<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2219-5238/2024-32-6-81-88</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-1851</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭПИДЕМИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EPIDEMIOLOGY</subject></subj-group></article-categories><title-group><article-title>Характеристики геномов условно-патогенных бактерий зоогенных экосистем островов Западной Арктики</article-title><trans-title-group xml:lang="en"><trans-title>Characteristics of genomes of opportunistic bacteria in zoogenic ecosystems of the Russian Western Arctic Islands</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6890-8096</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асланов</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Aslanov</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Асланов Батырбек Исмелович - д.м.н., заведующий кафедрой эпидемиологии, паразитологии и дезинфектологии; заведующий НИЛмолекулярной эпидемиологии и исследований бактериофагов </p><p>г. Санкт-Петербург, ул. Кирочная, д. 41, 191015</p></bio><bio xml:lang="en"><p>Batyrbek I. Aslanov, Dr. Sci. (Med.), Head of the Department of Epidemiology, Parasitology and Disinfection; Head of the Laboratory of Molecular Epidemiology and Bacteriophage Research</p><p>41 Kirochnaya Street, Saint Petersburg, 191015</p></bio><email xlink:type="simple">batyra@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5206-6656</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончаров</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharov</surname><given-names>A. E</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гончаров Артемий Евгеньевич - д.м.н., заведующий лабораторией функциональной геномики и протеомики микроорганизмов</p><p>г. Санкт-Петербург, ул. Кирочная, д. 41, 191015; ул. Академика Павлова, д. 12, Санкт-Петербург, 197022</p></bio><bio xml:lang="en"><p>Artemiy E. Goncharov, Dr. Sci. (Med.), Head of the Laboratory of Functional Genomics and Proteomics of Microorganisms; Department of Epidemiology, Parasitology and Disinfection</p><p>41 Kirochnaya Street, Saint Petersburg, 191015; 12 Academician Pavlov Street, Saint Petersburg, 197022</p></bio><email xlink:type="simple">phage1@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2483-5144</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азаров</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Azarov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Азаров Даниил Валерьевич - к.м.н., с.н.с. НИЛ молекулярной эпидемиологии и исследований бактериофагов; , н.с. лабораториифункциональной геномики и протеомики микроорганизмов</p><p>г. Санкт-Петербург, ул. Кирочная, д. 41, 191015; ул. Академика Павлова, д. 12, Санкт-Петербург, 197022</p></bio><bio xml:lang="en"><p>Daniil V. Azarov, Cand. Sci. (Med.), Senior Researcher, Laboratory of Molecular Epidemiology and Bacteriophage Research;  Researcher, Laboratory of Functional Genomics and Proteomics of Microorganisms</p><p>41 Kirochnaya Street, Saint Petersburg, 191015; 12 Academician Pavlov Street, Saint Petersburg, 197022</p></bio><email xlink:type="simple">denazarov.da@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7271-2283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трофимова Анна Николаевна - заместитель начальника экспедиционного отряда по научной работе экспедиции «Арктический плавучий университет»</p><p>набережная Северной Двины, д. 17, г. Архангельск, 163002 </p></bio><bio xml:lang="en"><p>Anna N. Trofimova, Deputy Head of the Research Expedition Team at the “Arctic Floating University” expedition</p><p>17 Severnaya Dvina Embankment, Arkhangelsk, 163002</p></bio><email xlink:type="simple">a.trofimova@narfu.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1013-1357</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксенов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аксенов Андрей Сергеевич - к.т.н., профессор кафедры биологии, экологии и биотехнологии, зав. сектором лаборатории арктического биомониторинга</p><p>набережная Северной Двины, д. 17, г. Архангельск, 163002</p></bio><bio xml:lang="en"><p>Andrey S. Aksenov, Cand. Sci. (Tech.), Professor, Department of Biology, Ecology and Biotechnology, Head of the Sector of the Laboratory of Arctic Biomonitoring</p><p>17 Severnaya Dvina Embankment, Arkhangelsk, 163002</p></bio><email xlink:type="simple">a.s.aksenov@narfu.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7094-7561</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мизин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mizin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мизин Иван Андреевич - к.б.н., старший научный сотрудник лаборатории биоресурсов и этнографии</p><p>просп. Никольский, д. 20, г. Архангельск, 163020</p></bio><bio xml:lang="en"><p>Ivan A. Mizin, Cand. Sci. (Biol.), Senior Researcher, Laboratory of Bioresources and Ethnography</p><p>20 Nikolsky Avenue, Arkhangelsk, 163020</p></bio><email xlink:type="simple">mizin@rus-arc.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1537-211X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колоджиева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolodzhieva</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колоджиева Виктория Васильевна - к.м.н., доцент кафедры эпидемиологии, паразитологии и дезинфектологии </p><p>г. Санкт-Петербург, ул. Кирочная, д. 41, 191015</p></bio><bio xml:lang="en"><p>Viktoria V. Kolodzhieva, Cand. Sci. (Med.), Associate Professor, Department of Epidemiology, Parasitology and Disinfection</p><p>41 Kirochnaya Street, Saint Petersburg, 191015</p></bio><email xlink:type="simple">vika-el@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-2960-1397</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кушниренко</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kushnirenko</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кушниренко Дарья Александровна - лаборант лаборатории инновационных методов микробиологического мониторинга научно-образовательного центра научного центра мирового уровня Центр персонализированной медицины</p><p>ул. Академика Павлова, д. 12, Санкт-Петербург, 197022,</p></bio><bio xml:lang="en"><p>Daria A. Kushnirenko, Laboratory Assistant, Laboratory of Innovative Methods of Microbiological Monitoring, World-Class Research Center “Center for Personalized Medicine”</p><p>12 Academician Pavlov Street, Saint Petersburg, 197022</p></bio><email xlink:type="simple">d-kushnirenko@bk.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9115-3250</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краева</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kraeva</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Краева Людмила Александровна - д.м.н., заведующая лабораторией медицинской бактериологии</p><p>Санкт-Петербург, ул. Мира, д. 14, 197101</p></bio><bio xml:lang="en"><p>Lyudmila A. Kraeva, Dr. Sci. (Med.), Head of the Laboratory of Medical Bacteriology</p><p>12 Academician Pavlov Street, Saint Petersburg, 197022</p></bio><email xlink:type="simple">lykraeva@yandex.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6411-0274</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панин</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Panin</surname><given-names>A L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Панин Александр Леонидович - к.м.н., главный специалист по медицинской логистике Логистического центра Российскойантарктической экспедиции</p><p>ул. Беринга, д. 38, 199397, г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Alexander L. Panin, Cand. Sci. (Med.), Chief Specialist for Medical Support for Expeditions</p><p>38 Bering Street, Saint Petersburg, 199397</p></bio><email xlink:type="simple">alp.1952@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7103-3091</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крыленков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylenkov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крыленков Вячеслав Александрович - д.б.н., руководитель центра мониторинга полярных регионов</p><p>Университетская наб., д. 5, г. Санкт-Петербург, 199034</p></bio><bio xml:lang="en"><p>Viacheslav A. Krylenkov, Dr. Sci. (Biol.), Head of the Polar Regions Monitoring сenter</p><p>5 Universitetskaya Embankment, Saint Petersburg, 199034</p></bio><email xlink:type="simple">krylenkoff@gmail.com</email><xref ref-type="aff" rid="aff-8"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I.I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России; ФГБНУ «Институт экспериментальной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western State Medical University named after I.I. Mechnikov; Institute of Experimental Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северный (Арктический) федеральный университет имени М. В. Ломоносова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Northern (Arctic) Federal University named after M.V. Lomonosov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова» Уральского отделения Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБНУ «Институт экспериментальной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Experimental Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФБУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ФГБУ «Арктический и антарктический научно-исследовательский институт»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Arctic and Antarctic Research Institute</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ОО «Санкт-Петербургский союз ученых»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Union of Scientists</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>07</month><year>2024</year></pub-date><volume>32</volume><issue>6</issue><fpage>81</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Асланов Б.И., Гончаров А.Е., Азаров Д.В., Трофимова А.Н., Аксенов А.С., Мизин И.А., Колоджиева В.В., Кушниренко Д.А., Краева Л.А., Панин А.Л., Крыленков В.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Асланов Б.И., Гончаров А.Е., Азаров Д.В., Трофимова А.Н., Аксенов А.С., Мизин И.А., Колоджиева В.В., Кушниренко Д.А., Краева Л.А., Панин А.Л., Крыленков В.А.</copyright-holder><copyright-holder xml:lang="en">Aslanov B.I., Goncharov A.E., Azarov D.V., Trofimova A.N., Aksenov A.S., Mizin I.A., Kolodzhieva V.V., Kushnirenko D.A., Kraeva L.A., Panin A.L., Krylenkov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/1851">https://zniso.fcgie.ru/jour/article/view/1851</self-uri><abstract><sec><title>Введение</title><p>Введение. Арктические экосистемы являются важнейшим объектом микробиологического мониторинга, позволяющего отслеживать динамично меняющуюся природную среду на фоне климатических изменений и промышленного освоения северных территорий.</p><p>Цель исследования заключалась в оценке эпидемического потенциала условно-патогенных бактерий, ассоциированных с животными арктических островов Баренцева и Карского морей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В работе охарактеризованы четыре штамма грамотрицательных условно-патогенных бактерий (Serratia fonticola, Aeromonas salmonicida, Yersinia kristensenii, Yersinia rochesterensis), выделенные в 2021–2022 гг. при микробиологических исследованиях 46 образцов зоогенного биологического материала из природных экосистем острова Вайгач, архипелагов Новая Земля и Земля Франца-Иосифа. Геномы выделенных штаммов микроорганизмов были секвенированы с использованием технологии Illumina MiSeq и после сборки de novo при помощи геномного ассемблера SPAdes 13.0 аннотированы с использованием приложения RAST.</p></sec><sec><title>Результаты</title><p>Результаты. Продемонстрировано, что изученные штаммы располагают рядом факторов вирулентности и генами устойчивости к антибиотикам, что позволяет рассматривать их в качестве потенциальных патогенов. В составе геномов всех изученных бактерий обнаруживаются бета-лактамазы классов A, B, C, из числа факторов патогенности – типичны опероны сидерофоров и систем секреции IV типа. Кроме того, в геномах иерсиний идентифицируется также ген энтеротоксина ytxA коклюшного типа.</p></sec><sec><title>Выводы</title><p>Выводы. Результаты исследования свидетельствуют о возможности формирования природных очагов возбудителей актуальных инфекций на островах высокоширотной Арктики, имеющих перспективы развития туризма, хозяйственного освоения.</p></sec><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: Arctic ecosystems are the most important object of microbiological surveillance that helps monitor a rapidly changing natural environment affected by climate change and industrial development of the northern territories.</p></sec><sec><title>Objective</title><p>Objective: To assess the epidemic potential of opportunistic bacteria associated with animals from the Arctic islands of the Barents and Kara Seas.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: We have studied four strains of gram-negative opportunistic bacteria (Serratia fonticola, Aeromonas salmonicida, Yersinia kristensenii, and Yersinia rochesterensis) isolated in 2021–2022 during microbiological testing of 46 samples of zoogenic biologic materials from the natural ecosystems of Vaigach Island, Novaya Zemlya and Franz Josef Land archipelagos. Genomes of the isolated microbial strains were sequenced using the Illumina MiSeq sequencing system and, after de novo assembly using the SPAdes 13.0 genomic assembler, annotated with RAST (Rapid Annotation using Subsystem Technology).</p></sec><sec><title>Results</title><p>Results: The strains were shown to possess a number of virulence factors and antibiotic resistance genes, which allows them to be considered as potential pathogens. Classes A, B, and C beta-lactamases were found in the genomes of all the bacteria under study, and operons for siderophores and type IV secretion systems were typical of virulence factors. In addition, the pertussis-like YtxA enterotoxin was identified in Yersinia genomes.</p></sec><sec><title>Conclusion</title><p>Conclusion: Our findings indicate the possibility of emergence of natural foci of notifiable infections on the islands in the high-latitude Arctic promising in terms of tourism development and economic growth.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Арктические острова</kwd><kwd>условно-патогенные бактерии</kwd><kwd>полногеномное секвенирование</kwd><kwd>резистом</kwd><kwd>факторы патогенности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Arctic islands</kwd><kwd>opportunistic bacteria</kwd><kwd>genome sequencing</kwd><kwd>resistome</kwd><kwd>pathogenicity factors</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 23-25-00128, https://rscf.ru/project/23-25-00128</funding-statement><funding-statement xml:lang="en">The research was supported by the Russian Science Foundation grant No. 23-25-00128, https://rscf.ru/ project/23-25-00128/.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alsamara I, Ogilvie L, Sudbrak R, Brand A. One Health lens for antimicrobial resistance research and funding: A systematic review. OMICS. 2023;27(12):570-580. doi: 10.1089/omi.2023.0049</mixed-citation><mixed-citation xml:lang="en">Alsamara I, Ogilvie L, Sudbrak R, Brand A. One Health lens for antimicrobial resistance research and funding: A systematic review. OMICS. 2023;27(12):570-580. doi: 10.1089/omi.2023.0049</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">McEwen SA, Collignon PJ. Antimicrobial Resistance: A One Health Perspective. Microbiol Spectr. 2018;6(2). doi: 10.1128/microbiolspec.ARBA-0009-2017</mixed-citation><mixed-citation xml:lang="en">McEwen SA, Collignon PJ. Antimicrobial Resistance: A One Health Perspective. Microbiol Spectr. 2018;6(2). doi: 10.1128/microbiolspec.ARBA-0009-2017</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Panda S, Bhargava B, Gupte MD. One World One Health: Widening horizons. Indian J Med Res. 2021;153(3):241- 243. doi: 10.4103/ijmr.ijmr_1056_21</mixed-citation><mixed-citation xml:lang="en">Panda S, Bhargava B, Gupte MD. One World One Health: Widening horizons. Indian J Med Res. 2021;153(3):241- 243. doi: 10.4103/ijmr.ijmr_1056_21</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Naddeo V. One planet, one health, one future: The environmental perspective. Water Environ Res. 2021;93(9):14721475. doi: 10.1002/wer.1624</mixed-citation><mixed-citation xml:lang="en">Naddeo V. One planet, one health, one future: The environmental perspective. Water Environ Res. 2021;93(9):14721475. doi: 10.1002/wer.1624</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Коренберг Э.И. Природная очаговость инфекций: современные проблемы и перспективы исследований // Зоологический журнал. 2010. Т. 89, № 1. С. 5–17.</mixed-citation><mixed-citation xml:lang="en">Korenberg EI. Natural focality of infections: Current problems and prospects of investigations. Zoologicheskiy Zhurnal. 2010;89(1):5-17. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Deviatkin AA, Vakulenko YA, Dashian MA, Lukashetv AA. Evaluating the impact of anthropogenic factors on the dissemination of contemporary cosmopolitan, Arctic, and Arctic-like rabies viruses. Viruses. 2021;14(71):66. doi: 10.3390/v14010066</mixed-citation><mixed-citation xml:lang="en">Deviatkin AA, Vakulenko YA, Dashian MA, Lukashetv AA. Evaluating the impact of anthropogenic factors on the dissemination of contemporary cosmopolitan, Arctic, and Arctic-like rabies viruses. Viruses. 2021;14(71):66. doi: 10.3390/v14010066</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gass JD Jr, Kellogg HK, Hill NJ, Puryear WB, Nutter FB, Runstadler JA. Epidemiology and ecology of influenza A viruses among wildlife in the Arctic. Viruses. 2022;14(7):e1531. doi: 10.3390/v14071531</mixed-citation><mixed-citation xml:lang="en">Gass JD Jr, Kellogg HK, Hill NJ, Puryear WB, Nutter FB, Runstadler JA. Epidemiology and ecology of influenza A viruses among wildlife in the Arctic. Viruses. 2022;14(7):e1531. doi: 10.3390/v14071531</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Liskova EA, Egorova IY, Selyaninov YO, et al. Reindeer anthrax in the Russian Arctic, 2016: Climatic determinants of the outbreak and vaccination effectiveness. Front Vet Sci. 2021;8:e668420. doi: 10.3389/fvets.2021.668420</mixed-citation><mixed-citation xml:lang="en">Liskova EA, Egorova IY, Selyaninov YO, et al. Reindeer anthrax in the Russian Arctic, 2016: Climatic determinants of the outbreak and vaccination effectiveness. Front Vet Sci. 2021;8:e668420. doi: 10.3389/fvets.2021.668420</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bettencourt LMA, Ribeiro RM. Real time Baysian estimation of the epidemic potential of emerging infectious diseases. PloS One. 2008;3(5):e2185. doi: 10.1371/journal. pone.0002185</mixed-citation><mixed-citation xml:lang="en">Bettencourt LMA, Ribeiro RM. Real time Baysian estimation of the epidemic potential of emerging infectious diseases. PloS One. 2008;3(5):e2185. doi: 10.1371/journal.pone.0002185</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Suarez G, Khajanchi BK, Sierra JC, Erova TE, Sha J, Chopra AK. Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis. Gene. 2012;506(2):369-376. doi: 10.1016/j. gene.2012.07.012</mixed-citation><mixed-citation xml:lang="en">Suarez G, Khajanchi BK, Sierra JC, Erova TE, Sha J, Chopra AK. Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis. Gene. 2012;506(2):369-376. doi: 10.1016/j.gene.2012.07.012</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Faure E, Kwong K., Nguyen D. Pseudomonas aeruginosa in chronic lung infections: How to adapt within the host? Front Immunol. 2018;9:2416. doi: 10.3389/fimmu.2018.02416</mixed-citation><mixed-citation xml:lang="en">Faure E, Kwong K., Nguyen D. Pseudomonas aeruginosa in chronic lung infections: How to adapt within the host? Front Immunol. 2018;9:2416. doi: 10.3389/fimmu.2018.02416</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Littler DR, Ang SY, Moriel DG, et al. Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins. J Biol Chem. 2017;292(36):1514315158. doi: 10.1074/jbc.M117.796094</mixed-citation><mixed-citation xml:lang="en">Littler DR, Ang SY, Moriel DG, et al. Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins. J Biol Chem. 2017;292(36):1514315158. doi: 10.1074/jbc.M117.796094</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Young VB, Miller VL, Falkow S, Schoolnik GK. Sequence, localization and function of the invasion protein of Yersinia enterocolitica. Mol Microbiol. 1990;4(7):1119-1128. doi: 10.1111/j.1365-2958.1990.tb00686.x</mixed-citation><mixed-citation xml:lang="en">Young VB, Miller VL, Falkow S, Schoolnik GK. Sequence, localization and function of the invasion protein of Yersinia enterocolitica. Mol Microbiol. 1990;4(7):1119-1128. doi: 10.1111/j.1365-2958.1990.tb00686.x</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Podladchikova O, Antonenka U, Heesemann J, Rakin A. Yersinia pestis autoagglutination factor is a component of the type six secretion system. Int J Med Microbiol. 2011;301(7):562-569. doi: 10.1016/j.ijmm.2011.03.004</mixed-citation><mixed-citation xml:lang="en">Podladchikova O, Antonenka U, Heesemann J, Rakin A. Yersinia pestis autoagglutination factor is a component of the type six secretion system. Int J Med Microbiol. 2011;301(7):562-569. doi: 10.1016/j.ijmm.2011.03.004</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wang P, Dong JF, Li RQ, Li L, Zou QH. Roles of the Hcp family proteins in the pathogenicity of Salmonella typhimurium 14028s. Virulence. 2020; 11(1):1716-1726. doi: 10.1080/21505594.2020.1854538</mixed-citation><mixed-citation xml:lang="en">Wang P, Dong JF, Li RQ, Li L, Zou QH. Roles of the Hcp family proteins in the pathogenicity of Salmonella typhimurium 14028s. Virulence. 2020; 11(1):1716-1726. doi: 10.1080/21505594.2020.1854538</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dallaire-Dufresne S, Tanaka KH, Trudel MV, Lafaille A, Charette SJ. Virulence, genomic features, and plasticity of Aeromonas salmonicida subsp. salmonicida, the causative agent of fish furunculosis. Vet Microbiol. 2014;169(1-2):1- 7. doi: 10.1016/j.vetmic.2013.06.025</mixed-citation><mixed-citation xml:lang="en">Dallaire-Dufresne S, Tanaka KH, Trudel MV, Lafaille A, Charette SJ. Virulence, genomic features, and plasticity of Aeromonas salmonicida subsp. salmonicida, the causative agent of fish furunculosis. Vet Microbiol. 2014;169(1-2):1- 7. doi: 10.1016/j.vetmic.2013.06.025</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hernández J, González-Acuña D. Anthropogenic antibiotic resistance genes mobilization to the polar regions. Infect Ecol Epidemiol. 2016;6:e32112. doi: 10.3402/iee.v6.32112</mixed-citation><mixed-citation xml:lang="en">Hernández J, González-Acuña D. Anthropogenic antibiotic resistance genes mobilization to the polar regions. Infect Ecol Epidemiol. 2016;6:e32112. doi: 10.3402/iee.v6.32112</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tan L, Li L, Ashbolt N, Wang X. et al. Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin. Sci Total Environ. 2018 Apr 15;621:1176-1184. doi: 10.1016/j.scitotenv.2017.10.110</mixed-citation><mixed-citation xml:lang="en">Tan L, Li L, Ashbolt N, Wang X. et al. Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin. Sci Total Environ. 2018 Apr 15;621:1176-1184. doi: 10.1016/j.scitotenv.2017.10.110</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Haan TJ, Drown DM. Unearthing Antibiotic Resistance Associated with Disturbance-Induced Permafrost Thaw in Interior Alaska. Microorganisms. 2021;9(1):e116. doi: 10.3390/microorganisms9010116</mixed-citation><mixed-citation xml:lang="en">Haan TJ, Drown DM. Unearthing Antibiotic Resistance Associated with Disturbance-Induced Permafrost Thaw in Interior Alaska. Microorganisms. 2021;9(1):e116. doi: 10.3390/microorganisms9010116</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sunde M, Ramstad SN, Rudi K, et al. Plasmid-associated antimicrobial resistance and virulence genes in Escherichia coli in a high arctic reindeer subspecies. J Glob Antimicrob Resist. 2021; 26: 317-322. doi: 10.1016/j.jgar.2021.06.003</mixed-citation><mixed-citation xml:lang="en">Sunde M, Ramstad SN, Rudi K, et al. Plasmid-associated antimicrobial resistance and virulence genes in Escherichia coli in a high arctic reindeer subspecies. J Glob Antimicrob Resist. 2021; 26: 317-322. doi: 10.1016/j.jgar.2021.06.003</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврило М.В., Мартынова Д.М. Сохранение редких видов морской фауны и флоры, занесенных в Красную книгу Российской Федерации и Красный список МСОП, в национальном парке «Русская Арктика» // Nature Conservation Research. Заповедная наука. 2017. Т. 2 (S1). С. 10–42. doi: 10.24189/ncr.2017.017</mixed-citation><mixed-citation xml:lang="en">Gavrilo MV, Martynova DM. Conservation of rare species of marine flora and fauna of the Russian Arctic National Park, included in the Red Data Book of the Russian Federation and in the IUCN Red List. Nature Conservation Research. 2017;2(S1):10-42. (In Russ.) doi: 10.24189/ncr.2017.017</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vecherskii MV, Kuznetsova TA, Khayrullin DR, et al. Anthropogenic neighborhood impact on bacterial and fungal communities in polar bear feces. Animals (Basel). 2023;13(13):2067. doi: 10.3390/ani13132067</mixed-citation><mixed-citation xml:lang="en">Vecherskii MV, Kuznetsova TA, Khayrullin DR, et al. Anthropogenic neighborhood impact on bacterial and fungal communities in polar bear feces. Animals (Basel). 2023;13(13):2067. doi: 10.3390/ani13132067</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen SV, Cunningham SA, Jeraldo P, Tran A, Patel R. Yersinia occitanica is a later heterotypic synonym of Yersinia kristensenii subsp. rochesterensis and elevation of Yersinia kristensenii subsp. rochesterensis to species status. International Journal of Systematic Evol Microbiol Bacteriology. 2021;71(2):004626. doi: 10.1099/ijsem.0.004626</mixed-citation><mixed-citation xml:lang="en">Nguyen SV, Cunningham SA, Jeraldo P, Tran A, Patel R. Yersinia occitanica is a later heterotypic synonym of Yersinia kristensenii subsp. rochesterensis and elevation of Yersinia kristensenii subsp. rochesterensis to species status. International Journal of Systematic Evol Microbiol Bacteriology. 2021;71(2):004626. doi: 10.1099/ijsem.0.004626</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Панин А.Л. Микробиологический мониторинг возбудителей сапрозоонозов в полярных регионах: дис. ... канд. мед. наук. Москва, 2023. Доступно по: https://www.rudn.ru/storage/media/science_dissertation/9fb83289-26d1-4a 4b-a31a-3a4bf616380a/panin-dissertaciya-100423.pdf. Ссылка активна на 28.06.2024.</mixed-citation><mixed-citation xml:lang="en">Panin AL. [Microbiological monitoring of sapro-zoonotic pathogenes in polar regions.] Candidate of Medical Sciences thesis. Moscow; 2023. (In Russ.) Accessed June 28, 2024. https://www.rudn.ru/storage/media/science_dissertation/9fb83289-26d1-4a4b-a31a-3a4bf616380a/panin-dissertaciya-100423.pdf</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Virdi JS, Sachdeva P. Molecular heterogeneity in Yersinia enterocolitica and Y. enterocolitica-like' species – Implications for epidemiology, typing and taxonomy. FEMS Immunol Med Microbiol. 2005;45(1):1-10. doi: 10.1016/j. femsim.2005.03.006</mixed-citation><mixed-citation xml:lang="en">Virdi JS, Sachdeva P. Molecular heterogeneity in Yersinia enterocolitica and Y. enterocolitica-like' species – Implications for epidemiology, typing and taxonomy. FEMS Immunol Med Microbiol. 2005;45(1):1-10. doi: 10.1016/j.femsim.2005.03.006</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
