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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2219-5238/2023-31-5-78-84</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-1500</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИГИЕНА ТРУДА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OCCUPATIONAL HEALTH</subject></subj-group></article-categories><title-group><article-title>Возрастная динамика риска COVID-19 разной степени выраженности у работников здравоохранения и промышленных предприятий</article-title><trans-title-group xml:lang="en"><trans-title>Age-Specific Dynamics of Risks of COVID-19 of Different Severity among Healthcare and Industrial Workers</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1297-5476</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокин</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokin</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокин Геннадий Александрович – д.б.н., ведущий научный сотрудник отдела анализа рисков здоровью населения</p><p>2-я Советская ул., д. 4, 191036, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Gennady A. Sorokin, Dr. Sci. (Biol.), Leading Researcher, Department of Health Risk Analysis</p><p>4, 2nd Sovetskaya Street, Saint Petersburg, 191036</p></bio><email xlink:type="simple">sorgen50@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1881-3432</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чистяков</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Chistyakov</surname><given-names>N. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чистяков Николай Дмитриевич – к.м.н., врач-дерматовенеролог отдела клинических исследований</p><p>2-я Советская ул., д. 4, 191036, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Nikolay D. Chistyakov, Cand. Sci. (Med.), Dermatovenereologist, Clinical Research Department</p><p>4, 2nd Sovetskaya Street, Saint Petersburg, 191036</p></bio><email xlink:type="simple">ndvision@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7810-4713</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернышева</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernysheva</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернышева Марина Павловна – д.б.н., профессор</p><p>Кондратьевский пр., д. 72, лит. А, 195009, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Marina P. Chernysheva, Dr. Sci. (Biol.), Professor</p><p>72A, Kondratievsky Avenue, Saint Petersburg, 195009</p></bio><email xlink:type="simple">mp_chern@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9037-0301</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирьянова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kir'yanova</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кирьянова Марина Николаевна – к.м.н., старший научный сотрудник отдела анализа рисков здоровью населения</p><p>2-я Советская ул., д. 4, 191036, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Marina N. Kir'yanova, Cand. Sci. (Med.), Senior Researcher, Department of Health Risk Analysis</p><p>4, 2nd Sovetskaya Street, Saint Petersburg, 191036</p></bio><email xlink:type="simple">mrn@ro.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Северо-Западный научный центр гигиены и общественного здоровья» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Northwest Public Health Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЧОУ ВО «Санкт-Петербургский медико-социальный институт»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg Medical and Social Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>06</month><year>2023</year></pub-date><volume>31</volume><issue>5</issue><fpage>78</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сорокин Г.А., Чистяков Н.Д., Чернышева М.П., Кирьянова М.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Сорокин Г.А., Чистяков Н.Д., Чернышева М.П., Кирьянова М.Н.</copyright-holder><copyright-holder xml:lang="en">Sorokin G.A., Chistyakov N.D., Chernysheva M.P., Kir'yanova M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/1500">https://zniso.fcgie.ru/jour/article/view/1500</self-uri><abstract><p>Введение. Актуальность для общественного здоровья вопроса уязвимости человека в разном возрасте к воздействию факторов окружающей среды, в частности к биологическому фактору, включая вирусные инфекции, обусловлена старением населения и требованиями учета индивидуальных характеристик для более точной оценки рисков.Цель: установление закономерностей возрастной динамики рисков COVID-19 разной степени выраженности у работников организаций здравоохранения и промышленных предприятий.Материалы и методы. Анализировалась частота и степень выраженности COVID-19 за 2021–2022 годы у 729 работников здравоохранения и 880 работников промышленных предприятий. В каждой возрастной группе определялся риск COVID-19 легкой, средней и тяжелой степени. Возрастная динамика риска COVID-19 характеризовалась его изменением при увеличении возраста работников на 1 год.Результаты. Распространенность случаев COVID-19 среди работников здравоохранения в 1,6 раза выше, чем у работников промышленных предприятий. Установлены закономерности возрастной динамики риска COVID-19 разной степени тяжести у работников здравоохранения и промышленных предприятий. При легкой степени выраженности риск аппроксимируется регрессиями: здравоохранение Ri 1 (%) = –0,15 × (Возраст – 20, лет) + 34,06; промпредприятия Ri 1 (%) = –0,24 × (Возраст – 20) + 27,21. При средней и тяжелой степени: в здравоохранении Ri 2,3 (%) = 0,23 × (Возраст – 20) + 2,46; промпредприятия Ri 2,3 (%) = 0,14 × (Возраст – 20) – 1,29.Выводы. В разных возрастных группах относительный риск заболеваемости COVID-19 в легкой форме у работников здравоохранения в 1,2–2,1 раза выше, чем у работников промышленности; средней и тяжелой степени – в 3–9 раза. Направленность возрастной динамики популяционного риска заболеваемости COVID-19 зависит от степени тяжести заболевания. При легкой степени увеличение возраста на 1 год сопровождается уменьшением риска заболевания в среднем на 0,15 % у работников здравоохранения и на 0,24 % у работников промышленности. При средней и тяжелой степени увеличение возраста на 1 год сопровождается возрастанием риска COVID-19 на 0,23 % у работников здравоохранения и на 0,14 % у работников промышленности.</p></abstract><trans-abstract xml:lang="en"><p>Introduction: The relevance of the issue of human age-specific vulnerability to effects of environmental factors, especially biological agents, including viral infections, for public health is attributed to the aging of the population and the requirements for considering individual characteristics for a more accurate risk assessment.Objective: To establish age-specific patterns of the COVID-19 risk among healthcare and industrial workers.Materials and methods: We have analyzed the incidence and course of COVID-19 among 729 healthcare workers and 880 industrial workers in 2021–2022. The risk of mild, moderate and severe course of COVID-19 was determined in each age group. The age-specific dynamics of the COVID-19 risk was characterized by its change per year of age of the employees.Results: We established that the incidence of COVID-19 among healthcare workers was 1.6 times higher than among industrial workers. We also observed regularities of the age-specific dynamics of risk of COVID-19 of different severity among healthcare and industrial workers. For the mild course of the disease, the risk was approximated by the following regressions: healthcare Ri 1 (%) = –0.15 × (Age – 20, years) + 34.06; industry Ri 1 (%) = –0.24 × (Age – 20) + 27.21. For the moderate and severe course, the regressions were as follows: healthcare Ri 2,3 (%) = 0.23 × (Age – 20) + 2.46; industry Ri 2.3(%) = 0.14×(Age – 20) – 1.29.Conclusions: In different age groups, the relative risk of a mild course of COVID-19 in healthcare workers is 1.2–2.1 times higher than in industrial workers while that of a moderate and severe course is already 3 to 9 times higher. The direction of the age-specific COVID-19 risk depends on the disease severity. As for the mild course, a one-year increase in age is associated with a decrease in the disease risk by an average of 0.15 % in healthcare workers and 0.24 % in industrial workers. As for the moderate and severe courses, a one-year increase in age is associated with an increase in the COVID-19 risk by 0.23 % and 0.14 % in healthcare and industrial workers, respectively.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>возрастная уязвимость</kwd><kwd>COVID-19</kwd><kwd>возрастная динамика риска</kwd><kwd>регрессионные модели риска</kwd><kwd>работники здравоохранения</kwd><kwd>работники промышленных предприятий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>age-specific vulnerability</kwd><kwd>COVID-19</kwd><kwd>age-related risk dynamics</kwd><kwd>regression risk models</kwd><kwd>healthcare workers</kwd><kwd>industrial workers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">van Kamp I, Davies H. Noise and health in vulnerable groups: a review. 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