. Assessment of human health impact from PM 10 exposure in China based on satellite observations. J Appl Remote Sens. 2015;9(1):096027. doi: 10.1117/1.JRS.9.096027Wang W, Yu T, Ciren P, Jiang P. Assessment of human health impact from PM 10 exposure in China based on satellite observations. J Appl Remote Sens. 2015;9(1):096027. doi: 10.1117/1.JRS.9.096027Калаева С.З., Чистяков Я.В., Муратова К.М., Чеботарев П.В. Влияние мелкодисперсной пыли на биосферу и человека // Известия Тульского государственного университета. Науки о Земле. 2016. № 3. С. 40–63.Kalaeva SZk, Chistyakov YV, Muratova KM, Chebotarev PV. Influencing fine-dispersed dust upon biosphere and human. Izvestiya Tul’skogo Gosudarstvennogo Universiteta. Nauki o Zemle. 2016;(3):40-63. (In Russ.)Berico M, Luciani A, Formignani M. Atmospheric aerosol in an urban area – measurements of TSP and PM 10 standards and pulmonary deposition assessments. Atmos Environ. 1997;31(21):3659-3665. doi: 10.1016/S1352-2310(97)00204-5Berico M, Luciani A, Formignani M. Atmospheric aerosol in an urban area – measurements of TSP and PM 10 standards and pulmonary deposition assessments. Atmos Environ. 1997;31(21):3659-3665. doi: 10.1016/S1352-2310(97)00204-5Powe NA, Willis KG. Mortality and morbidity benefits of air pollution (SO2 and PM10) absorption attributable to woodland in Britain. J Environ Manage. 2004;70(2):119-128. doi: 10.1016/j.jenvman.2003.11.003Powe NA, Willis KG. Mortality and morbidity benefits of air pollution (SO2 and PM10) absorption attributable to woodland in Britain. J Environ Manage. 2004;70(2):119-128. doi: 10.1016/j.jenvman.2003.11.003Health Effects of Particulate Matter. Policy Implications for Countries in Eastern Europe, Caucasus and Central Asia. World Health Organization; 2013. Accessed May 16, 2022 https://www.euro.who.int/__data/assets/pdf_file/0006/189051/Health-effects-of-particulate-matter-final-Eng.pdfHealth Effects of Particulate Matter. Policy Implications for Countries in Eastern Europe, Caucasus and Central Asia. World Health Organization; 2013. Accessed May 16, 2022 https://www.euro.who.int/__data/assets/pdf_file/0006/189051/Health-effects-of-particulate-matter-final-Eng.pdfAndronova AV, Iordanskii MA, Trefilova AV, et al. Comparative analysis of pollution of the surface atmospheric layer in such megalopolises as Moscow and Beijin. Izvestiya. Atmospheric and Oceanic Physics. 2011;47(7):819-827. doi: 10.1134/S0001433811070024Andronova AV, Iordanskii MA, Trefilova AV, et al. Comparative analysis of pollution of the surface atmospheric layer in such megalopolises as Moscow and Beijin. Izvestiya. Atmospheric and Oceanic Physics. 2011;47(7):819-827. doi: 10.1134/S0001433811070024Чащин В.П., Сюрин С.А., Гудков А.Б., Попова О.Н., Воронин А.Ю. Воздействие промышленных загрязнений атмосферного воздуха на организм работников, выполняющих трудовые операции на открытом воздухе в условиях холода // Медицина труда и промышленная экология. 2014. № 9. С. 20–26.Tchashin VP, Siurin SA, Gudkov AB, Popova ON, Voronin AYu. Influence of industrial pollution of ambient air on health of workers engaged into open air activities in cold conditions. Meditsina Truda i Promyshlennaya Ekologiya. 2014;(9):20-26. (In Russ.)Стреляева А.Б., Лаврентьева Л., Лупиногин В.В., Гвоздков И.А. Исследования запылённости в жилой зоне, расположенной вблизи промышленных предприятий частицами РМ 10 и РМ 2,5 // Инженерный вестник Дона. 2017. № 2(45). С. 164. http://ivdon.ru/uploads/article/pdf/IVD_164_Strelyaeva_Lavrentyeva.pdf_079280bd44.pdfStrelyaeva AB, Lavrentyeva LM, Lupinogin VV, Gvozdkov IA. [Studies of РМ 10 and РМ 2.5 air pollution in a residential area adjacent to industrial enterprises.] Inzhenernyy Vestnik Dona. 2017;(2(45)):164. (In Russ.) Accessed May 16, 2022. http://ivdon.ru/uploads/article/pdf/IVD_164_Strelyaeva_Lavrentyeva.pdf_079280bd44.pdfРевич Б.А. Мелкодисперсные взвешенные частицы в атмосферном воздухе и их воздействие на здоровье жителей мегаполисов // Проблемы экологического мониторинга и моделирования экосистем. 2018. Т. 29. № 3. С. 53–78. doi: 10.21513/0207-2564-2018-3-53-78Revich BA. Fine suspended particulates in ambient air and their health effects in megalopolises. Problemy Ekologicheskogo Monitoringa i Modelirovaniya Ekosistem. 2018;29(3):53-78. (In Russ.) doi: 10.21513/0207-2564-2018-3-53-78Health and Environmental Effects of Particulate Matter (PM). U.S. Environmental Protection Agency. Accessed May 16, 2022. https://www.epa.gov/pm-pollution/health-and-environmental-effects-particulate-matter-pmHealth and Environmental Effects of Particulate Matter (PM). U.S. Environmental Protection Agency. Accessed May 16, 2022. https://www.epa.gov/pm-pollution/health-and-environmental-effects-particulate-matter-pmЧижова В.С. Оценка влияния различных факторов на интенсивность выделения аэрозольных частиц менее 10 мкм на улично-дорожной сети // Вестник Московского автомобильно-дорожного государственного технического университета (МАДИ). 2014. № 2 (37). С. 106–110.Chizhova VS. Аssessment of influence of various factors on the intensity of the allocation of aerosol particles less than 10 micrometer on the street road network. Vestnik Moskovskogo Avtomobil’no-Dorozhnogo Gosudarstvennogo Tekhnicheskogo Universiteta (MADI). 2014;(2(37)):106-110. (In Russ.)Yi O, Hong YC, Kim H. Seasonal effect of PM(10) concentrations on mortality and morbidity in Seoul, Korea: a temperature-matched case-crossover analysis. Environ Res. 2010;110(1):89-95. doi: 10.1016/j.envres.2009.09.009Yi O, Hong YC, Kim H. Seasonal effect of PM(10) concentrations on mortality and morbidity in Seoul, Korea: a temperature-matched case-crossover analysis. Environ Res. 2010;110(1):89-95. doi: 10.1016/j.envres.2009.09.009Просвирякова И.А., Шевчук Л.М. Гигиеническая оценка содержания твердых частиц РМ 10 и РМ 2.5 в атмосферном воздухе и риска для здоровья жителей в зоне влияния выбросов стационарных источников промышленных предприятий // Анализ риска здоровью. 2018. № 2. С. 14–22. doi: 10.21668/health.risk/2018.2.02Prosviryakova IA, Shevchuk LM. Hygienic assessment of PM 10 and PM 2.5 contents in the atmosphere and population health risk in zones influenced by emissions from stationary sources located at industrial enterprises. Health Risk Analysis. 2018;(2):14-22. doi: 10.21668/health.risk/2018.2.02.engLim JM, Lee JH, Moon JH, Chung YS, Kim KH. Airborne PM 10 and metals from multifarious sources in an industrial complex area. Atmos Res. 2010;96(1):53-64. doi: 10.1016/j.atmosres.2009.11.013Lim JM, Lee JH, Moon JH, Chung YS, Kim KH. Airborne PM 10 and metals from multifarious sources in an industrial complex area. Atmos Res. 2010;96(1):53-64. doi: 10.1016/j.atmosres.2009.11.013Zhang XX, Sharratt B, Chen X, et al. Dust deposition and ambient PM 10 concentration in northwest China: spatial and temporal variability. Atmos Chem Phys. 2017;17(3):1699-1711. doi: 10.5194/acp-17-1699-2017Zhang XX, Sharratt B, Chen X, et al. Dust deposition and ambient PM 10 concentration in northwest China:spatial and temporal variability. Atmos Chem Phys. 2017;17(3):1699-1711. doi: 10.5194/acp-17-1699-2017Otorepec S, Podbevšek N, Jereb B. PM 10 risks in countries of European Union. Vestnik SamGUPS. 2014;3(25):9-17. (In Russ.)Otorepec S, Podbevšek N, Jereb B. PM 10 risks in countries of European Union. Vestnik SamGUPS. 2014;3(25):9-17. (In Russ.)Soriano A, Pallarés S, Vicente AB, Sanfeliu T, Jordán MM. Assessment of the main sources of PM 10 in an industrialized area situated in a Mediterranean Basin. Fresenius Environ Bull. 2011;20(9):2379-2390.Soriano A, Pallarés S, Vicente AB, Sanfeliu T, Jordán MM. Assessment of the main sources of PM 10 in an industrialized area situated in a Mediterranean Basin. Fresenius Environ Bull. 2011;20(9):2379-2390.Bernardoni V, Vecchi R, Valli G, Piazzalunga A, Fermo P. PM 10 source apportionment in Milan (Italy) using time-resolved data. Sci Total Environ. 2011;409(22):4788-4795. doi: 10.1016/j.scitotenv.2011.07.048Bernardoni V, Vecchi R, Valli G, Piazzalunga A, Fermo P. PM 10 source apportionment in Milan (Italy) using time-resolved data. Sci Total Environ. 2011;409(22):4788-4795. doi: 10.1016/j.scitotenv.2011.07.048Cozzi L, et al. World Energy Outlook Special Report 2016: Energy and Air Pollution. Paris, France: International Energy Agency; 2016. Accessed May 16, 2022. http://pure.iiasa.ac.at/id/eprint/13467/1/WorldEnergyOutlookSpecialReport2016EnergyandAirPollution.pdfCozzi L, et al. World Energy Outlook Special Report 2016: Energy and Air Pollution. Paris, France: International Energy Agency; 2016. Accessed May 16, 2022. http://pure.iiasa.ac.at/id/eprint/13467/1/WorldEnergyOutlookSpecialReport2016EnergyandAirPollution.pdfHennig F, Fuks K, Moebus S, et al. Association between source-specific particulate matter air pollution and hs-CRP: Local traffic and industrial emissions. Environ Health Perspect. 2014;122(7):703-710. doi: 10.1289/ehp.1307081Hennig F, Fuks K, Moebus S, et al. Association between source-specific particulate matter air pollution and hs-CRP: Local traffic and industrial emissions. Environ Health Perspect. 2014;122(7):703-710. doi: 10.1289/ehp.1307081Азаров В.Н., Горшков Е.В., Недре А.Ю., Воробьев В.И. О некоторых мерах по снижению выбросов в атмосферный воздух твердых частиц (РМ 10 и РМ2,5 ) на основе опыта Нидерландов // Вестник Волгоградского государственного архитектурно-строительного университета. Серия: Строительство и архитектура. 2011. № 25(44). С. 407-410.Azarov VN, Gorshkova YeV, Nedre AYu, Vorobev VI. About methods to reduce emissions of particulate matters (PM 10 and PM 2,5 ) empirically Netherlands. Vestnik Volgogradskogo Gosudarstvennogo Arkhitekturno-Stroitel’nogo Universiteta. Seriya: Stroitel’stvo i Arkhitektura. 2011;(25(44)):407-410. (In Russ.)Teixeira ACR, Borges RR, Machado PG, Mouette D, Ribeiro FND. PM emissions from heavy-duty trucks and their impacts on human health. Atmos Environ. 2020;241:117814. doi: 10.1016/j.atmosenv.2020.117814Teixeira ACR, Borges RR, Machado PG, Mouette D, Ribeiro FND. PM emissions from heavy-duty trucks and their impacts on human health. Atmos Environ. 2020;241:117814. doi: 10.1016/j.atmosenv.2020.117814Kulick ER, Wellenius GA, Boehme AK, Sacco RL, Elkind MS. Residential proximity to major roadways and risk of incident ischemic stroke in NOMAS (The Northern Manhattan Study). Stroke. 2018;49(4):835-841. doi: 10.1161/STROKEAHA.117.019580Kulick ER, Wellenius GA, Boehme AK, Sacco RL, Elkind MS. Residential proximity to major roadways and risk of incident ischemic stroke in NOMAS (The Northern Manhattan Study). Stroke. 2018;49(4):835-841. doi: 10.1161/STROKEAHA.117.019580Ljungman PL, Mittleman MA. Ambient air pollution and stroke. Stroke. 2014;45(12):3734-3741. doi: 10.1161/STROKEAHA.114.003130Ljungman PL, Mittleman MA. Ambient air pollution and stroke. Stroke. 2014;45(12):3734-3741. doi: 10.1161/STROKEAHA.114.003130Wang M, Beelen R, Stafoggia M, et al. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int. 2014;66:97-106. doi: 10.1016/j.envint.2014.01.026Wang M, Beelen R, Stafoggia M, et al. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int. 2014;66:97-106. doi: 10.1016/j.envint.2014.01.026Schraufnagel DE. The health effects of ultrafine particles. Exp Mol Med. 2020;52(3):311-317. doi: 10.1038/s12276-020-0403-3Schraufnagel DE. The health effects of ultrafine particles. Exp Mol Med. 2020;52(3):311-317. doi: 10.1038/s12276-020-0403-3Zhang R, Liu G, Jiang Y, et al. Acute effects of particulate air pollution on ischemic stroke and hemorrhagic stroke mortality. Front Neurol. 2018;9:827. doi: 10.3389/fneur.2018.00827Zhang R, Liu G, Jiang Y, et al. Acute effects of particulate air pollution on ischemic stroke and hemorrhagic stroke mortality. Front Neurol. 2018;9:827. doi: 10.3389/fneur.2018.00827Oberdörster G, Sharp Z, Atudorei V, et al. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A. 2002;65(20):1531-1543. doi: 10.1080/00984100290071658Oberdörster G, Sharp Z, Atudorei V, et al. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A. 2002;65(20):1531-1543. doi: 10.1080/00984100290071658Aung HH, Lame MW, Gohil K, et al. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics. 2011;43(15):917-929. doi: 10.1152/physiolgenomics.00051.2011Aung HH, Lame MW, Gohil K, et al. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics. 2011;43(15):917-929. doi: 10.1152/physiolgenomics.00051.2011Chao MW, Kozlosky J, Po IP, et al. Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin. Toxicology. 2011;279(1-3):73-84. doi: 10.1016/j.tox.2010.09.011Chao MW, Kozlosky J, Po IP, et al. Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin. Toxicology. 2011;279(1-3):73-84. doi: 10.1016/j.tox.2010.09.011Fraineau S, Palii CG, Allan DS, Brand M. Epigenetic regulation of endothelial-cell-mediated vascular repair. FEBS J. 2015;282(9):1605-1629. doi: 10.1111/febs.13183Fraineau S, Palii CG, Allan DS, Brand M. Epigenetic regulation of endothelial-cell-mediated vascular repair. FEBS J. 2015;282(9):1605-1629. doi: 10.1111/febs.13183Chung JW, Bang OY, Ahn K, et al. Air pollution is associated with ischemic stroke via cardiogenic embolism. Stroke. 2017;48(1):17-23. doi: 10.1161/STROKEAHA.116.015428Chung JW, Bang OY, Ahn K, et al. Air pollution is associated with ischemic stroke via cardiogenic embolism. Stroke. 2017;48(1):17-23. doi: 10.1161/STROKEAHA.116.015428Beelen R, Raaschou-Nielsen O, Stafoggia M, et al. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet. 2014;383(9919):785-795. doi: 10.1016/S0140-6736(13)62158-3Beelen R, Raaschou-Nielsen O, Stafoggia M, et al. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet. 2014;383(9919):785-795. doi: 10.1016/S0140-6736(13)62158-3WHO Expert Meeting: Methods and Tools for Assessing the Health Risks of Air Pollution at Local, National and International Level, Bonn, Germany, May 12–13, 2014. World Health Organization; 2014. Accessed May 16, 2022. https://www.euro.who.int/__data/assets/pdf_file/0010/263629/WHO-Expert-Meeting-Methods-and-tools-for-assessing-the-health-risks-of-air-pollution-at-local,-national-and-international-level.pdfWHO Expert Meeting: Methods and Tools for Assessing the Health Risks of Air Pollution at Local, National and International Level, Bonn, Germany, May 12–13, 2014. World Health Organization; 2014. Accessed May 16, 2022. https://www.euro.who.int/__data/assets/pdf_file/0010/263629/WHO-Expert-Meeting-Methods-and-tools-for-assessing-the-health-risks-of-air-pollution-at-local,-national-and-international-level.pdfHealth Risks of Air Pollution in Europe – HRAPIE Project. Recommendations for concentration–response functions for cost–benefit analysis of particulate matter, ozone and nitrogen dioxide. World Health Organization; 2013. Accessed May 16, 2022. https://www.euro.who.int/__data/assets/pdf_file/0006/238956/Health_risks_air_pollution_HRAPIE_project.pdfHealth Risks of Air Pollution in Europe – HRAPIE Project. Recommendations for concentration–response functions for cost–benefit analysis of particulate matter, ozone and nitrogen dioxide. World Health Organization; 2013. Accessed May 16, 2022. https://www.euro.who.int/__data/assets/pdf_file/0006/238956/Health_risks_air_pollution_HRAPIE_project.pdfПискунов И.В., Глаголева О.Ф., Голубева И.А. Альтернативные виды топлив для устойчивого развития транспортного сектора Часть 2. Водородное топливо // Транспорт на альтернативном топливе. 2021. № 5(83). С. 53–62.Piskunov IV, Glagoleva OF, Golubeva IA. Alternative fuels for sustainable development of the transport sector. Part 2. Hydrogen fuel. Transport na Al’ternativnom Toplive. 2021;(5(83)):53-62. (In Russ.)Клейн С.В., Попова Е.В. Гигиеническая оценка качества атмосферного воздуха г. Читы - приоритетной территории федерального проекта «Чистый воздух» // Здоровье населения и среда обитания. 2020. № 12(333). С. 16–22. doi: 10.35627/2219-5238/2020-333-12-16-22Kleyn SV, Popova EV. Hygienic assessment of ambient air quality in Chita, a priority area of the Federal Clean Air Project. Zdorov’e Naseleniya i Sreda Obitaniya. 2020;(12(333)):16-22. (In Russ.) doi: 10.35627/2219-5238/2020-333-12-16-22Тищенко В. П. Дисперсные системы и загрязнение атмосферы и гидросферы: [науч. ред. Л.П. Майорова]. Хабаровск: Изд-во Тихоокеан. гос. ун-та, 2017. 204 с.Tishchenko VP. [Dispersed Systems and Pollution of the Atmosphere and Hydrosphere.] Mayorova LP, ed. Khabarovsk: Pacific State University Publ.; 2017. (In Russ.)Tsuda A, Henry FS, Butler JP. Particle transport and deposition: basic physics of particle kinetics. Compr Physiol. 2013;3(4):1437-1471. doi: 10.1002/cphy.c100085Tsuda A, Henry FS, Butler JP. Particle transport and deposition: basic physics of particle kinetics. Compr Physiol. 2013;3(4):1437-1471. doi: 10.1002/cphy.c100085Landrigan PJ, Fuller R, Acosta NJR, et al. The Lancet Commission on pollution and health. Lancet. 2018;391(10119):462-512. doi: 10.1016/S0140-6736(17)32345-0Landrigan PJ, Fuller R, Acosta NJR, et al. The Lancet Commission on pollution and health. Lancet. 2018;391(10119):462-512. doi: 10.1016/S0140-6736(17)32345-0SINTEF Project. MineHealth – Sustainability of miners well-being, health and work Barents. February 4, 2013. Accessed May 16, 2022. https://www.sintef.no/en/projects/2012/sustainability-of-miners-well-being-health-and-wor/SINTEF Project. MineHealth – Sustainability of miners well-being, health and work Barents. February 4, 2013. Accessed May 16, 2022. https://www.sintef.no/en/projects/2012/sustainability-of-miners-well-being-health-and-wor/
The authors declare that there are no conflicts of interest present.