<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2219-5238/2025-33-8-70-77</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-2237</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОММУНАЛЬНАЯ ГИГИЕНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMMUNAL HYGIENE</subject></subj-group></article-categories><title-group><article-title>Оценка риска для здоровья от нитратного загрязнения на территории Воронежской области</article-title><trans-title-group xml:lang="en"><trans-title>Health Risk Assessment of Nitrate Pollution in the Voronezh Region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4988-2035</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красникова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnikova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Красникова Алина Алексеевна – врач-эпидемиолог</p><p>ул. Космонавтов, д. 21, г. Воронеж, 394038</p></bio><bio xml:lang="en"><p>Alina A. Krasnikova, epidemiologist</p><p>21 Kosmonavtov Street, Voronezh, 394038</p></bio><email xlink:type="simple">a_mivi@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9228-620X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клепиков</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Klepikov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клепиков Олег Владимирович – д.биол.н., профессор, профессор кафедры геоэкологии и мониторинга окружающей среды</p><p>пл. Университетская, д. 1, г. Воронеж, 394018</p></bio><bio xml:lang="en"><p>Oleg V. Klepikov, Dr. Sci. (Biol.), Prof.; Professor, Department of Geoecology and Environmental Monitoring</p><p>1 University Square, Voronezh, 394018</p></bio><email xlink:type="simple">klepa1967@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7160-1749</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Механтьев</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Mehantyev</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Механтьев Игорь Иванович – д.м.н., доцент, доцент кафедры медицинских дисциплин</p><p>пл. Университетская, д. 1, г. Воронеж, 394018</p></bio><bio xml:lang="en"><p>Igor I. Mehantyev, Dr. Sci. (Med.), docent; Associate Professor, Department of Medical Disciplines</p><p>1 University Square, Voronezh, 394018</p></bio><email xlink:type="simple">kafgigienic@rambler.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2808-0802</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прожорина</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Prozhorina</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Прожорина Татьяна Ивановна – к.х.н., доцент кафедры геоэкологии и мониторинга окружающей среды</p><p>пл. Университетская, д. 1, г. Воронеж, 394018</p></bio><bio xml:lang="en"><p>Tatiana I. Prozhorina, Cand. Sci. (Chem.), Associate Professor, Department of Geoecology and Environmental Monitoring</p><p>1 University Square, Voronezh, 394018</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0650-5598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамчик</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamchik</surname><given-names>N. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамчик Николай Петрович – д.м.н., профессор, заведующий кафедрой эпидемиологии</p><p>ул. Студенческая, д. 10, г. Воронеж, 394036</p></bio><bio xml:lang="en"><p>Nikolay P. Mamchik, Dr. Sci. (Med.), Prof.; Head of the Department of Epidemiology</p><p>10 Studencheskaya Street, Voronezh, 394036</p></bio><email xlink:type="simple">mamchik1949@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-1153-4743</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Занина</surname><given-names>М. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Zanina</surname><given-names>M. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Занина Марина Яковлевна – к.м.н., доцент кафедры гигиены №2</p><p>Нахичеванский пер., д. 29, г. Ростов-на-Дону, 344022</p></bio><bio xml:lang="en"><p>Marina Ya. Zanina, Cand. Sci. (Med.), Associate Professor, Department of Hygiene No. 2</p><p>29 Nakhichevansky Lane, Rostov-on-Don, 344022</p></bio><email xlink:type="simple">zan72@list.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУЗ «Центр гигиены и эпидемиологии в Воронежской области»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Hygiene and Epidemiology in the Voronezh Region</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО "Воронежский государственный университет"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State Medical University named after N.N. Burdenko</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>08</month><year>2025</year></pub-date><volume>33</volume><issue>8</issue><fpage>70</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Красникова А.А., Клепиков О.В., Механтьев И.И., Прожорина Т.И., Мамчик Н.П., Занина М.Я., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Красникова А.А., Клепиков О.В., Механтьев И.И., Прожорина Т.И., Мамчик Н.П., Занина М.Я.</copyright-holder><copyright-holder xml:lang="en">Krasnikova A.A., Klepikov O.V., Mehantyev I.I., Prozhorina T.I., Mamchik N.P., Zanina M.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/2237">https://zniso.fcgie.ru/jour/article/view/2237</self-uri><abstract><sec><title>Введение</title><p>Введение. Решение задачи оценки нитратного загрязнения и связанного с ним риска для здоровья населения в современных условиях не потеряло своей актуальности в связи с частыми фактами обнаружения высоких концентраций нитратов в питьевой воде и продуктах питания.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: оценка риска воздействия на население Воронежской области нитратного загрязнения через питьевую воду и пищевые продукты.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследовании использованы данные социально-гигиенического мониторинга показателей качества воды систем централизованного хозяйственно-питьевого водоснабжения и содержания контаминантов в продовольственном сырье за период с 2012 по 2024 год в разрезе 34 административных территорий Воронежской области. Основным показателем являлся коэффициент опасности (HQ), характеризующий неканцерогенный риск.</p></sec><sec><title>Результаты</title><p>Результаты. Оценка риска воздействия на население Воронежской области нитратного загрязнения через питьевую воду и пищевые продукты показала, что большую опасность неблагоприятного воздействия на организм имеет поступление нитратов с продуктами питания, чем с питьевой водой, т. к. показатели рисков и число неблагополучных по пищевому фактору территорий выше. Более высокий риск воздействия нитратного загрязнения из числа рассматриваемых групп населения (дети, подростки, взрослые) прослеживается для детского населения: опасный уровень риска по поступлению нитратов в организм с продуктами питания выявлен на 32 из 34 административных территорий (HQ от 3,18 до 6,24), с питьевой водой в 4 районах риск характеризуется как настораживающий (HQ от 1,10 до 2,24).</p></sec><sec><title>Заключение</title><p>Заключение. Нитраты являются характерными загрязнителями для территорий Воронежской области, что требует углубленных исследований источников и причин их поступления в различные среды для предупреждения нитратного воздействия на населения. Рекомендованы профилактические мероприятия, включающие предложения по совершенствованию мониторинга и информированию населения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: The solution to the problem of assessing current nitrate pollution and the associated human health risks has not lost its relevance due to frequent detection of high concentrations of nitrates in drinking water and food.</p></sec><sec><title>Objective</title><p>Objective: To assess health risks of nitrate pollution of drinking water and food products for the population of the Voronezh Region.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: We used data on quality indicators of centralized domestic drinking water supply systems and levels of contaminants in food raw materials collected within public health surveillance for the period of 2012 to 2024 in 34 administrative territories of the Voronezh Region. The main indicator was the hazard quotient (HQ), which characterizes non-carcinogenic risk.</p></sec><sec><title>Results</title><p>Results: Health risk assessment of nitrate pollution of drinking water and food products for the population of the Voronezh Region showed that the intake of nitrates from food posed greater risks of adverse human health effects than that from drinking water, since risk indicators and the number of territories with poor food quality and safety were higher. Children were found to be at higher risk of exposure to nitrate pollution from among the population groups under consideration (children, adolescents, and adults): a dangerous level of risk posed by nitrate exposure from dietary sources was established in 32 of 34 administrative territories (HQ ranging from 3.18 to 6.24); in 4 districts, HQ of 1.10 to 2.24 indicated a possible adverse health effect of nitrates in drinking water.</p></sec><sec><title>Conclusions</title><p>Conclusions: Nitrates are typical pollutants for the territories of the Voronezh Region, which necessitates in-depth studies of the sources and causes of their entry into various environments to mitigate nitrate exposure of the population. Preventive measures are recommended, including proposals for improving monitoring and informing the public.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нитратное загрязнение</kwd><kwd>питьевая вода</kwd><kwd>пищевые продукты</kwd><kwd>оценка риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nitrate pollution</kwd><kwd>drinking water</kwd><kwd>food products</kwd><kwd>risk assessment</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">исследование выполнено за счет гранта Российского научного фонда № 25-17-00219, https://rscf.ru/project/25-17-00219/</funding-statement><funding-statement xml:lang="en">The study was supported by the Russian Science Foundation grant No. 25-17-00219, https://rscf.ru/project/25-17-00219/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gutiérrez M, Biagioni RN, Alarcón-Herrera MT, Rivas-Lucero BA. An overview of nitrate sources and operating processes in arid and semiarid aquifer systems. Sci Total Environ. 2018;624:1513-1522. doi: 10.1016/j.scitotenv.2017.12.252</mixed-citation><mixed-citation xml:lang="en">Gutiérrez M, Biagioni RN, Alarcón-Herrera MT, Rivas-Lucero BA. An overview of nitrate sources and operating processes in arid and semiarid aquifer systems. Sci Total Environ. 2018;624:1513-1522. doi: 10.1016/j.scitotenv.2017.12.252</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ward MH, Jones RR, Brender JD, et al. Drinking water nitrate and human health: An updated review. Int J Environ Res Public Health. 2018;15(7):1557. doi: 10.3390/ijerph15071557</mixed-citation><mixed-citation xml:lang="en">Ward MH, Jones RR, Brender JD, et al. Drinking water nitrate and human health: An updated review. Int J Environ Res Public Health. 2018;15(7):1557. doi: 10.3390/ijerph15071557</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Torres-Martínez JA, Mora A, Mahlknecht J, Daesslé LW, Cervantes-Avilés PA, Ledesma-Ruiz R. Estimation of nitrate pollution sources and transformations in groundwater of an intensive livestock-agricultural area (Comarca Lagunera), combining major ions, stable isotopes and MixSIAR model. Environ Pollut. 2021;269:115445. doi: 10.1016/j.envpol.2020.115445</mixed-citation><mixed-citation xml:lang="en">Torres-Martínez JA, Mora A, Mahlknecht J, Daesslé LW, Cervantes-Avilés PA, Ledesma-Ruiz R. Estimation of nitrate pollution sources and transformations in groundwater of an intensive livestock-agricultural area (Comarca Lagunera), combining major ions, stable isotopes and MixSIAR model. Environ Pollut. 2021;269:115445. doi: 10.1016/j.envpol.2020.115445</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rahman A, Mondal NC, Tiwari KK. Anthropogenic nitrate in groundwater and its health risks in the view of background concentration in a semi arid area of Rajasthan, India. Sci Rep. 2021;11(1):9279. doi: 10.1038/s41598-021-88600-1</mixed-citation><mixed-citation xml:lang="en">Rahman A, Mondal NC, Tiwari KK. Anthropogenic nitrate in groundwater and its health risks in the view of background concentration in a semi arid area of Rajasthan, India. Sci Rep. 2021;11(1):9279. doi: 10.1038/s41598-021-88600-1</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л.П., Алексеев С.В. Нитратное и аммонийное загрязнение грунтовых вод в пос. Листвянка на оз. Байкал // Известия Иркутского государственного университета. Серия: Науки о Земле. 2023. Т. 46. С. 3-15. doi: 10.26516/2073-3402.2023.46.3</mixed-citation><mixed-citation xml:lang="en">Alexeeva LP, Alexeev SV. Nitrate and ammonium contamination of groundwater in the Listvyanka settlement on Lake Baikal. Izvestiya Irkutskogo Gosudarstvennogo Universiteta. Seriya: Nauki o Zemle. 2023;46:3-15. (In Russ.) doi: 10.26516/2073-3402.2023.46.3</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мусирмонов Ж., Уринова А., Кучкарова Д. Комплексный анализ хозяйственно-бытовых сточных вод на содержание различных солей // Universum: химия и биология. 2024. № 8 (122). С. 9-17. doi: 10.32743/UniChem.2024.122.8.18048.</mixed-citation><mixed-citation xml:lang="en">Musirmonov JaJ, Urinova AA, Kuchkarova DKh, Tripath G, Farooqui A, Khujamshukurov N. Comprehensive analysis of domestic wastewater for the content of various salts. Universum: Khimiya i Biologiya. 2024;(8(122)):9-17. (In Russ.) doi: 10.32743/UniChem.2024.122.8.18048</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Харина Г.В., Алешина Л.В. Анализ качества подземных вод Свердловской области // Гигиена и санитария. 2023. Т. 102. № 3. С. 221-228. doi: 10.47470/0016-9900-2023-102-3-221-228</mixed-citation><mixed-citation xml:lang="en">Kharina GV, Alyoshina LV. Analysis of the quality of groundwater in the Sverdlovsk Region. Gigiena i Sanitariya. 2023;102(3):221-228. (In Russ.) doi: 10.47470/0016-9900-2023-102-3-221-228</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Новиков Д.С. Оценка риска здоровью, ассоциированного с пероральным поступлением экотоксикантов из подземных вод Приволжской песчаной гряды // Наука Юга России. 2023. Т. 19. № 1. С. 77-86. doi: 10.7868/25000640230109</mixed-citation><mixed-citation xml:lang="en">Novikov DS. Assessment of the health risk associated with the oral intake of ecotoxicants from groundwater in the Volga sand ridge. Nauka Yuga Rossii. 2023;19(1):77- 86. (In Russ.) doi: 10.7868/25000640230109</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Саташева З.М., Жмыхов Д.В., Кудряшева И.А. Гигие- ническая оценка качества воды источников водоснабжения в регионах Астраханской области // Вестник новых медицинских технологий. Электронное издание. 2023. Т. 17. № 3. С. 68-72. doi: 10.24412/2075-4094-2023-3-2-1</mixed-citation><mixed-citation xml:lang="en">Satasheva ZM, Zhmykhov DV, Kudryasheva IA, Kolomin VV, Kokhanov AV, Devrishov RD. Hygienic assessment of water quality in water supply sources in the regions of the Astrakhan Region. Vestnik Novykh Meditsinskikh Tekhnologiy. 2023;17(3):68-72. (In Russ.) doi: 10.24412/2075-4094-2023-3-2-1</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Богданова О.Г., Ефимова Н.В., Багаева Е.Е. Оценка риска для здоровья населения Республики Бурятия, обусловленного повышенным поступлением нитратов и нитритов Экология человека. 2022. № 1. С. 47-59. doi: 11.17816/humeco83797</mixed-citation><mixed-citation xml:lang="en">Bogdanova OG, Efimova NV, Bagaeva EE. Health risk assessment of the population of the Republic of Buryatia associated with increased nitrate and nitrite intake. Ekologiya Cheloveka (Human Ecology). 2022;(1):47-59. (In Russ.) doi: 10.17816/humeco83797</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Feng W, Wang C, Lei X, Wang H, Zhang X. Distribution of nitrate content in groundwater and evaluation of potential health risks: A case study of rural areas in northern China. Int J Environ Res Public Health. 2020;17(24):9390. doi: 10.3390/ijerph17249390</mixed-citation><mixed-citation xml:lang="en">Feng W, Wang C, Lei X, Wang H, Zhang X. Distribution of nitrate content in groundwater and evaluation of potential health risks: A case study of rural areas in northern China. Int J Environ Res Public Health. 2020;17(24):9390. doi: 10.3390/ijerph17249390</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Su H, Kang W, Xu Y, Wang J. Assessing groundwater quality and health risks of nitrogen pollution in the Shenfu mining area of Shaanxi Province, northwest China. Expo Health. 2018;10:77-97. doi: 10.1007/s12403-017-0247-9</mixed-citation><mixed-citation xml:lang="en">Su H, Kang W, Xu Y, Wang J. Assessing groundwater quality and health risks of nitrogen pollution in the Shenfu mining area of Shaanxi Province, northwest China. Expo Health. 2018;10:77-97. doi: 10.1007/s12403-017-0247-9</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou J, Gu B, Schlesinger WH, Ju X. Significant accumulation of nitrate in Chinese semi-humid croplands. Sci Rep. 2016;6:25088. doi: 10.1038/srep25088</mixed-citation><mixed-citation xml:lang="en">Zhou J, Gu B, Schlesinger WH, Ju X. Significant accumulation of nitrate in Chinese semi-humid croplands. Sci Rep. 2016;6:25088. doi: 10.1038/srep25088</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов А.С., Шепталов В.Б. Опыт орошения сточными водами сельскохозяйственных культур на черноземной почве // Вестник Алтайского государственного аграрного университета. 2022. № 6 (212). С. 43-48. doi: 10.53083/1996-4277-2022-212-6-43-48</mixed-citation><mixed-citation xml:lang="en">Davydov AS, Sheptalov VB. Experience of irrigation of agricultural crops with sewage water on chernozem soil. Vestnik Altaiskogo Gosudarstvennogo Agrarnogo Universiteta. 2022;(6(212)):43-48. (In Russ.) doi: 10.53083/1996-4277-2022-212-6-43-48</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Obuseng VC, Moshoeshoe MN, Nareetsile FM, Kwaambwa H, Maina I. Plant biomass as potential economic commodities for agricultural purposes. Front Chem. 2022;10:806772. doi: 10.3389/fchem.2022.806772</mixed-citation><mixed-citation xml:lang="en">Obuseng VC, Moshoeshoe MN, Nareetsile FM, Kwaambwa H, Maina I. Plant biomass as potential economic commodities for agricultural purposes. Front Chem. 2022;10:806772. doi: 10.3389/fchem.2022.806772</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Parent LE. Vegetable response to added nitrogen and phosphorus using machine learning decryption and the N/P ratio. Horticulturae. 2024;10(4):356. doi: 10.3390/horticulturae10040356</mixed-citation><mixed-citation xml:lang="en">Parent LE. Vegetable response to added nitrogen and phosphorus using machine learning decryption and the N/P ratio. Horticulturae. 2024;10(4):356. doi: 10.3390/horticulturae10040356</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Волкова Е.Н. Влияние уровня азотного и калийного питания на распределение нитратов в растениях столовой свеклы (beta vulgaris L.) // Международный научно-исследовательский журнал. 2024. № 12(150). doi: 10.60797/IRJ.2024.150.27.</mixed-citation><mixed-citation xml:lang="en">Volkova EN. Influence of nitrogen and potassium nutrition levels on nitrate distribution in beetroot (Beta vulgaris L.) plants. Mezhdunarodnyy Nauchno-Issledovatel’skiy Zhurnal. 2024;(12(150)):16. (In Russ.) doi: 10.60797/IRJ.2024.150.27</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Хужамшукуров Н., Эшкобилов Ш., Кучкарова Д., Абдутолибов М. Влияние биогумуса на содержание нитратов в растениях и плодах огурца // Universum: химия и биология. 2023. № 1-1(103). С. 24-29. doi 10.32743/UniChem.2023.103.1.14832</mixed-citation><mixed-citation xml:lang="en">Khujamshukurov N, Eshkobilov Sh, Kuchkarova D, Abdutolibov M. The effect of biohumus on the content of nitrates in cucumber plants and fruits. Universum: Khimiya i Biologiya. 2023;(1-1(103)):24-29. (In Russ.) doi: 10.32743/UniChem.2023.103.1.14832</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Юркова А.А. Содержание нитратов в овощах // Modern Science. 2021. № 6-2. С. 18-21.</mixed-citation><mixed-citation xml:lang="en">Yurkova AA. [Nitrate content in vegetables.] Modern Science. 2021;(6-2):18-21. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Аухадиева Э.А., Даукаев Р.А., Афонькина С.Р. Исследование уровня нитратов в овощах и оценка потенциальных рисков для здоровья // Промышленность и сельское хозяйство. 2023. № 6 (59). С. 49-52.</mixed-citation><mixed-citation xml:lang="en">Aukhadiyeva EA, Daukaev RA, Afonkina SR, Allayarova GR, Fazlyeva AS, Adieva GF. [Research on the level of nitrates in vegetables and assessment of potential health risks.] Promyshlennost’ i Sel’skoe Khozyaystvo. 2023;(6(59)):49-52. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Рымшина М.В., Бойкова О.И., Якушина В.С. Пищевые добавки Е-250 и Е-251 в рационе студентов // Успехи современной науки. 2016. Т. 9. № 12. С. 151-154.</mixed-citation><mixed-citation xml:lang="en">Rymshina MV, Boikova OI, Yakushina VS. Food additives E-250 and E-251 at the ration of students. Uspekhi Sovremennoy Nauki. 2016;9(12):151-154. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hung JH, Zhang SM, Huang SL. Nitrate promotes the growth and the production of short-chain fatty acids and tryptophan from commensal anaerobe Veillonella dispar in the lactate-deficient environment by facilitating the catabolism of glutamate and aspartate. Appl Environ Microbiol. 2024;90(8):e0114824. doi: 10.1128/aem.01148-24</mixed-citation><mixed-citation xml:lang="en">Hung JH, Zhang SM, Huang SL. Nitrate promotes the growth and the production of short-chain fatty acids and tryptophan from commensal anaerobe Veillonella dispar in the lactate-deficient environment by facilitating the catabolism of glutamate and aspartate. Appl Environ Microbiol. 2024;90(8):e0114824. doi: 10.1128/aem.01148-24</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Liu H, Huang Y, Huang M, et al. From nitrate to NO: Potential effects of nitrate-reducing bacteria on systemic health and disease. Eur J Med Res. 2023;28(1):425. doi: 10.1186/s40001-023-01413-y</mixed-citation><mixed-citation xml:lang="en">Liu H, Huang Y, Huang M, et al. From nitrate to NO: Potential effects of nitrate-reducing bacteria on systemic health and disease. Eur J Med Res. 2023;28(1):425. doi: 10.1186/s40001-023-01413-y</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schullehner J, Hansen B, Thygesen M, Pedersen CB, Sigsgaard T. Nitrate in drinking water and colorectal cancer risk: A nationwide population-based cohort study. Int J Cancer. 2018;143(1):73-79. doi: 10.1002/ijc.31306</mixed-citation><mixed-citation xml:lang="en">Schullehner J, Hansen B, Thygesen M, Pedersen CB, Sigsgaard T. Nitrate in drinking water and colorectal cancer risk: A nationwide population-based cohort study. Int J Cancer. 2018;143(1):73-79. doi: 10.1002/ijc.31306</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Espejo-Herrera N, Gràcia-Lavedan E, Boldo E, et al. Colorectal cancer risk and nitrate exposure through drinking water and diet. Int J Cancer. 2016;139(2):334- 346. doi: 10.1002/ijc.30083</mixed-citation><mixed-citation xml:lang="en">Espejo-Herrera N, Gràcia-Lavedan E, Boldo E, et al. Colorectal cancer risk and nitrate exposure through drinking water and diet. Int J Cancer. 2016;139(2):334- 346. doi: 10.1002/ijc.30083</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Fathmawati, Fachiroh J, Gravitiani E, Sarto, Husodo AH. Nitrate in drinking water and risk of colorectal cancer in Yogyakarta, Indonesia. J Toxicol Environ Health A. 2017;80(2):120-128. doi: 10.1080/15287394.2016.1260508</mixed-citation><mixed-citation xml:lang="en">Fathmawati, Fachiroh J, Gravitiani E, Sarto, Husodo AH. Nitrate in drinking water and risk of colorectal cancer in Yogyakarta, Indonesia. J Toxicol Environ Health A. 2017;80(2):120-128. doi: 10.1080/15287394.2016.1260508</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Seyyedsalehi MS, Mohebbi E, Tourang F, Sasanfar B, Boffetta P, Zendehdel K. Association of dietary nitrate, nitrite, and N-nitroso compounds intake and gastrointestinal cancers: A systematic review and meta-analysis. Toxics. 2023;11(2):190. doi: 10.3390/toxics11020190</mixed-citation><mixed-citation xml:lang="en">Seyyedsalehi MS, Mohebbi E, Tourang F, Sasanfar B, Boffetta P, Zendehdel K. Association of dietary nitrate, nitrite, and N-nitroso compounds intake and gastrointestinal cancers: A systematic review and meta-analysis. Toxics. 2023;11(2):190. doi: 10.3390/toxics11020190</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Механтьев И.И. Риск здоровью населения Воронежской области, обусловленный качеством питьевой воды // Здоровье населения и среда обитания. 2020. № 4 (325). С. 37-42. doi: 10.35627/2219-5238/2020-325-4-37-42</mixed-citation><mixed-citation xml:lang="en">Mehantiev II. Health risks for the population of the Voronezh Region related to drinking water quality. Zdorov’e Naseleniya i Sreda Obitaniya. 2020;(4(325)):37-42. (In Russ.) doi: 10.35627/2219-5238/2020-325-4-37-42</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Енин А.В. Влияние химического загрязнения окружающей среды на медико-демографическую ситуацию в Воронежской области // Санитарный врач. 2024. № 5. С. 375-383. doi: 10.33920/med-08-2405-05</mixed-citation><mixed-citation xml:lang="en">Enin AV. The influence of chemical environmental pollution on the medical and demographic situation in the Voronezh Region. Sanitarnyy Vrach. 2024;(5):375-383. (In Russ.) doi: 10.33920/med-08-2405-05</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Механтьев И.И. Обзор исследований в сфере обеспечения гигиенической безопасности рекреационного и питьевого водопользования населения бассейна Верхнего Дона // Санитарный врач. 2020. № 2. С. 63- 72. doi: 10.33920/med-08-2002-08</mixed-citation><mixed-citation xml:lang="en">Mekhantiev II. Review of research in the field of hygiene safety of recreational and drinking water use of the population of the Top Don basin. Sanitarnyy Vrach. 2020;(2):63-72. (In Russ.) doi: 10.33920/med-08-2002-08</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Клепиков О.В., Хатуаев Р.О., Истомин А.В., Румянце- ва Л.А. Региональные особенности питания населения и риск для здоровья, связанный с химической контаминацией пищевых продуктов // Гигиена и санитария. 2016. Т. 95. № 11. С. 1086-1091.</mixed-citation><mixed-citation xml:lang="en">Klepikov OV, Khatuaev RO, Istomin AV, Rumyantseva LA. Regional features of food standards and health risks associated with chemical contamination of food. Gigiena i Sanitariya. 2016;95(11):1086-1091. (In Russ.) doi: 10.18821/0016-9900-2016-95-11-1086-1091</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
