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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sredob</journal-id><journal-title-group><journal-title xml:lang="ru">Здоровье населения и среда обитания – ЗНиСО</journal-title><trans-title-group xml:lang="en"><trans-title>Public Health and Life Environment – PH&amp;LE</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-5238</issn><issn pub-type="epub">2619-0788</issn><publisher><publisher-name>ФБУЗ ФЦГиЭ Роспотребнадзора</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.35627/2022-30-12-66-72</article-id><article-id custom-type="elpub" pub-id-type="custom">sredob-1171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАДИАЦИОННАЯ ГИГИЕНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RADIATION HYGIENE</subject></subj-group></article-categories><title-group><article-title>База данных когорты персонала Сибирского химического комбината, задействованного в работе с соединениями урана</article-title><trans-title-group xml:lang="en"><trans-title>Database of the Cohort of Workers of the Siberian Chemical Plant Exposed to Uranium Compounds</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6948-6075</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинкин</surname><given-names>Д. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinkin</surname><given-names>D. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калинкин Дмитрий Евгеньевич – д.м.н., доцент, ведущий научный сотрудник; профессор кафедры общей и детской урологии-андрологии</p><p>Чекист пер., д. 7, к. 2, г. Северск, Томская обл., 636013</p><p>Московский тракт, д. 2, г. Томск, 634050</p></bio><bio xml:lang="en"><p>Dmitry E. Kalinkin, Dr. Sci. (Med.), Assoc. Prof., Leading Researcher; Professor, Department of General and Pediatric Urology and Andrology</p><p>Bldg 2, 7 Chekist Lane, Seversk, Tomsk Region, 636013</p><p>2 Moskovsky Tract, Tomsk, 634050</p></bio><email xlink:type="simple">kalinkin750@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8712-5815</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тахауов</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Takhauov</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тахауов Анас Равильевич – младший научный сотрудник</p><p>Чекист пер., д. 7, к. 2, г. Северск, Томская обл., 636013</p></bio><bio xml:lang="en"><p>Anas R. Takhauov, Junior Researcher</p><p>Bldg 2, 7 Chekist Lane, Seversk, Tomsk Region, 636013</p><p> </p></bio><email xlink:type="simple">Anas.t@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6261-9795</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тахауова</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Takhauova</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тахауова Лилия Равильевна – младший научный сотрудник; аспирант кафедры офтальмологии</p><p>Чекист пер., д. 7, к. 2, г. Северск, Томская обл., 636013</p><p>Московский тракт, д. 2, г. Томск, 634050</p></bio><bio xml:lang="en"><p>Lilia R. Takhauova, Junior Researcher; Postgraduate student, Department of Ophthalmology</p><p>Bldg 2, 7 Chekist Lane, Seversk, Tomsk Region, 636013</p><p>2 Moskovsky Tract, Tomsk, 634050</p></bio><email xlink:type="simple">tahauovaa@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойлова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoilova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самойлова Юлия Александровна – заведующая отделением медицинской статистики ФГБУ «Сибирский федеральный научно-клинический центр»</p><p>ул. Мира, д. 4, г. Северск, Томская обл., 636035</p></bio><bio xml:lang="en"><p>Yulia A. Samoilova, Head of the Department of Medical Statistics</p><p>4 Mira Street, Seversk, Tomsk Region, 636035</p></bio><email xlink:type="simple">kb81@med.tomsk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9764-4392</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мильто</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Milto</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мильто Иван Васильевич – д.б.н., доцент, заместитель директора по научной работе; профессор кафедры морфологии и общей патологии </p><p>Чекист пер., д. 7, к. 2, г. Северск, Томская обл., 636013</p><p>Московский тракт, д. 2, г. Томск, 634050</p></bio><bio xml:lang="en"><p>Ivan V. Milto, Dr. Sci. (Biol.), Assoc. Prof., Deputy Director for Research</p><p>Bldg 2, 7 Chekist Lane, Seversk, Tomsk Region, 636013</p><p>2 Moskovsky Tract, Tomsk, 634050</p></bio><email xlink:type="simple">milto_bio@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1994-957X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тахауов</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Takhauov</surname><given-names>R. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тахауов Равиль Манихович – д.м.н., профессор, заслуженный врач Российской Федерации, директор; профессор кафедры организации здравоохранения и общественного здоровья</p><p>Чекист пер., д. 7, к. 2, г. Северск, Томская обл., 636013</p><p>Московский тракт, д. 2, г. Томск, 634050</p></bio><bio xml:lang="en"><p>Ravil M. Takhauov, Dr. Sci. (Med.), Prof., Honored Doctor of the Russian Federation, Director; Professor, Department of Health Care Management and Public Health</p><p>Bldg 2, 7 Chekist Lane, Seversk, Tomsk Region, 636013</p><p>2 Moskovsky Tract, Tomsk, 634050</p></bio><email xlink:type="simple">niirm2007@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН «Северский биофизический научный центр» ФМБА России; ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Seversk Biophysical Research Center; Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН «Северский биофизический научный центр» ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Seversk Biophysical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ «Сибирский федеральный научно-клинический центр» ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian Federal Scientific Clinical Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2022</year></pub-date><volume>30</volume><issue>12</issue><fpage>66</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Калинкин Д.Е., Тахауов А.Р., Тахауова Л.Р., Самойлова Ю.А., Мильто И.В., Тахауов Р.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Калинкин Д.Е., Тахауов А.Р., Тахауова Л.Р., Самойлова Ю.А., Мильто И.В., Тахауов Р.М.</copyright-holder><copyright-holder xml:lang="en">Kalinkin D.E., Takhauov A.R., Takhauova L.R., Samoilova Y.A., Milto I.V., Takhauov R.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zniso.fcgie.ru/jour/article/view/1171">https://zniso.fcgie.ru/jour/article/view/1171</self-uri><abstract><sec><title>Введение</title><p>Введение. Уран, являющийся сырьевой основой атомной отрасли, способен вызывать неблагоприятные медико-биологические последствия у работников, контактирующих в процессе профессиональной деятельности с его соединения- ми. Для исследования данного эффекта и детального изучения медико-биологических последствий воздействия соединений урана на организм персонала объектов использования атомной энергии необходимо сформировать когорту лиц, занятых в работах с соединениями урана.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: сформировать когорту и создать базу данных персонала Сибирского химического комбината, задействованного в работе с соединениями урана в период 1953–2000 гг.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Источником информации служил региональный медико-дозиметрический регистр Северского биофизического научного центра, содержащий информацию относительно всех действующих и бывших работников Сибирского химического комбината (около 65 000 человек) с момента основания предприятия по настоящее время.</p></sec><sec><title>Результаты</title><p>Результаты. Сформирована и описана когорта работников Сибирского химического комбината, задействованных в работе с соединениями урана в период 1953–2000 гг. Численность когорты составляет 1 484 человека (898 мужчин и 586 женщин). Медико-биологическая информация и дозиметрические сведения о работниках, включенных в когорту, внесены в созданную базу данных персонала Сибирского химического комбината, задействованного в работе с соединениями урана в период 1953–2000 гг.</p></sec><sec><title>Заключение</title><p>Заключение. Сформированная когорта и база данных позволят проводить эпидемиологические исследования по оценке заболеваемости и смертности персонала вследствие злокачественных новообразований, а также делать научно обоснованные выводы относительно роли соединений урана в возникновении злокачественных новообразований и смертности от них. Когорта работников Сибирского химического комбината, задействованных в работе с соединениями урана, соответствует по размеру и полноте представленной сопутствующей персональной и дозиметрической информации условиям, необходимым для проведения современных эпидемиологических исследований.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: Uranium, the basic raw material of the nuclear industry, poses health risks to people occupationally exposed to its compounds. Studies of adverse effects of radiation exposure in workers of nuclear facilities necessitate a cohort of employees handling uranium compounds.</p></sec><sec><title>Objective</title><p>Objective: To form a historic cohort and create a database of the personnel of the Siberian Chemical Plant exposed to uranium compounds at workplaces in 1953–2000.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: The source of information was the Regional Health and Dosimetry Register of the Seversk Biophysical Research Center, containing data on all current and former employees of the Siberian Chemical Plant (ca. 65,000 people) from the date of establishment of the company to the present.</p></sec><sec><title>Results</title><p>Results: We have created and described a cohort of 1,484 workers (898 men and 586 women) exposed to uranium compounds at the Siberian Chemical Plant in 1953–2000. Health and dosimetry information of the cohort members was entered in a specially developed database of the personnel of the Siberian Chemical Plant engaged in works with uranium compounds during that time period.</p></sec><sec><title>Conclusion</title><p>Conclusion: Both the retrospective cohort and the detailed database allow epidemiological studies of cancer incidence and mortality in the industry workers and evidence-based conclusions about the contribution of occupational exposure to uranium compounds. The cohort of employees of the Siberian Chemical Plant meets all the requirements of up-to-date epidemiological studies in terms of its size and completeness of health and exposure data.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>соединения урана</kwd><kwd>персонал радиационно опасного производства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>uranium compounds</kwd><kwd>personnel</kwd><kwd>radiation exposure</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках государственного задания № 388-00162-22-00 от 01.03.2022.</funding-statement><funding-statement xml:lang="en">The study was carried out within State Assignment No. 388-00162-22-00 dated March 1, 2022.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lane RSD, Frost SE, Howe GR, Zablotska LB. 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