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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2219-5238/2024-32-3-33-43</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-1993</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОММУНАЛЬНАЯ ГИГИЕНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMMUNAL HYGIENE</subject></subj-group></article-categories><title-group><article-title>Проблемы, связанные с загрязнением окружающей среды антибиотиками на примере тетрациклинов (обзор)</article-title><trans-title-group xml:lang="en"><trans-title>Problems Related to Antibiotic Pollution of the Environment: A Review with a Focus on Tetracyclines</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9311-9910</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антропова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Antropova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антропова Наталья Сергеевна – младший научный сотрудник отдела физико-химических исследований и экотоксикологии.</p><p>ул. Погодинская, д. 10, стр. 1, Москва, 191121</p></bio><bio xml:lang="en"><p>Natalia S. Antropova - Junior Researcher, Department of Physical and Chemical Research and Ecotoxicology.</p><p>Bldg 1, 10 Pogodinskaya Street, Moscow, 191121</p></bio><email xlink:type="simple">NAntropova@cspfmba.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2275-9010</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушакова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushakova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ушакова Ольга Владимировна – к.м.н., ведущий научный сотрудник отдела гигиены.</p><p>ул. Погодинская, д. 10, стр. 1, Москва, 191121</p></bio><bio xml:lang="en"><p>Olga V. Ushakova - Cand. Sci. (Med.), Leading Researcher, Department of Hygiene.</p><p>Bldg 1, 10 Pogodinskaya Street, Moscow, 191121</p></bio><email xlink:type="simple">OUshakova@cspmz.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7032-1366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савостикова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Savostikova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Савостикова Ольга Николаевна – к.м.н., начальник отдела физико-химических исследований и экотоксикологии.</p><p>ул. Погодинская, д. 10, стр. 1, Москва, 191121</p></bio><bio xml:lang="en"><p>Olga N. Savostikova - Cand. Sci. (Med.), Head of the Department of Physical and Chemical Research and Ecotoxicology.</p><p>Bldg 1, 10 Pogodinskaya Street, Moscow, 191121</p></bio><email xlink:type="simple">OSavostikova@cspfmba.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5290-3049</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филимонова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Filimonova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филимонова Екатерина Игоревна – химик отдела физико-химических исследований и экотоксикологии.</p><p>ул. Погодинская, д. 10, стр. 1, Москва, 191121</p></bio><bio xml:lang="en"><p>Ekaterina I. Filimonova - chemist, Department of Physical and Chemical Research and Ecotoxicology.</p><p>Bldg 1, 10 Pogodinskaya Street, Moscow, 191121</p></bio><email xlink:type="simple">EFilimonova@cspfmba.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Центр стратегического планирования и управления медико-биологическими рисками здоровью» ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Strategic Planning and Management of Biomedical Health Risks</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>03</month><year>2024</year></pub-date><volume>32</volume><issue>3</issue><fpage>33</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Антропова Н.С., Ушакова О.В., Савостикова О.Н., Филимонова Е.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Антропова Н.С., Ушакова О.В., Савостикова О.Н., Филимонова Е.И.</copyright-holder><copyright-holder xml:lang="en">Antropova N.S., Ushakova O.V., Savostikova O.N., Filimonova E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/1993">https://zniso.fcgie.ru/jour/article/view/1993</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из негативных последствий использования антибиотиков является развитие антибиотикорезистентности. При этом не определен масштаб влияния на данную проблему от попадания антибиотиков в окружающую среду.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: проанализировать имеющиеся данные о распространенности антибиотиков в окружающей среде и связанные с этим проблемами.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Применены информационно-аналитические приемы, основанные на сборе и обработке научных статей, представленных в базах Scopus, Elsevier, РИНЦ за 2003-2023 гг., также применялись поисковые запросы в Google Scholar по ключевым словам. Критерием отбора служило наличие в статьях информации об обнаруженных концентрациях антибиотиков в объектах окружающей среды, путях их поступления, а также рассматриваются вопросы негативных последствий от загрязнения. В итоге отобрано 53 публикации, соответствующих критериям.</p></sec><sec><title>Результаты</title><p>Результаты. Уровень загрязнения воды и почвы антибиотиками близок к уровню загрязнения пестицидами. Резистентность бактерий возникает из-за субингибирующих концентраций антибиотиков, которые в 200 раз меньше</p><p>минимальной ингибирующей концентрации. Существуют исследования, доказывающие влияние на почвенные процессы: снижение почвенного дыхания, изменение скорости нитрификации и денитрификации. В России использование антибиотиков в животноводстве растет на 40% в год, а самыми популярными классами антибиотиков являются пенициллины и тетрациклины. Почва обладает высокой способностью к поглощению антибиотиков, поэтому они быстро накапливаются и медленно разлагаются. Например, период полураспада тетрациклина составляет около 500 дней, а при низком содержании органических веществ в почве риск попадания антибиотика в пищевую цепь и растительную продукцию возрастает.</p></sec><sec><title>Заключение</title><p>Заключение. Непрерывный выброс антибиотиков в окружающую среду и их неблагоприятное воздействие на живые организмы вызывает серьезную озабоченность, требующую дальнейшего изучения в контексте нарушения экологического баланса. Также будущие исследования должны быть направлены на разработку и внедрение методов, минимизирующих распространение генов устойчивости к антибиотикам.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: One of the negative consequences of using antibiotics is the development of antimicrobial resistance. At the same time, the scale of impact of antibiotic pollution in the environment has not been determined so far.</p></sec><sec><title>Objective</title><p>Objective: To analyze data on antibiotics in the environment and associated issues.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: We used information analysis techniques based on collection and processing of scientific articles published in 2003–2023 and presented in such abstract databases as Scopus, Elsevier, and RSCI; Google Scholar keyword search was also done. The selection criterion was availability of information about measured concentrations of antibiotics in various environmental objects, routes of their entry, and adverse effects of antibiotic contamination. Fifty-three publications were found eligible for inclusion in this review.</p></sec><sec><title>Results</title><p>Results: Contamination of water and soil with antibiotics is almost similar to that with pesticides. Bacteria develop resistance to antibiotics due to subinhibitory concentrations of the latter, which are 200 times lower than the minimum inhibitory concentration. Some studies prove that exposure of soil to antibiotics causes a decrease in soil respiration and changes in its nitrification and denitrification rates. In Russia, the use of veterinary antibiotics grows by 40 % annually, while penicillins and tetracyclines remain the most popular classes. Antibiotics are easily adsorbed to soil particles, accumulate quickly and degrade slowly. The half-life of tetracycline, for instance, is about 500 days, and when soil levels of certain substances are low, the risk of antibiotics entering the food chain and plant products increases.</p></sec><sec><title>Conclusion</title><p>Conclusion: The continuous release of antibiotics into the environment and their harmful effects on living organisms is a serious challenge, requiring further study in the context of ecological imbalance. Future research should also focus on developing and implementing methods minimizing the spread of antibiotic resistance genes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>антибиотики в окружающей среде</kwd><kwd>антибиотикорезистентность</kwd><kwd>мировое потребление антибиотиков</kwd><kwd>антибиотики в почве</kwd><kwd>тетрациклины</kwd><kwd>количественное определение тетрациклина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antibiotics in the environment</kwd><kwd>antibiotic resistance</kwd><kwd>global consumption of antibiotics</kwd><kwd>antibiotics in soil</kwd><kwd>tetracyclines</kwd><kwd>tetracycline quantification</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чеснокова С.М., Космачева А.Г. Оценка фитотоксичности и опасности для окружающей среды антибиотиков, используемых в сельском хозяйстве // Инновационные пути решения актуальных. Проблем природопользования и защиты окружающей среды: Материалы докладов Международной научно-технической конференции. / Под редакцией: И.В. Старостина. Том III. Белгород: Белгородский государственный технологический университет им. В.Г. Шухова, 2018. С. 289–295.</mixed-citation><mixed-citation xml:lang="en">Chesnokova SM, Kosmacheva AG. [Assessment of phytotoxicity and environmental hazards of antibiotics used in agriculture.] In: Starostina IV, ed. Innovative Ways of Solving Current Problems of Nature Management and Environmental Protection: Proceedings of the International Scientific and Technical Conference, Alushta, June 4–8, 2018. Belgorod: Belgorod State Technological University named after V.G. Shukhov Publ.; 2018;3:289-295. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tan HM, Lall AC, Keppo J, Chen SL. Evaluation of a new antiresistic strategy to manage antibiotic resistance. J Glob Antimicrob Resist. 2023;33:368-375. doi: 10.1016/j.jgar.2023.03.006</mixed-citation><mixed-citation xml:lang="en">Tan HM, Lall AC, Keppo J, Chen SL. Evaluation of a new antiresistic strategy to manage antibiotic resistance. J Glob Antimicrob Resist. 2023;33:368-375. doi: 10.1016/j.jgar.2023.03.006</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dadgostar P. Antimicrobial resistance: Implications and costs. Infect Drug Resist. 2019;12:3903-3910. doi: 10.2147/IDR.S234610</mixed-citation><mixed-citation xml:lang="en">Dadgostar P. Antimicrobial resistance: Implications and costs. Infect Drug Resist. 2019;12:3903-3910. doi: 10.2147/IDR.S234610</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Давидович Н. В. и др. Основные принципы эволюции антибиотикорезистентности у бактерий (обзор литературы) // Клиническая лабораторная диагностика. 2020. Т. 65. № 6. С. 387–393. doi: 10.1882im69-2084-2020-65-6-387-393</mixed-citation><mixed-citation xml:lang="en">Davidovich NV, Kukalevskaya NN, Bashilova EN, Bazhukova TA. General principles of antibiotic resistance evolution in bacteria (review of literature). Klinicheskaya Laboratornaya Diagnostika. 2020;65(6):387-393. (In Russ.) doi: 10.18821/0869-2084-2020-65-6-387-393</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лаврухина О.И., Амелин В.Г., Киш Л.К. и др. Определение остаточных количеств антибиотиков в объектах окружающей среды и пищевых продуктов // Журнал аналитической химии. 2022. Т. 77. № 11. С. 969–1015. doi: 10.31857/S004445022211007X</mixed-citation><mixed-citation xml:lang="en">Lavrukhina OI, Amelin VG, Kish LK, Tretyakov AV, Pen’kov TD. [Determination of residual amounts of antibiotics in environmental samples and food products.] Zhurnal Analiticheskoy Khimii. 2022;77(11):969-1015. (In Russ.) doi: 10.31857/S004445022211007X</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cycoń M, Mrozik A, Piotrowska-Seget Z. Antibiotics in the soil environment – Degradation and their impact on microbial activity and diversity. Front Microbiol. 2019;10:338. doi: 10.3389/fmicb.2019.00338</mixed-citation><mixed-citation xml:lang="en">Cycoń M, Mrozik A, Piotrowska-Seget Z. Antibiotics in the soil environment – Degradation and their impact on microbial activity and diversity. Front Microbiol. 2019;10:338. doi: 10.3389/fmicb.2019.00338</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Conde-Cid M, Ferreira-Coelho G, Núñez-Delgado A, et al. Competitive adsorption of tetracycline, oxytetracycline and chlortetracycline on soils with different pH value and organic matter content. Environ Res. 2019;178:108669. doi: 10.1016/j.envres.2019.108669</mixed-citation><mixed-citation xml:lang="en">Conde-Cid M, Ferreira-Coelho G, Núñez-Delgado A, et al. Competitive adsorption of tetracycline, oxytetracycline and chlortetracycline on soils with different pH value and organic matter content. Environ Res. 2019;178:108669. doi: 10.1016/j.envres.2019.108669</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Кудинова А.Г., Соина В.С., Максакова С.А., Петрова М.А. Изучение базовой устойчивости к антибиотикам бактерий, выделенных из различных биотопов // Микробиология. 2019. Т. 88. № 6. С. 695–704. doi: 10.1134/S0026365619050094</mixed-citation><mixed-citation xml:lang="en">Kudinova AG, Petrova MA, Soina VS, Maksakova SA. Basic antibiotic resistance of bacteria isolated from different biotopes. Microbiology. 2019;88(6):739-746. doi: 10.1134/S0026365619050094</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Циркунова Ж.Ф. и др. Влияние субингибирующих концентраций биоцидов на формирование адаптивной устойчивости клинических изолятов Klebsiella pneumoniae // Иммунопатология, аллергология, инфектология. 2022. № 3. С. 30–39. doi:10.14427/jipai.2022.3.30</mixed-citation><mixed-citation xml:lang="en">Tsyrkunova ZhF, Emelyanova AA, Gudkova EI, et al. Effect of subinhibitory concentrations of biocides on formation of adaptive resistance of clinical isolates of Klebsiella pneumoniae. Immunopatologiya, Allergologiya, Infektologiya. 2022;(3):30-39. (In Russ.) doi: 10.14427/jipai.2022.3.30</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Berglund B. Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect Ecol Epidemiol. 2015;5:28564. doi: 10.3402/iee.v5.28564</mixed-citation><mixed-citation xml:lang="en">Berglund B. Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect Ecol Epidemiol. 2015;5:28564. doi: 10.3402/iee.v5.28564</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Saima S, Fiaz M, Zafar R, Ahmed I, Arshad M. Dissemination of antibiotic resistance in the environment. In: Hashmi MZ, ed. Antibiotics and Antimicrobial Resistance Genes in the Environment. 2020;1:99-116. doi: 10.1016/B978-0-12-818882-8.00006-1</mixed-citation><mixed-citation xml:lang="en">Saima S, Fiaz M, Zafar R, Ahmed I, Arshad M. Dissemination of antibiotic resistance in the environment. In: Hashmi MZ, ed. Antibiotics and Antimicrobial Resistance Genes in the Environment. 2020;1:99-116. doi: 10.1016/B978-0-12-818882-8.00006-1</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Кожевин П.А., Виноградова К.А., Булгакова В.Г. Почвенная антибиотическая резистома // Вестник Московского Университета. Серия 17. Почвоведение. 2013. № 2. С. 3–10.</mixed-citation><mixed-citation xml:lang="en">Kozhevin PA, Vinogradova KA, Bulgakova VG. Soil antibiotic resistome. Vestnik Moskovskogo Universiteta. Seriya 17: Pochvovedenie. 2013;(2):3-10. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez JL, Sánchez MB, Martínez-Solano L, et al. Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev. 2009;33(2):430–449. doi: 10.1111/j.1574-6976.2008.00157.x</mixed-citation><mixed-citation xml:lang="en">Martinez JL, Sánchez MB, Martínez-Solano L, et al. Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev. 2009;33(2):430–449. doi: 10.1111/j.1574-6976.2008.00157.x</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Orlewska K, Markowicz A, Piotrowska-Seget Z, Smoleń-Dzirba J, Cycoń M. Functional diversity of soil microbial communities in response to the application of cefuroxime and/or antibiotic-resistant Pseudomonas putida strain MC1. Sustainability. 2018;10(10):3549. doi: 10.3390/su10103549</mixed-citation><mixed-citation xml:lang="en">Orlewska K, Markowicz A, Piotrowska-Seget Z, Smoleń-Dzirba J, Cycoń M. Functional diversity of soil microbial communities in response to the application of cefuroxime and/or antibiotic-resistant Pseudomonas putida strain MC1. Sustainability. 2018;10(10):3549. doi: 10.3390/su10103549</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Liu F, Ying GG, Tao R, Zhao JL, Yang JF, Zhao LF. Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environ Pollut. 2009;157(5):1636-1642. doi: 10.1016/j.envpol.2008.12.021</mixed-citation><mixed-citation xml:lang="en">Liu F, Ying GG, Tao R, Zhao JL, Yang JF, Zhao LF. Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environ Pollut. 2009;157(5):1636-1642. doi: 10.1016/j.envpol.2008.12.021</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Grenni P, Ancona V, Caracciolo AB. Ecological effects of antibiotics on natural ecosystems: A review. Microchem J. 2018;136:25-39. doi: 10.1016/j.microc.2017.02.006</mixed-citation><mixed-citation xml:lang="en">Grenni P, Ancona V, Caracciolo AB. Ecological effects of antibiotics on natural ecosystems: A review. Microchem J. 2018;136:25-39. doi: 10.1016/j.microc.2017.02.006</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wepking C, Avera B, Badgley B, et al. Exposure to dairy manure leads to greater antibiotic resistance and increased mass-specific respiration in soil microbial communities. Proc Biol Sci. 2017;284(1851):20162233. doi: 10.1098/rspb.2016.2233</mixed-citation><mixed-citation xml:lang="en">Wepking C, Avera B, Badgley B, et al. Exposure to dairy manure leads to greater antibiotic resistance and increased mass-specific respiration in soil microbial communities. Proc Biol Sci. 2017;284(1851):20162233. doi: 10.1098/rspb.2016.2233</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Toth JD, Feng Y, Dou Z. Veterinary antibiotics at environmentally relevant concentrations inhibit soil iron reduction and nitrification. Soil Biol Biochem. 2011;43(12):2470-2472. doi: 10.1016/j.soilbio.2011.09.004</mixed-citation><mixed-citation xml:lang="en">Toth JD, Feng Y, Dou Z. Veterinary antibiotics at environmentally relevant concentrations inhibit soil iron reduction and nitrification. Soil Biol Biochem. 2011;43(12):2470-2472. doi: 10.1016/j.soilbio.2011.09.004</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cui H, Wang SP, Fu J, Zhou ZQ, Zhang N, Guo L. Influence of ciprofloxacin on microbial community structure and function in soils. Biol Fert Soils. 2014;50:939-947. doi: 10.1007/s00374-014-0914-y</mixed-citation><mixed-citation xml:lang="en">Cui H, Wang SP, Fu J, Zhou ZQ, Zhang N, Guo L. Influence of ciprofloxacin on microbial community structure and function in soils. Biol Fert Soils. 2014;50:939-947. doi: 10.1007/s00374-014-0914-y</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yang JF, Ying GG, Liu S, et al. Biological degradation and microbial function effect of norfloxacin in a soil under different conditions. J Environ Sci Health B. 2012;47(4):288-295. doi: 10.1080/03601234.2012.638886</mixed-citation><mixed-citation xml:lang="en">Yang JF, Ying GG, Liu S, et al. Biological degradation and microbial function effect of norfloxacin in a soil under different conditions. J Environ Sci Health B. 2012;47(4):288-295. doi: 10.1080/03601234.2012.638886</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Molaei A, Lakzian A, Haghnia G, et al. Assessment of some cultural experimental methods to study the effects of antibiotics on microbial activities in a soil: An incubation study. PLoS One. 2017;12(7):e0180663. doi: 10.1371/journal.pone.0180663</mixed-citation><mixed-citation xml:lang="en">Molaei A, Lakzian A, Haghnia G, et al. Assessment of some cultural experimental methods to study the effects of antibiotics on microbial activities in a soil: An incubation study. PLoS One. 2017;12(7):e0180663. doi: 10.1371/journal.pone.0180663</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ma T, Pan X, Chen L, et al. Effects of different concentrations and application frequencies of oxytetracycline on soil enzyme activities and microbial community diversity. Eur J Soil Biol. 2016;76:53-60. doi: 10.1016/j.ejsobi.2016.07.004</mixed-citation><mixed-citation xml:lang="en">Ma T, Pan X, Chen L, et al. Effects of different concentrations and application frequencies of oxytetracycline on soil enzyme activities and microbial community diversity. Eur J Soil Biol. 2016;76:53-60. doi: 10.1016/j.ejsobi.2016.07.004</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Абрамов Е.Г., Антропова Н.С. Влияние антибиотика тетрациклина гидрохлорида на биотрансформацию мочевины // Гигиена и санитария. 2022. Т. 101. № 5. С. 589–595. doi: 10.47470/0016-9900-2022-101-5-589-595</mixed-citation><mixed-citation xml:lang="en">Abramov EG, Antropova NS. The effect of the antibiotic tetracycline hydrochloride on the biotransformation of urea. Gigiena i Sanitariya. 2022;101(5):589-595. (In Russ.) doi: 10.47470/0016-9900-2022-101-5-589-595</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pinna MV, Castaldi P, Deiana P, Pusino A, Garau G. Sorption behavior of sulfamethazine on unamended and manure-amended soils and short-term impact on soil microbial community. Ecotoxicol Environ Saf. 2012;84:234-242. doi: 10.1016/j.ecoenv.2012.07.006</mixed-citation><mixed-citation xml:lang="en">Pinna MV, Castaldi P, Deiana P, Pusino A, Garau G. Sorption behavior of sulfamethazine on unamended and manure-amended soils and short-term impact on soil microbial community. Ecotoxicol Environ Saf. 2012;84:234-242. doi: 10.1016/j.ecoenv.2012.07.006</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Akimenko YV, Kazeev KS, Kolesnikov SI. Impact assessment of soil contamination with antibiotics (For example, an ordinary chernozem). Am J Appl Sci. 2015;12(2):80-88. doi: 10.3844/ajassp.2015.80.88</mixed-citation><mixed-citation xml:lang="en">Akimenko YV, Kazeev KS, Kolesnikov SI. Impact assessment of soil contamination with antibiotics (For example, an ordinary chernozem). Am J Appl Sci. 2015;12(2):80-88. doi: 10.3844/ajassp.2015.80.88</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Liu B, Li Y, Zhang X, Wang J, Gao M. Effects of chlortetracycline on soil microbial communities: Comparisons of enzyme activities to the functional diversity via Biolog EcoPlates™. Eur J Soil Biol. 2015;68:69-76. doi: 10.1016/j.ejsobi.2015.01.002</mixed-citation><mixed-citation xml:lang="en">Liu B, Li Y, Zhang X, Wang J, Gao M. Effects of chlortetracycline on soil microbial communities: Comparisons of enzyme activities to the functional diversity via Biolog EcoPlates™. Eur J Soil Biol. 2015;68:69-76. doi: 10.1016/j.ejsobi.2015.01.002</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Unger IM, Goyne KW, Kennedy AC, Kremer RJ, McLain JE, Williams CF. Antibiotic effects on microbial community characteristics in soils under conservation management practices. Soil Sci Soc Am J. 2013;77(1):100-112. doi: 10.2136/sssaj2012.0099</mixed-citation><mixed-citation xml:lang="en">Unger IM, Goyne KW, Kennedy AC, Kremer RJ, McLain JE, Williams CF. Antibiotic effects on microbial community characteristics in soils under conservation management practices. Soil Sci Soc Am J. 2013;77(1):100-112. doi: 10.2136/sssaj2012.0099</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kuppusamy S, Kakarla D, Venkateswarlu K, Megharaj M, Yoon YE, Lee YB. Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view. Agric Ecosyst Environ. 2018;257:47-59. doi: 10.1016/j.agee.2018.01.026</mixed-citation><mixed-citation xml:lang="en">Kuppusamy S, Kakarla D, Venkateswarlu K, Megharaj M, Yoon YE, Lee YB. Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view. Agric Ecosyst Environ. 2018;257:47-59. doi: 10.1016/j.agee.2018.01.026</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Тимофеева С.С., Гудилова О.С. Антибиотики в окружающей среде: состояние и проблемы // XXI век. Техносферная безопасность. 2021. Т. 6. № 3 (23). С. 251–265. doi: 10.21285/2500-1582-2021-3-251-265</mixed-citation><mixed-citation xml:lang="en">Timofeeva SS, Gudilova OS. Antibiotics in the environment: Status and problems. XXI Vek. Tekhnosfernaya Bezopasnost’. 2021;6(3(23)):251-265. (In Russ.) doi: 10.21285/2500-1582-2021-3-251-265</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Geng J, Liu X, Wang J, Li S. Accumulation and risk assessment of antibiotics in edible plants grown in contaminated farmlands: A review. Sci Total Environ. 2022;853:158616. doi: 10.1016/j.scitotenv.2022.158616</mixed-citation><mixed-citation xml:lang="en">Geng J, Liu X, Wang J, Li S. Accumulation and risk assessment of antibiotics in edible plants grown in contaminated farmlands: A review. Sci Total Environ. 2022;853:158616. doi: 10.1016/j.scitotenv.2022.158616</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jia WL, Song C, He LY, et al. Antibiotics in soil and water: Occurrence, fate, and risk. Curr Opin Environ Sci Health. 2022;32:100437. doi: 10.1016/j.coesh.2022.100437</mixed-citation><mixed-citation xml:lang="en">Jia WL, Song C, He LY, et al. Antibiotics in soil and water: Occurrence, fate, and risk. Curr Opin Environ Sci Health. 2022;32:100437. doi: 10.1016/j.coesh.2022.100437</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rashid A, Muhammad J, Khan S, Kanwal A, Sun Q. Poultry manure gleaned antibiotic residues in soil environment: A perspective of spatial variability and influencing factors. Chemosphere. 2023;317:137907. doi: 10.1016/j.chemosphere.2023.137907</mixed-citation><mixed-citation xml:lang="en">Rashid A, Muhammad J, Khan S, Kanwal A, Sun Q. Poultry manure gleaned antibiotic residues in soil environment: A perspective of spatial variability and influencing factors. Chemosphere. 2023;317:137907. doi: 10.1016/j.chemosphere.2023.137907</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Dong X, Zang J, et al. Antibiotic residues of drinking-water and its human exposure risk assessment in rural Eastern China. Water Res. 2023;236:119940. doi: 10.1016/j.watres.2023.119940</mixed-citation><mixed-citation xml:lang="en">Wang Y, Dong X, Zang J, et al. Antibiotic residues of drinking-water and its human exposure risk assessment in rural Eastern China. Water Res. 2023;236:119940. doi: 10.1016/j.watres.2023.119940</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mousavi L, Tamiji Z, Khoshayand MR. Applications and opportunities of experimental design for the dispersive liquid–liquid microextraction method – A review. Talanta. 2018;190:335-356. doi: 10.1016/j.talanta.2018.08.002</mixed-citation><mixed-citation xml:lang="en">Mousavi L, Tamiji Z, Khoshayand MR. Applications and opportunities of experimental design for the dispersive liquid–liquid microextraction method – A review. Talanta. 2018;190:335-356. doi: 10.1016/j.talanta.2018.08.002</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang F, Wang J, Tian Y, et al. Effective removal of tetracycline antibiotics from water by magnetic functionalized biochar derived from rice waste. Environ Pollut. 2023;330:121681. doi: 10.1016/j.envpol.2023.121681</mixed-citation><mixed-citation xml:lang="en">Zhang F, Wang J, Tian Y, et al. Effective removal of tetracycline antibiotics from water by magnetic functionalized biochar derived from rice waste. Environ Pollut. 2023;330:121681. doi: 10.1016/j.envpol.2023.121681</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wegst-Uhrich S, Navarro DA, Zimmerman L, Aga DS. Assessing antibiotic sorption in soil: A literature review and new case studies on sulfonamides and macrolides. Chem Cent J. 2014;8(1):5. doi: 10.1186/1752-153X-8-5</mixed-citation><mixed-citation xml:lang="en">Wegst-Uhrich S, Navarro DA, Zimmerman L, Aga DS. Assessing antibiotic sorption in soil: A literature review and new case studies on sulfonamides and macrolides. Chem Cent J. 2014;8(1):5. doi: 10.1186/1752-153X-8-5</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Маилян Э.С. Проблема использования антибиотиков в животноводстве и пути контроля микробной антибиотикорезистентности // БИО. 2021. Т. 255. № 12. С. 4.</mixed-citation><mixed-citation xml:lang="en">Mailyan ES. [The problem of the use of antibiotics in animal husbandry and ways to control antimicrobial resistance.] BIO. 2021;(12(255)):4-16. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ришко О. Тетрациклины: взгляд из прошлого в будущее // Животноводство России. 2019. № 1. С. 36–37.</mixed-citation><mixed-citation xml:lang="en">Rishko O. Tetracyclines: Look from the past in the future. Zhivotnovodstvo Rossii. 2019;(1):36-37. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson ML, Levy SB. The history of the tetracyclines. Ann N Y Acad Sci. 2011;1241:17-32. doi: 10.1111/j.1749-6632.2011.06354.x</mixed-citation><mixed-citation xml:lang="en">Nelson ML, Levy SB. The history of the tetracyclines. Ann N Y Acad Sci. 2011;1241:17-32. doi: 10.1111/j.1749-6632.2011.06354.x</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh C. Antibiotics: Actions, Origins, Resistance. Washington, DC: ASM Press; 2003.</mixed-citation><mixed-citation xml:lang="en">Walsh C. Antibiotics: Actions, Origins, Resistance. Washington, DC: ASM Press; 2003.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Мирошникова М. С. Тетрациклиновые антибиотики в животноводстве и ветеринарии // Шаг в науку. 2021. № 2. С. 10–20.</mixed-citation><mixed-citation xml:lang="en">Miroshnikova MS. Tetracycline antibiotics in animal husbandry and veterinary. Shag v Nauku. 2021;(2):10-20. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Rivas J, Encinas Á, Beltrán F, Graham N. Application of advanced oxidation processes to doxycycline and norfloxacin removal from water. J Environ Sci Health A. 2011;46(9):944-951. doi: 10.1080/10934529.2011.586249</mixed-citation><mixed-citation xml:lang="en">Rivas J, Encinas Á, Beltrán F, Graham N. Application of advanced oxidation processes to doxycycline and norfloxacin removal from water. J Environ Sci Health A. 2011;46(9):944-951. doi: 10.1080/10934529.2011.586249</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira-Maia EC, Pereira-Silva P, de Almeida WB, et al. Tetracyclines and glycylcyclines: An overview. Quím Nova. 2010;33(3):700-706. doi: 10.1590/S0100-40422010000300038</mixed-citation><mixed-citation xml:lang="en">Pereira-Maia EC, Pereira-Silva P, de Almeida WB, et al. Tetracyclines and glycylcyclines: An overview. Quím Nova. 2010;33(3):700-706. doi: 10.1590/S0100-40422010000300038</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Forsberg KJ, Reyes A, Wang B, Selleck EM, Sommer MO, Dantas G. The shared antibiotic resistome of soil bacteria and human pathogens. Science. 2012;337(6098):1107-1111. doi: 10.1126/science.1220761</mixed-citation><mixed-citation xml:lang="en">Forsberg KJ, Reyes A, Wang B, Selleck EM, Sommer MO, Dantas G. The shared antibiotic resistome of soil bacteria and human pathogens. Science. 2012;337(6098):1107-1111. doi: 10.1126/science.1220761</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Wu XL, Xiang L, Yan QY, et al. Distribution and risk assessment of quinolone antibiotics in the soils from organic vegetable farms of a subtropical city, Southern China. Sci Total Environ. 2014;487:399-406. doi: 10.1016/j.scitotenv.2014.04.015</mixed-citation><mixed-citation xml:lang="en">Wu XL, Xiang L, Yan QY, et al. Distribution and risk assessment of quinolone antibiotics in the soils from organic vegetable farms of a subtropical city, Southern China. Sci Total Environ. 2014;487:399-406. doi: 10.1016/j.scitotenv.2014.04.015</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Fernández-Calviño D, Bermúdez-Couso A, Arias-Estévez M, et al. Competitive adsorption/desorption of tetracycline, oxytetracycline and chlortetracycline on two acid soils: Stirred flow chamber experiments. Chemosphere. 2015;134:361-366. doi: 10.1016/j.chemosphere.2015.04.098</mixed-citation><mixed-citation xml:lang="en">Fernández-Calviño D, Bermúdez-Couso A, Arias-Estévez M, et al. Competitive adsorption/desorption of tetracycline, oxytetracycline and chlortetracycline on two acid soils: Stirred flow chamber experiments. Chemosphere. 2015;134:361-366. doi: 10.1016/j.chemosphere.2015.04.098</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Pan M, Chu LM. Fate of antibiotics in soil and their uptake by edible crops. Sci Total Environ. 2017;599-600:500-512. doi: 10.1016/j.scitotenv.2017.04.214</mixed-citation><mixed-citation xml:lang="en">Pan M, Chu LM. Fate of antibiotics in soil and their uptake by edible crops. Sci Total Environ. 2017;599-600:500-512. doi: 10.1016/j.scitotenv.2017.04.214</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Kemper N. Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic. 2008;8(1):1-13. doi: 10.1016/j.ecolind.2007.06.002</mixed-citation><mixed-citation xml:lang="en">Kemper N. Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic. 2008;8(1):1-13. doi: 10.1016/j.ecolind.2007.06.002</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S, Wang H. Adsorption behavior of antibiotic in soil environment: A critical review. Front Environ Sci Eng. 2015;9:565-574. doi: 10.1007/s11783-015-0801-2</mixed-citation><mixed-citation xml:lang="en">Wang S, Wang H. Adsorption behavior of antibiotic in soil environment: A critical review. Front Environ Sci Eng. 2015;9:565-574. doi: 10.1007/s11783-015-0801-2</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Okaikue-Woodi FE, Kelch SE, Schmidt MP, Martinez CE, Youngman RE, Aristilde L. Structures and mechanisms in clay nanopore trapping of structurally-different fluoroquinolone antimicrobials. J Colloid Interface Science. 2018;513:367-378. doi: 10.1016/j.jcis.2017.11.020</mixed-citation><mixed-citation xml:lang="en">Okaikue-Woodi FE, Kelch SE, Schmidt MP, Martinez CE, Youngman RE, Aristilde L. Structures and mechanisms in clay nanopore trapping of structurally-different fluoroquinolone antimicrobials. J Colloid Interface Science. 2018;513:367-378. doi: 10.1016/j.jcis.2017.11.020</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Conde-Cid M, Fernández-Calviño D, Nóvoa-Muñoz JC, et al. Biotic and abiotic dissipation of tetracyclines using simulated sunlight and in the dark. Sci Total Environ. 2018;635:1520-1529. doi: 10.1016/j.scitotenv.2018.04.233</mixed-citation><mixed-citation xml:lang="en">Conde-Cid M, Fernández-Calviño D, Nóvoa-Muñoz JC, et al. Biotic and abiotic dissipation of tetracyclines using simulated sunlight and in the dark. Sci Total Environ. 2018;635:1520-1529. doi: 10.1016/j.scitotenv.2018.04.233</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Walters E, McClellan K, Halden RU. Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids–soil mixtures in outdoor mesocosms. Water Res. 2010;44(20):6011-6020. doi: 10.1016/j.watres.2010.07.051</mixed-citation><mixed-citation xml:lang="en">Walters E, McClellan K, Halden RU. Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids–soil mixtures in outdoor mesocosms. Water Res. 2010;44(20):6011-6020. doi: 10.1016/j.watres.2010.07.051</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Scaria J, Anupama KV, Nidheesh PV. Tetracyclines in the environment: An overview on the occurrence, fate, toxicity, detection, removal methods, and sludge management. Sci Total Environ. 2021;771:145291. doi: 10.1016/j.scitotenv.2021.145291</mixed-citation><mixed-citation xml:lang="en">Scaria J, Anupama KV, Nidheesh PV. Tetracyclines in the environment: An overview on the occurrence, fate, toxicity, detection, removal methods, and sludge management. Sci Total Environ. 2021;771:145291. doi: 10.1016/j.scitotenv.2021.145291</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
