sredobЗдоровье населения и среда обитания – ЗНиСОPublic Health and Life Environment – PH&LE2219-52382619-0788ФБУЗ ФЦГиЭ Роспотребнадзора10.35627/2219-5238/2023-31-9-51-57sredob-1322Research ArticleКОММУНАЛЬНАЯ ГИГИЕНАCOMMUNAL HYGIENEК оценке потенциальной опасности селенсодержащих наночастиц на разных уровнях организации живого (обзор литературы)On Assessment of Potential Hazards of Selenium Nanoparticles at Different Levels of Organization of Living Things: A Literature Reviewhttps://orcid.org/0000-0003-2677-0479РябоваЮ. В.RyabovaYu. V.

Рябова Юлия Владимировна – научный сотрудник, заведующий лабораторией научных основ биологической профи¬лактики отдела токсикологии и биопрофилактики

ул. Попова, д. 30, г. Екатеринбург, 620014

Yuliya V. Ryabova, Researcher, Head of the Laboratory of Scientific Fundamentals of Biological Prophylaxis, Department of Toxicology and Bioprophylaxis

30 Popov Street, Yekaterinburg, 620014

ryabovaiuvl@gmail.comhttps://orcid.org/0000-0002-1743-7642СутунковаМ. П.SutunkovaM. P.

Сутункова Марина Петровна – д.м.н., директор

ул. Попова, д. 30, г. Екатеринбург, 620014

Marina P. Sutunkova, Dr. Sci. (Med.), Director

30 Popov Street, Yekaterinburg, 620014

sutunkova@ymrc.ruhttps://orcid.org/0000-0002-0097-7845МинигалиеваИ. А.MinigalievaI. A.

Минигалиева Ильзира Амировна – д.б.н., заведующая отделом токсикологии и биопрофилактики

ул. Попова, д. 30, г. Екатеринбург, 620014

Ilzira A. Minigalieva, Dr. Sci. (Biol.), Head of the Department of Toxicology and Bioprophylaxis

30 Popov Street, Yekaterinburg, 620014

ilzira-minigalieva@yandex.ruФБУН «Екатеринбургский медицинский-научный центр профилактики и охраны здоровья рабочих промпредприятий» РоспотребнадзораРоссияYekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial WorkersRussian Federation2023051020233195157Copyright © Рябова Ю.В., Сутункова М.П., Минигалиева И.А., 20232023Рябова Ю.В., Сутункова М.П., Минигалиева И.А.Ryabova Y.V., Sutunkova M.P., Minigalieva I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zniso.fcgie.ru/jour/article/view/1322

Введение. Распространение селенсодержащих наночастиц (Se-НЧ) увеличивает риск загрязнения ими объектов окружающей среды и экспозиции населения случайным образом либо в качестве целенаправленного применения продукции, содержащей Se-НЧ. Это делает актуальной оценку потенциальной опасности Se-НЧ.Цель: на основании научных публикаций проанализировать данные для последующей оценки потенциальной опасности Se-НЧ как фактора риска производственной и окружающей среды на разных уровнях организации живого.Материалы и методы. Осуществлен научный обзор исследований на русском и английском языках с использованием информационных порталов и платформ PubMed, Google Scholar, eLibrary, CyberLeninka, Scopus за период 2001–2022 гг. Поиск осуществлялся по ключевым словам: наночастицы селена, токсичность, цитотоксичность, патология, опасность, риск. Были включены оригинальные исследования, в которых исследуемым веществом являлись селенсодержащие наночастицы. После первичного анализа из более чем 100 первоначально выявленных статей было отобрано 45 публикаций.Результаты. При применении Se-НЧ чаще учитываются их положительные свойства, но не отрицательные. Тем не менее установлена способность Se-НЧ генерировать свободные радикалы, проявлять цитотоксическое действие на опухолевые клетки, а также взаимодействовать с белками, хотя и без изменений их вторичной структуры. Имеются данные об острой и подострой токсичности Se-НЧ, в том числе на теплокровных животных, информация о накоплении в культурах сельскохозяйственных растений.Заключение. Для оценки уровня потенциальной опасности Se-НЧ необходимы дополнительные исследования, направленные на уточнение их физико-химических свойств, токсикологической и эколого-гигиенической характеристики.

Introduction: The spread of selenium nanoparticles (Se NPs) increases risks of environmental pollution and human exposure, either accidental or following a targeted use of the products known to contain them, making the assessment of potential hazards of Se NPs particularly relevant.Objective: To examine published data for subsequent assessment of potential hazards of selenium nanoparticles as a risk factor in both occupational and environmental settings at different levels of organization of living things.Materials and methods: We have analyzed the results of studies published in 2001–2022 in English and Russian languages and found in PubMed, Google Scholar, eLibrary, CyberLeninka, and Scopus databases using the following keywords: selenium nanoparticles, toxicity, cytotoxicity, pathology, hazard, and risk. Forty-five original research articles were considered eligible for inclusion in the review out of more than 100 papers screened for information of interest.Results: We have noted that health benefits of using Se NPs are discussed more frequently than their adverse effects. Yet, the ability of Se NPs to generate free radicals, exhibit a cytotoxic effect on tumor cells, and interact with proteins, although without changes in their secondary structure, has been established. Some authors also report acute and subacute toxicity of Se NPs observed, inter alia, in warm-blooded animals, as well as their accumulation in agricultural plants.Conclusion: Additional in-depth studies of physicochemical, toxicological, and hygienic characteristics of selenium nanoparticles are necessary to specify the extent of their potential hazard for living things.

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The authors declare that there are no conflicts of interest present.