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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2219-5238/2025-33-12-17-25</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-2745</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОЦИОЛОГИЯ МЕДИЦИНЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL SOCIOLOGY</subject></subj-group></article-categories><title-group><article-title>Детерминанты инсулинорезистентности у взрослых индонезийцев, не страдающих диабетом: многомерный анализ факторов метаболизма, питания и образа жизни</article-title><trans-title-group xml:lang="en"><trans-title>Determinants of Insulin Resistance among Non-Diabetic Indonesian Adults: A Multivariable Analysis of Metabolic, Dietary, and Lifestyle Factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7515-7420</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симанджунтак</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Simanjuntak</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симанджунтак Рохани Ретнаули - магистр общественного здравоохранения, докторантура факультета общественного здравоохранения университета Дипонегоро.</p><p>Ул. Проф. Якуба Раиса, Тембаланг, Семаранг, Центральная Ява, 50275</p></bio><bio xml:lang="en"><p>Rohani Retnauli Simanjuntak - MPH, Doctoral Program of Public Health, Public Health Faculty.</p><p>Prof. Jacub Rais Street, Tembalang, Semarang, Central Java, 50275</p></bio><email xlink:type="simple">retnauli@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4845-3730</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Картини</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kartini</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Картини Апоина - доктор философии, кафедра общественного питания факультета общественного здравоохранения Университета Дипонегоро.</p><p>Ул. Проф. Якуба Раиса, Тембаланг, Семаранг, Центральная Ява, 50275</p></bio><bio xml:lang="en"><p>Apoina Kartini - PhD - Public Health Nutrition Department, Public Health Faculty.</p><p>Prof. Jacub Rais Street, Tembalang, Semarang, Central Java, 50275</p></bio><email xlink:type="simple">apoinakartini@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5177-233X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Картасурья</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kartasurya</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Картасурья Марта Ирен - доктор философии, профессор кафедры общественного питания факультета общественного здравоохранения Университета Дипонегоро.</p><p>Ул. Проф. Якуба Раиса, Тембаланг, Семаранг, Центральная Ява, 50275</p></bio><bio xml:lang="en"><p>Martha Irene Kartasurya - PhD, Professor, Public Health Nutrition Department, Public Health Faculty.</p><p>Prof. Jacub Rais Street, Tembalang, Semarang, Central Java, 50275</p></bio><email xlink:type="simple">marthakartasurya@live.undip.ac.id</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0459-4999</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нурджазули</surname></name><name name-style="western" xml:lang="en"><surname>Nurjazuli</surname><given-names>.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нурджазули - доктор философии, кафедра гигиены окружающей среды факультета общественного здравоохранения Университета Дипонегоро.</p><p>Ул. Проф. Якуба Раиса, Тембаланг, Семаранг, Центральная Ява, 50275</p></bio><bio xml:lang="en"><p>Nurjazuli, PhD - Environmental Health Department, Public Health Faculty.</p><p>Prof. Jacub Rais Street, Tembalang, Semarang, Central Java, 50275</p></bio><email xlink:type="simple">nurjazulifkmundip@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Университет Дипонегоро</institution><country>Индонезия</country></aff><aff xml:lang="en"><institution>Diponegoro University</institution><country>Indonesia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2025</year></pub-date><volume>33</volume><issue>12</issue><fpage>17</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Симанджунтак Р.Р., Картини А., Картасурья М.И., Нурджазули .., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Симанджунтак Р.Р., Картини А., Картасурья М.И., Нурджазули ..</copyright-holder><copyright-holder xml:lang="en">Simanjuntak R.R., Kartini A., Kartasurya M.I., Nurjazuli ..</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/2745">https://zniso.fcgie.ru/jour/article/view/2745</self-uri><abstract><sec><title>Введение</title><p>Введение. Инсулинорезистентность (ИР), основной предшественник диабета второго типа, встречающаяся у 44,2 % индонезийцев, оценивалась с помощью индекса триглицеридов-глюкозы (TyG) как более практичного и экономичного показателя. В Индонезии комплексные исследования зависимости между факторами метаболизма, питания и образа жизни и ИР по-прежнему проводятся редко.</p></sec><sec><title>Цель</title><p>Цель: оценить факторы метаболизма, питания и образа жизни, связанные с инсулинорезистентностью, у взрослых жителей Индонезии, не страдающих диабетом.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В нашем поперечном исследовании использовались первичные данные когортного исследования факторов риска неинфекционных заболеваний, проведенного в Богоре, Индонезия. Из 5329 респондентов 251 участник с уровнем глюкозы натощак ≥ 126 мг/дл и 463 человека с неполными данными были исключены, вследствие чего итоговая выборка составила 4615 респондентов. Инсулинорезистентность определялась по индексу TyG ≥ 8,5. Переменные с p &lt; 0,25 в критериях хи-квадрат были включены в многофакторную логистическую регрессию для выявления независимых предикторов. Были получены отношения шансов (ОШ) и 95 % доверительные интервалы (ДИ).</p></sec><sec><title>Результаты</title><p>Результаты. Многофакторный анализ выявил несколько сильных предикторов индекса TyG среди взрослых без диабета. Наибольшая корреляция с индексом триглицеридов-глюкозы была установлена для принадлежности к мужскому полу (ОШ = 3,90, 95 % ДИ: 3,15–4,82), высокого уровня общего холестерина (ОШ = 4,36, 95 % ДИ: 3,72–5,11) и низкого уровня холестерина ЛПВП (ОШ = 4,24, 95 % ДИ: 3,62–4,97). Наиболее выраженный эффект, связанный с питанием, наблюдался при частом употреблении пакетированных напитков (&gt;3 упаковок в день) (ОШ = 5,10, 95 % ДИ: 1,38–18,82). Также значимыми предикторами оказались центральное (абдоминальное) ожирение (ОШ = 2,39, 95 % ДИ: 2,01–2,84) и возраст от 40 лет (ОШ = 1,67, 95 % ДИ: 1,41–1,98).</p></sec><sec><title>Заключение</title><p>Заключение: инсулинорезистентность (индекс TyG ≥ 8,5) значимо связана с метаболизмом, питанием и модифицируемыми факторами образа жизни и может служить практическим инструментом скрининга городского населения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: Insulin resistance (IR), a major precursor of type 2 diabetes affecting 44.2 % of Indonesians, was assessed using the triglyceride–glucose (TyG) index, a more practical and economical measure. Comprehensive investigations linking IR with metabolic, dietary, and lifestyle factors remain scarce in Indonesia.</p></sec><sec><title>Objective</title><p>Objective: To assess the metabolic, dietary, and lifestyle factors associated with insulin resistance among non-diabetic adults in Indonesia.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods: This cross-sectional study used baseline data from the Non-Communicable Disease Risk Factor Cohort Study in Bogor, Indonesia. From 5,329 respondents, 251 with fasting glucose ≥126 mg/dL and 463 with incomplete data were excluded, yielding 4,615 participants. Insulin resistance was defined by a TyG index ≥8.5. Variables with p &lt; 0.25 in chi-square tests were entered into multivariable logistic regression to identify independent predictors. Odds ratios (ORs) and 95 % confidence intervals (CIs) were reported.</p></sec><sec><title>Results</title><p>Results: Multivariable analysis revealed several strong predictors of the TyG index among non-diabetic adults. Male sex (OR = 3.90, 95 % CI: 3.15–4.82), high total cholesterol (OR = 4.36, 95 % CI: 3.72–5.11), and low HDL cholesterol (OR = 4.24, 95 % CI: 3.62–4.97) demonstrated the highest associations. Frequent consumption of packaged beverages (&gt;3 packs/day) showed the greatest dietary effect (OR = 5.10, 95 % CI: 1.38–18.82). Central obesity (OR = 2.39, 95 % CI: 2.01–2.84) and age ≥ 40 years (OR = 1.67, 95 % CI: 1.41–1.98) were also significant predictors.</p></sec><sec><title>Conclusion</title><p>Conclusion: Insulin resistance (TyG index ≥ 8.5) is strongly linked to metabolic, dietary, and modifiable lifestyle factors and may serve as a practical screening tool in urban populations.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инсулинорезистентность</kwd><kwd>индекс TyG</kwd><kwd>метаболический риск</kwd><kwd>особенности питания</kwd><kwd>факторы риска</kwd><kwd>связанные с образом жизни</kwd><kwd>взрослые без диабета</kwd></kwd-group><kwd-group xml:lang="en"><kwd>insulin resistance</kwd><kwd>TyG index</kwd><kwd>metabolic risk</kwd><kwd>dietary patterns</kwd><kwd>lifestyle risk factors</kwd><kwd>non-diabetic adults</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы выражают благодарность Агентству медицинских исследований и разработок Министерства здравоохранения Индонезии за разрешение использовать данные когортного исследования факторов риска неинфекционных заболеваний</funding-statement><funding-statement xml:lang="en">The authors thank the Health Research and Development Agency, Ministry of Health of Indonesia, for permitting the use of data from the Non-Communicable Disease Risk Factor Cohort Study</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Goh LPW, Sani SA, Sabullah MK, Gansau JA. 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